PMID- 31882983
OWN - NLM
STAT- MEDLINE
DCOM- 20201207
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Dec 27
TI  - Characteristics of factors for decreased lung function in elderly patients with 
      type 2 diabetes.
PG  - 20206
LID - 10.1038/s41598-019-56759-3 [doi]
LID - 20206
AB  - Chronic obstructive pulmonary disease (COPD) often accompanies type 2 diabetes 
      mellitus (T2DM). However, background factors affecting these diseases in the 
      elderly remain unclear. Eligible patients with T2DM were divided into two age 
      groups-non-elderly (<65 years) and elderly (>/=65 years); COPD, ratio of forced 
      expiratory volume in one second to forced expiratory volume (FEV1/FVC ratio), and 
      percent predicted forced expiratory volume in one second (FEV1% predicted) were 
      examined, and factors related to reduced respiratory function according to age 
      group were evaluated. In total, 371 patients with T2DM were analysed. COPD was 
      found in 9 patients (5.3%) in the non-elderly group and 45 (22.5%) in the elderly 
      group. In the elderly, male sex, low body mass index (BMI), insulin therapy, and 
      high C-peptide immunoreactivity levels were factors related to COPD. In the 
      non-elderly, age, female sex, high BMI were factors related to decreased FEV1% 
      predicted. Female sex was factor related to decreased FEV1% predicted in both age 
      groups. Low BMI was a factor related to reduced respiratory function in elderly 
      patients and high BMI was a factor related to reduced respiratory function in 
      non-elderly patients. Thus, BMI needs to be managed according to the age and 
      general condition of T2DM patients.
FAU - Ishii, Masaki
AU  - Ishii M
AD  - The Department of Geriatric Medicine, The University of Tokyo, Tokyo, Japan. 
      ishii-tky@umin.ac.jp.
FAU - Yamaguchi, Yasuhiro
AU  - Yamaguchi Y
AD  - The Department of Geriatric Medicine, The University of Tokyo, Tokyo, Japan.
AD  - Division of Department of Respiratory Medicine, Jichi Medical University Saitama 
      Medical Center, Saitama, Japan.
FAU - Hamaya, Hironobu
AU  - Hamaya H
AD  - The Department of Geriatric Medicine, The University of Tokyo, Tokyo, Japan.
FAU - Ogawa, Sumito
AU  - Ogawa S
AD  - The Department of Geriatric Medicine, The University of Tokyo, Tokyo, Japan.
FAU - Imura, Mitsuo
AU  - Imura M
AD  - Okamoto Internal Medicine Clinic, Shizuoka, Japan.
FAU - Akishita, Masahiro
AU  - Akishita M
AD  - The Department of Geriatric Medicine, The University of Tokyo, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191227
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
EIN - Sci Rep. 2020 Feb 13;10(1):2817. PMID: 32054987
MH  - Aged
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Female
MH  - Humans
MH  - Pulmonary Disease, Chronic Obstructive/physiopathology
MH  - *Respiratory Function Tests
PMC - PMC6934766
COIS- The authors declare no competing interests.
EDAT- 2019/12/29 06:00
MHDA- 2020/12/15 06:00
PMCR- 2019/12/27
CRDT- 2019/12/29 06:00
PHST- 2019/09/18 00:00 [received]
PHST- 2019/12/16 00:00 [accepted]
PHST- 2019/12/29 06:00 [entrez]
PHST- 2019/12/29 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/12/27 00:00 [pmc-release]
AID - 10.1038/s41598-019-56759-3 [pii]
AID - 56759 [pii]
AID - 10.1038/s41598-019-56759-3 [doi]
PST - epublish
SO  - Sci Rep. 2019 Dec 27;9(1):20206. doi: 10.1038/s41598-019-56759-3.