PMID- 31883227
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211021
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 15
IP  - 1
DP  - 2021 Feb
TI  - N400 event-related brain potential as an index of real-world and neurocognitive 
      function in patients at clinical high risk for schizophrenia.
PG  - 68-75
LID - 10.1111/eip.12911 [doi]
AB  - AIM: The N400 event-related potential is a neurophysiological index of cognitive 
      processing of real-world knowledge. In healthy populations, N400 amplitude is 
      smaller in response to stimuli that are more related to preceding context. This 
      'N400 semantic priming effect' is thought to reflect activation of contextually 
      related information in semantic memory (SM). N400 semantic priming deficits have 
      been found in schizophrenia, and in patients at clinical high risk (CHR) for this 
      disorder. Because this abnormality in processing relationships between meaningful 
      stimuli could affect ability to navigate everyday situations, we hypothesized it 
      would be associated with real-world functional impairment in CHR patients. 
      Second, we hypothesized it would correlate with global neurocognitive impairment 
      in this group. METHODS: We measured N400 semantic priming in 35 CHR patients who 
      viewed prime words each followed by a related or unrelated target word, at 
      stimulus-onset asynchrony (SOA) of 300 or 750 ms. We measured 
      academic/occupational and social function with the global function (GF): Role and 
      Social scales, and cognitive function with the MATRICS Consensus Cognitive 
      Battery (MCCB). RESULTS: Decreased N400 semantic priming at the 300-ms SOA 
      correlated with lower GF:Role scores. Decreased N400 semantic priming at the 
      750-ms SOA correlated with lower MCCB composite scores. CONCLUSIONS: Deficits in 
      activating contextually related concepts in SM over short time intervals may 
      contribute to functional impairment in CHR patients. Furthermore, N400 priming 
      deficits over longer intervals may be a biomarker of global cognitive dysfunction 
      in this population. Longitudinal studies are needed to determine whether these 
      deficits are associated with schizophrenia risk within this population.
CI  - (c) 2019 John Wiley & Sons Australia, Ltd.
FAU - Lepock, Jennifer R
AU  - Lepock JR
AUID- ORCID: 0000-0002-0337-0299
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Ahmed, Sarah
AU  - Ahmed S
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
FAU - Gerritsen, Cory J
AU  - Gerritsen CJ
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Graduate Department of Psychological Clinical Science, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Maheandiran, Margaret
AU  - Maheandiran M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Bagby, R Michael
AU  - Bagby RM
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
AD  - Graduate Department of Psychological Clinical Science, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Korostil, Michele
AU  - Korostil M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
FAU - Kiang, Michael
AU  - Kiang M
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191227
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Brain
MH  - Electroencephalography
MH  - Evoked Potentials
MH  - Female
MH  - Humans
MH  - Male
MH  - Reaction Time
MH  - *Schizophrenia/complications
OTO - NOTNLM
OT  - clinical high risk
OT  - cognition
OT  - electroencephalography
OT  - event-related potentials
OT  - functional outcome
OT  - psychosis
EDAT- 2019/12/29 06:00
MHDA- 2023/02/25 06:00
CRDT- 2019/12/29 06:00
PHST- 2019/08/26 00:00 [received]
PHST- 2019/11/27 00:00 [revised]
PHST- 2019/12/14 00:00 [accepted]
PHST- 2019/12/29 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2019/12/29 06:00 [entrez]
AID - 10.1111/eip.12911 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2021 Feb;15(1):68-75. doi: 10.1111/eip.12911. Epub 2019 
      Dec 27.