PMID- 31884521
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1869-5760 (Print)
IS  - 1869-5760 (Electronic)
IS  - 1869-5760 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Dec 28
TI  - Topographic correlation between multifocal electroretinography, microperimetry, 
      and spectral-domain optical coherence tomography of the macula in patients with 
      birdshot chorioretinopathy.
PG  - 24
LID - 10.1186/s12348-019-0188-5 [doi]
LID - 24
AB  - PURPOSE: To correlate the findings of retinal function with multifocal 
      electroretinogram (mfERG), microperimetry (MP), and structural assessments with 
      spectral-domain optical coherence tomography (SD-OCT) in topographically 
      corresponding areas of the macula of patients with birdshot chorioretinopathy 
      (BSCR). METHODS: Patients diagnosed with BSCR by clinical and imaging findings 
      were included in the study. The mfERG was performed using 61 hexagon stimulus 
      patterns grouped into 5 rings (Diagnosys Inc., USA). Individual responses [N1-P1 
      amplitudes in nanovolt (NV)/degree(2) and P1 implicit time in milliseconds 
      (msec)] for each hexagon in the central 3 rings (R1, 0 degrees -2.3 degrees ; R2,2.3 degrees -7.7 degrees ; and 
      R3, 7.7 degrees -12 degrees ) were obtained (19 hexagons). MP examination consisted of Polar 
      3-12 degrees  test with 28 points in 3 concentric rings with diameters of approximately 
      2.3 degrees , 6.6 degrees , and 11.1 degrees  from the foveal center. SD-OCT was performed using macular 
      scans of 20 degrees  x 20 degrees . The retinal sensitivity values on MP and thickness values of 
      retinal layers were correlated with the responses on the mfERG for each 
      topographically correlated hexagon. RESULTS: Sixteen eyes of eight patients were 
      included in the study (mean age, 59.87 +/- 10.01 years; range, 41-73 years). The 
      amplitudes and the implicit times on mfERG and retinal sensitivities on MP were 
      decreased for each of the 19 hexagons. Considering retinotopically matched 
      points, there was correlation between the retinal sensitivities and mfERG 
      implicit times and response amplitudes in all three rings. The thickness of the 
      retinal pigment epithelium showed modest correlation with the mfERG parameters (rho 
      = 0.29; p = 0.04). The structural changes on SD-OCT, such as IS-OS disruption, 
      were associated with changes in the mfERG trace arrays. CONCLUSIONS: The 
      structural and functional assessments in retinae of eyes with BSCR suggest that 
      each imaging tool may be capturing unique aspects of retinal dysfunction. 
      Multimodal imaging may allow detailed analyses of retinal damage at various 
      corresponding loci. These findings are important when considering the use of 
      these techniques in BSCR.
FAU - Afridi, Rubbia
AU  - Afridi R
AD  - Ocular Imaging Research and Reading Center, Menlo Park, CA, USA.
AD  - Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
FAU - Agarwal, Aniruddha
AU  - Agarwal A
AD  - Advanced Eye Center, Department of Ophthalmology, Post Graduate Institute of 
      Medical Education and Research (PGIMER), Chandigarh, India.
FAU - Nguyen, Nam V
AU  - Nguyen NV
AD  - Ocular Imaging Research and Reading Center, Menlo Park, CA, USA.
FAU - Hassan, Muhammad
AU  - Hassan M
AD  - Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
FAU - Sadiq, Mohammad Ali
AU  - Sadiq MA
AD  - Ocular Imaging Research and Reading Center, Menlo Park, CA, USA.
FAU - Nguyen, Quan Dong
AU  - Nguyen QD
AD  - Ocular Imaging Research and Reading Center, Menlo Park, CA, USA.
AD  - Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
FAU - Sepah, Yasir J
AU  - Sepah YJ
AUID- ORCID: 0000-0002-0104-6284
AD  - Ocular Imaging Research and Reading Center, Menlo Park, CA, USA. 
      yjs@stanford.edu.
AD  - Byers Eye Institute, Stanford University, Palo Alto, CA, USA. yjs@stanford.edu.
LA  - eng
PT  - Journal Article
DEP - 20191228
PL  - Germany
TA  - J Ophthalmic Inflamm Infect
JT  - Journal of ophthalmic inflammation and infection
JID - 101553216
PMC - PMC6935379
OTO - NOTNLM
OT  - Birdshot chorioretinopathy
OT  - Microperimetry
OT  - Multifocal electroretinogram
OT  - Multimodal imaging
OT  - Optical coherence tomography
COIS- The authors declare that they have no competing interests.
EDAT- 2019/12/31 06:00
MHDA- 2019/12/31 06:01
PMCR- 2019/12/28
CRDT- 2019/12/30 06:00
PHST- 2019/07/27 00:00 [received]
PHST- 2019/11/14 00:00 [accepted]
PHST- 2019/12/30 06:00 [entrez]
PHST- 2019/12/31 06:00 [pubmed]
PHST- 2019/12/31 06:01 [medline]
PHST- 2019/12/28 00:00 [pmc-release]
AID - 10.1186/s12348-019-0188-5 [pii]
AID - 188 [pii]
AID - 10.1186/s12348-019-0188-5 [doi]
PST - epublish
SO  - J Ophthalmic Inflamm Infect. 2019 Dec 28;9(1):24. doi: 10.1186/s12348-019-0188-5.