PMID- 31884719
OWN - NLM
STAT- MEDLINE
DCOM- 20200818
LR  - 20221207
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 74
IP  - 4
DP  - 2020 Apr
TI  - Dietary acid load, blood pressure, fasting blood sugar and biomarkers of insulin 
      resistance among adults: Findings from an updated systematic review and 
      meta-analysis.
PG  - e13471
LID - 10.1111/ijcp.13471 [doi]
AB  - OBJECTIVES: There is no clear summarised report of the association between 
      dietary acid load components including potential renal acid load (PRAL) and 
      net-endogenous acid production (NEAP) with cardiometabolic risk factors. In the 
      current meta-analysis, we aimed to systematically review and summarise the 
      eligible observational studies evaluating the association between PRAL and NEAP 
      with blood pressure and hypertension and markers of glucose haemostasis among 
      adults. DESIGN AND SETTING: In a systematic search from PubMed, SCOPUS, Web of 
      Sciences and Cochrane electronic databases up to May 2019, relevant studies were 
      included in the literature review. Observational studies evaluating the 
      association between PRAL and NEAP with the systolic blood pressure (SBP), 
      diastolic blood pressure (DBP), fasting blood glucose, insulin, homeostatic model 
      assessment of insulin resistance (HOMA-IR), haemoglobin A(1) C (HbA(1) C), HOMA-beta 
      and quantitative insulin check index (QUICKI) and also prevalence or odds of 
      hypertension, hyperglycaemia and diabetes were included. RESULTS: Total number of 
      studies included in the 14 separate meta-analyses were as follows: Mean (SD) of 
      SBP (PRAL, n = 12; NEAP, n = 6), mean (SD) of DBP (PRAL, n = 8; NEAP, n = 3), 
      mean (SD) of FBS (PRAL, n = 12; NEAP, n = 5), mean (SD) of HbA(1) C (PRAL, n = 6; 
      NEAP, n = 4), mean (SD) of HOMA-IR (PRAL, n = 7), mean (SD) of insulin (PRAL, 
      n = 7; NEAP, n = 2); OR of type 2 diabetes mellitus (T(2) DM) (PRAL, n = 8; NEAP; 
      n = 6), HTN prevalence (PRAL, n = 9; NEAP, n = 9), T(2) DM prevalence (PRAL, 
      n = 7; NEAP, n = 6). According to our results, being in the highest PRAL 
      categories was associated with higher SBP (WMD = 0.98; CI: 0.51, 1.45; P < .001), 
      DBP (WMD = 0.61; CI: 0.089, 1.135; P = .022), insulin (WMD = -0.235, CI: 0.070, 
      0.400; P = .005), higher odds of diabetes (OR = 1.19; CI: 1.092, 1.311; 
      P < .001), higher prevalence of T(2) DM (13% and 11% in highest vs lowest 
      category). While, being in the highest category of NEAP was only associated with 
      higher odds of diabetes (OR = 1.22; CI: 1.14, 1.31, P < .001). In subgroup 
      analysis for finding the possible source of heterogeneity, the continent, dietary 
      assessment tool, sample size and gender were the potent sources of heterogeneity. 
      No association between PRAL and NEAP with HbA(1) C, HOMA-IR was reported. 
      CONCLUSIONS: In the current meta-analysis, we found potent negative effects of 
      high dietary acid load particularly higher PRAL scores cardiometabolic risk 
      factors. Therefore, lower acidogenic food ingredients in the diets are suggested 
      for the prevention of cardiovascular risk factors and diabetes.
CI  - (c) 2019 John Wiley & Sons Ltd.
FAU - Dehghan, Parvin
AU  - Dehghan P
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Abbasalizad Farhangi, Mahdieh
AU  - Abbasalizad Farhangi M
AUID- ORCID: 0000-0002-7036-6900
AD  - Research Center for Evidence Based Medicine, Health Management and Safety 
      Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
LA  - eng
GR  - IR.TBZMED.VCR.REC.1398.140/Tabriz University of Medical Sciences/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200107
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Acids/*administration & dosage/*metabolism
MH  - Blood Glucose
MH  - *Blood Pressure
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Diet
MH  - Fasting
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypertension/*epidemiology
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Observational Studies as Topic
MH  - Prevalence
MH  - Risk Factors
OTO - NOTNLM
OT  - NEAP
OT  - PRAL
OT  - blood pressure
OT  - diabetes
OT  - dietary acid load
OT  - hypertension
OT  - markers of glucose homoeostasis
EDAT- 2019/12/31 06:00
MHDA- 2020/08/19 06:00
CRDT- 2019/12/30 06:00
PHST- 2019/10/31 00:00 [received]
PHST- 2019/12/07 00:00 [revised]
PHST- 2019/12/24 00:00 [accepted]
PHST- 2019/12/31 06:00 [pubmed]
PHST- 2020/08/19 06:00 [medline]
PHST- 2019/12/30 06:00 [entrez]
AID - 10.1111/ijcp.13471 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2020 Apr;74(4):e13471. doi: 10.1111/ijcp.13471. Epub 2020 Jan 
      7.