PMID- 31885721
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231027
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 19
IP  - 1
DP  - 2020 Jan
TI  - Comparing cryoablation and microwave ablation for the treatment of patients with 
      stage IIIB/IV non-small cell lung cancer.
PG  - 1031-1041
LID - 10.3892/ol.2019.11149 [doi]
AB  - The aim of the present study was to compare the safety and efficacy of 
      cryoablation (CA) and microwave ablation (MWA) as treatments for non-small cell 
      lung cancer (NSCLC). Patients with stage IIIB or IV NSCLC treated with CA (n=45) 
      or MWA (n=56) were enrolled in the present study. The primary endpoint was 
      progression-free survival (PFS); the secondary endpoints included overall 
      survival (OS) time and adverse events (AEs). The median PFS times between the two 
      groups were not significantly different (P=0.36): CA, 10 months [95% confidence 
      interval (CI), 7.5-12.4] vs. MWA, 11 months (95% CI, 9.5-12.4). The OS times 
      between the two groups were also not significantly different (P=0.07): CA, 27.5 
      months (95% CI, 22.8-31.2 months) vs. MWA, 18 months (95% CI, 12.5-23.5). For 
      larger tumors (>3 cm), patients treated with MWA had significantly longer median 
      PFS (P=0.04; MWA, 10.5 months vs. CA, 7.0 months) and OS times (P=0.04; MWA, 24.5 
      months vs. CA, 14.5 months) compared patients treated with CA. However, for 
      smaller tumors (</=3 cm), median PFS (P=0.79; MWA, 11.0 months vs. CA, 13.0 months) 
      and OS times (P=0.39; MWA, 30.0 months vs. CA, 26.5 months) between the two 
      groups did not differ significantly. The incidence rates of AEs were similar in 
      the two groups (P>0.05). The number of applicators, tumor size and length of the 
      lung traversed by applicators were associated with a higher risk of pneumothorax 
      and intra-pulmonary hemorrhage in the two groups. Treatment with CA resulted in 
      significantly less intraprocedural pain compared with treatment with MWA 
      (P=0.001). Overall, the present study demonstrated that CA and MWA were 
      comparably safe and effective procedures for the treatment of small tumors. 
      However, treatment with MWA was superior compared with CA for the treatment of 
      large tumors.
CI  - Copyright (c) 2020, Spandidos Publications.
FAU - Das, Sushant Kumar
AU  - Das SK
AD  - Department of Interventional Radiology, Affiliated Hospital of North Sichuan 
      Medical College, Nanchong, Sichuan 637000, P.R. China.
FAU - Huang, Ya-Yong
AU  - Huang YY
AD  - Department of Radiology, Xuzhou City Center Hospital, Xuzhou, Jiangsu 221009, 
      P.R. China.
FAU - Li, Bing
AU  - Li B
AD  - Department of Interventional Radiology, Affiliated Hospital of North Sichuan 
      Medical College, Nanchong, Sichuan 637000, P.R. China.
FAU - Yu, Xiao Xuan
AU  - Yu XX
AD  - Department of Interventional Radiology, Affiliated Hospital of North Sichuan 
      Medical College, Nanchong, Sichuan 637000, P.R. China.
FAU - Xiao, Ru Hui
AU  - Xiao RH
AD  - Department of Interventional Radiology, Affiliated Hospital of North Sichuan 
      Medical College, Nanchong, Sichuan 637000, P.R. China.
FAU - Yang, Han Feng
AU  - Yang HF
AD  - Department of Interventional Radiology, Affiliated Hospital of North Sichuan 
      Medical College, Nanchong, Sichuan 637000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20191125
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6924207
OTO - NOTNLM
OT  - cryoablation
OT  - lung cancer
OT  - microwave ablation
OT  - overall survival
OT  - progression-free survival
EDAT- 2019/12/31 06:00
MHDA- 2019/12/31 06:01
PMCR- 2019/11/25
CRDT- 2019/12/31 06:00
PHST- 2019/05/13 00:00 [received]
PHST- 2019/10/25 00:00 [accepted]
PHST- 2019/12/31 06:00 [entrez]
PHST- 2019/12/31 06:00 [pubmed]
PHST- 2019/12/31 06:01 [medline]
PHST- 2019/11/25 00:00 [pmc-release]
AID - OL-0-0-11149 [pii]
AID - 10.3892/ol.2019.11149 [doi]
PST - ppublish
SO  - Oncol Lett. 2020 Jan;19(1):1031-1041. doi: 10.3892/ol.2019.11149. Epub 2019 Nov 
      25.