PMID- 31886073 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 11 IP - 11 DP - 2019 Nov 12 TI - Subtle Cryptococcal Immune Reconstitution Inflammatory Syndrome. PG - e6138 LID - 10.7759/cureus.6138 [doi] LID - e6138 AB - Patients with HIV and opportunistic infections (OIs), such as tuberculosis and cryptococcosis, have been recognised to have immune reconstitution inflammatory syndrome (IRIS) following initiation of highly active antiretroviral therapy (HAART). The initiation of HAART boosts CD4 T cells, which result in exacerbations of OIs. We have identified deterioration of neural lesion in imaging after the initiation of HAART in a patient with HIV/cryptococcal infection, although patient's clinical conditions have not deteriorated. It is evident that IRIS is in subtlety. This has been possible because of prompt treatment with antifungal drugs for the cryptococcal infection, followed by early initiation of HAART. CI - Copyright (c) 2019, Singh et al. FAU - Singh, Ranjan K AU - Singh RK AD - Internal Medicine, Anti-Retroviral Therapy Centre, District Hospital, Khagaria, IND. LA - eng PT - Case Reports DEP - 20191112 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC6907719 OTO - NOTNLM OT - cryptococcal infection OT - hiv OT - iris COIS- The authors have declared that no competing interests exist. EDAT- 2019/12/31 06:00 MHDA- 2019/12/31 06:01 PMCR- 2019/11/12 CRDT- 2019/12/31 06:00 PHST- 2019/12/31 06:00 [entrez] PHST- 2019/12/31 06:00 [pubmed] PHST- 2019/12/31 06:01 [medline] PHST- 2019/11/12 00:00 [pmc-release] AID - 10.7759/cureus.6138 [doi] PST - epublish SO - Cureus. 2019 Nov 12;11(11):e6138. doi: 10.7759/cureus.6138.