PMID- 31886290
OWN - NLM
STAT- MEDLINE
DCOM- 20200609
LR  - 20200609
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2019
DP  - 2019
TI  - Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes 
      Mellitus Development in Ukrainian Population.
PG  - 9302636
LID - 10.1155/2019/9302636 [doi]
LID - 9302636
AB  - Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary 
      predisposition, so both environmental and genetic factors contribute to its 
      development. Recent studies have demonstrated that the skeleton realizes systemic 
      regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, 
      the association analysis between HindIII single nucleotide polymorphism of OCN 
      gene (BGLAP) promoter region and T2DM development in Ukrainian population was 
      carried out. 153 individuals diagnosed with T2DM and 311 control individuals were 
      enrolled in the study. The genotyping was performed using polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) method. The lack of 
      association between BGLAP HindIII single nucleotide polymorphism (SNP) and T2DM 
      development among Ukrainians was found. Further studies with extended groups of 
      comparison are needed to confirm the obtained results.
CI  - Copyright (c) 2019 Yaroslav D. Chumachenko et al.
FAU - Chumachenko, Yaroslav D
AU  - Chumachenko YD
AUID- ORCID: 0000-0002-4803-5435
AD  - Scientific Laboratory of Molecular Genetic Studies, Medical Institute of the Sumy 
      State University, 40007, Ukraine.
FAU - Harbuzova, Viktoriia Yu
AU  - Harbuzova VY
AD  - Scientific Laboratory of Molecular Genetic Studies, Medical Institute of the Sumy 
      State University, 40007, Ukraine.
FAU - Ataman, Alexander V
AU  - Ataman AV
AD  - Department of Physiology and Pathophysiology with Medical Biology Course, Medical 
      Institute of the Sumy State University, 40018, Ukraine.
LA  - eng
PT  - Journal Article
DEP - 20191127
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (BGLAP protein, human)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/*genetics
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Risk Factors
MH  - Ukraine/epidemiology
PMC - PMC6900942
COIS- There is no conflict of interests.
EDAT- 2019/12/31 06:00
MHDA- 2020/06/10 06:00
PMCR- 2019/11/27
CRDT- 2019/12/31 06:00
PHST- 2019/09/01 00:00 [received]
PHST- 2019/10/16 00:00 [revised]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2019/12/31 06:00 [entrez]
PHST- 2019/12/31 06:00 [pubmed]
PHST- 2020/06/10 06:00 [medline]
PHST- 2019/11/27 00:00 [pmc-release]
AID - 10.1155/2019/9302636 [doi]
PST - epublish
SO  - J Diabetes Res. 2019 Nov 27;2019:9302636. doi: 10.1155/2019/9302636. eCollection 
      2019.