PMID- 31887593
OWN - NLM
STAT- MEDLINE
DCOM- 20200612
LR  - 20200612
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 259
DP  - 2020 Apr
TI  - Is dietary macronutrient intake associated with serum concentrations of 
      organochlorine pesticides in humans?
PG  - 113819
LID - S0269-7491(19)33739-X [pii]
LID - 10.1016/j.envpol.2019.113819 [doi]
AB  - In the general population, chronic exposure to low-dose persistent organic 
      pollutants (POPs), particularly organochlorine pesticides (OCPs), has been 
      recently linked to many chronic diseases. Widespread contamination of the food 
      chain and human adipose tissue has made avoiding exposure to these chemicals 
      impossible; thus, alternative strategies for decreasing the chemical burden must 
      be investigated. Recently, macronutrient intake was found to significantly modify 
      the toxicokinetics of POPs in animal experimental studies. Thus, we evaluated 
      whether macronutrient intake was related to serum concentrations of OCPs in 
      healthy adults without cardio-metabolic diseases. Subjects included 1,764 adults, 
      aged 20 years or above, who participated in the National Health and Nutrition 
      Examination Survey 1999-2004. Macronutrient intake was assessed based on a 24-h 
      dietary recall interview. Six individual OCPs commonly detected among the general 
      population were evaluated as markers of OCPs and other coexisting lipophilic 
      chemicals stored in adipose tissue and released into circulation. High fat intake 
      was associated with lower concentrations of OCPs, while high carbohydrate intake 
      showed the opposite result. When three types of fats were individually evaluated, 
      both saturated fatty acids and monounsaturated fatty acids, but not 
      polyunsaturated fatty acids, were inversely associated with serum concentrations 
      of OCPs. Adjustment for possible confounders did not change the results. When 
      stratified by age, gender, body mass index, and physical activity, these 
      associations were similar in most subgroups. Thus, similar to the findings 
      observed in animal experimental studies, a moderate-fat diet with low 
      carbohydrate intake was related to low serum concentrations of OCPs in humans. 
      Although these findings need to be replicated, changing dietary macronutrient 
      intake can be investigated as a practical strategy for dealing with unavoidable 
      lipophilic chemical mixtures such as OCPs in modern society.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Lee, Yu-Mi
AU  - Lee YM
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea. Electronic address: yumilee@knu.ac.kr.
FAU - Heo, Somi
AU  - Heo S
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea. Electronic address: boong1207@naver.com.
FAU - Kim, Se-A
AU  - Kim SA
AD  - Department of Biomedical Science, Graduate School, Kyungpook National University, 
      Daegu, Republic of Korea; BK21 Plus KNU Biomedical Convergence Program, 
      Department of Biomedical Science, Kyungpook National University, Daegu, Republic 
      of Korea. Electronic address: rose5522@naver.com.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea; BK21 Plus KNU Biomedical Convergence 
      Program, Department of Biomedical Science, Kyungpook National University, Daegu, 
      Republic of Korea. Electronic address: lee_dh@knu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20191216
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Adult
MH  - *Diet
MH  - Environmental Exposure/*statistics & numerical data
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - *Nutrients
MH  - Nutrition Surveys
MH  - Pesticides/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Adipose tissue
OT  - Low carbohydrate high fat diet
OT  - Macronutrient
OT  - Organochlorine pesticide
OT  - Persistent organic pollutant
EDAT- 2019/12/31 06:00
MHDA- 2020/06/13 06:00
CRDT- 2019/12/31 06:00
PHST- 2019/07/17 00:00 [received]
PHST- 2019/12/03 00:00 [revised]
PHST- 2019/12/13 00:00 [accepted]
PHST- 2019/12/31 06:00 [pubmed]
PHST- 2020/06/13 06:00 [medline]
PHST- 2019/12/31 06:00 [entrez]
AID - S0269-7491(19)33739-X [pii]
AID - 10.1016/j.envpol.2019.113819 [doi]
PST - ppublish
SO  - Environ Pollut. 2020 Apr;259:113819. doi: 10.1016/j.envpol.2019.113819. Epub 2019 
      Dec 16.