PMID- 31889465
OWN - NLM
STAT- MEDLINE
DCOM- 20200515
LR  - 20200515
IS  - 1744-5132 (Electronic)
IS  - 0927-3972 (Linking)
VI  - 28
IP  - 1
DP  - 2020 Mar
TI  - Nystagmus with pendular low amplitude, high frequency components (PLAHF) in 
      association with retinal disease.
PG  - 3-6
LID - 10.1080/09273972.2019.1707237 [doi]
AB  - Purposes: To establish a relation between pendular low amplitude high frequency 
      (PLAHF) components and congenital retinal disorders.Methods: Patients who showed 
      PLAHF components in their eye-movement recording between January 2016 to January 
      2019 were included. Best corrected visual acuity (BCVA), refraction, strabismus 
      assessment, fundus photograph, spectral domain-optical coherence tomography 
      (SD-OCT), full-field electroretinography (f-ERG), clinical ophthalmological 
      examination, and gene tests were used to determine their clinical conditions, 
      especially their retina conditions in all patients.Results: Among 136 patients 
      there were 76 males and 60 females with mean age of 11.4.5 +/- 4.5 years. Pure 
      PLAHF waveforms were found in 38 patients (28%), the amplitude of the PLAHF was 
      2 degrees +/-1.6 degrees  and frequency was 5-10 Hz. Superimposed PLAHF waveforms were found in 98 
      patients (72%). BCVA was worse than Log MAR1.0 in 94 patients (69%), between 
      LogMar 0.5-1.0 (20/63-20/200) in 30 cases (22%); higher than LogMar 0.5 (20/63) 
      in 12 cases (9%). Fifty-eight patients were diagnosed with exotropia and six 
      patients with esotropia. Abnormal Fundus were found in 71 cases (52%), fovea 
      hypoplasia was identified with OCT in 95 cases (70%) and retinal thinning in 92 
      cases (68%). Abnormal on-off VEP were found in 116 cases (85%). The f-ERG 
      responses were reduced in all patients. In 46 patients, gene mutations were found 
      to related to retinal disease, including 3 congenital stationary night blindness 
      (CSNB), 14 achromatopsia (ACHM), 5 Aland Island eye disease (AIED), 7 Alstrom 
      syndrome (AS), 11 Leber congenital amaurosis (LCA), 6 cone-rod dystrophy 
      (CRD).Conclusions: Patients presenting with PLAHF usually had retinal disorders.
FAU - Wang, Ping
AU  - Wang P
AD  - Children's Eye Disease and Ocular Motility Institute of Purui Jina, Shandong 
      Purui Liangkang Eye Hospital, Jinan, Shandong Province, P. R. China.
FAU - Ya, Pan
AU  - Ya P
AD  - Children's Eye Disease and Ocular Motility Institute of Purui Jina, Shandong 
      Purui Liangkang Eye Hospital, Jinan, Shandong Province, P. R. China.
FAU - Li, Deshun
AU  - Li D
AD  - Children's Eye Disease and Ocular Motility Institute of Purui Jina, Shandong 
      Purui Liangkang Eye Hospital, Jinan, Shandong Province, P. R. China.
FAU - Lv, Shuangjun
AU  - Lv S
AD  - Children's Eye Disease and Ocular Motility Institute of Purui Jina, Shandong 
      Purui Liangkang Eye Hospital, Jinan, Shandong Province, P. R. China.
FAU - Yang, Dongsheng
AU  - Yang D
AD  - Children's Eye Disease and Ocular Motility Institute of Purui Jina, Shandong 
      Purui Liangkang Eye Hospital, Jinan, Shandong Province, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20191231
PL  - England
TA  - Strabismus
JT  - Strabismus
JID - 9310896
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Electronystagmography
MH  - Electroretinography
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Nystagmus, Pathologic/*diagnosis/physiopathology
MH  - Retinal Dystrophies/*diagnosis/physiopathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Nystagmus
OT  - nystagmus waveform
OT  - retina disorders
EDAT- 2020/01/01 06:00
MHDA- 2020/05/16 06:00
CRDT- 2020/01/01 06:00
PHST- 2020/01/01 06:00 [pubmed]
PHST- 2020/05/16 06:00 [medline]
PHST- 2020/01/01 06:00 [entrez]
AID - 10.1080/09273972.2019.1707237 [doi]
PST - ppublish
SO  - Strabismus. 2020 Mar;28(1):3-6. doi: 10.1080/09273972.2019.1707237. Epub 2019 Dec 
      31.