PMID- 31889566
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 2173-5751 (Electronic)
IS  - 2173-5751 (Linking)
VI  - 56
IP  - 9
DP  - 2020 Sep
TI  - Prevalence of Alpha-1 Antitrypsin Deficiency in COPD Patients in Argentina. The 
      DAAT.AR Study.
PG  - 571-577
LID - S0300-2896(19)30578-2 [pii]
LID - 10.1016/j.arbres.2019.11.010 [doi]
AB  - INTRODUCTION: Alpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, 
      despite the recommendation to determine AAT in patients with chronic obstructive 
      pulmonary disease (COPD). OBJECTIVE: To estimate the prevalence of AATD in COPD 
      patients adjusted according to the population of the COPD prevalence study in 
      Argentina (EPOC.AR). MATERIAL AND METHODS: This was a multicenter prospective 
      cross-sectional study of a population aged>/=30 years of age diagnosed with COPD, 
      involving AAT quantification in dry blood spot and subsequent genotyping in 
      subjects with<1.5mg/dL AAT in dry blood spot (<80mg/dL in serum). AAT was defined 
      as the detection of variants ZZ or SZ on genotyping. The EPOC.AR study population 
      was used to calculate local adjusted prevalence. RESULTS: We included 3,254 
      patients (544 with AAT<80mg/dL) with a spirometric diagnosis of COPD. The 
      prevalence of AATD in the total study population was 1.29% (95% CI 0.93-1.74), of 
      which 0.92% (95% CI 0.62-1.31) were Pi*ZZ and 0.37% (95% CI 0.19-0.64) Pi*SZ. The 
      adjusted prevalence of AATD in COPD patients>/=40 years of age was 0.83% (95% CI 
      0.23-2.08). We found that AATD was negatively associated with age (OR 0.94; 95% 
      CI 0.90-0.98; P=.006), smoking habit (OR 0.98; 95% CI 0.96-0.99; P=.009), and 
      FEV(1)% (OR 0.95; 95% CI 0.91-0.99; P=.015). CONCLUSIONS: The prevalence of AATD 
      in the adult population with COPD in Argentina is estimated to be 0.83%, which 
      could represent 17,000 cases in our country.
CI  - Copyright (c) 2019. Publicado por Elsevier Espana, S.L.U.
FAU - Menga, Guillermo
AU  - Menga G
AD  - Hospital Municipal de Rehabilitacion Respiratoria Maria Ferrer, Buenos Aires, 
      Argentina.
FAU - Fernandez Acquier, Mariano
AU  - Fernandez Acquier M
AD  - Hospital Zonal Especializado de Agudos y Cronicos Dr. Antonio Cetrangolo, Vicente 
      Lopez, Argentina. Electronic address: acquier@hotmail.com.
FAU - Echazarreta, Andres L
AU  - Echazarreta AL
AD  - Hospital Interzonal Especializado de Agudos y Cronicos San Juan de Dios, La 
      Plata, Argentina.
FAU - Sorroche, Patricia B
AU  - Sorroche PB
AD  - Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
FAU - Lorenzon, Maria V
AU  - Lorenzon MV
AD  - Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
FAU - Fernandez, Martin E
AU  - Fernandez ME
AD  - Hospital Municipal de Rehabilitacion Respiratoria Maria Ferrer, Buenos Aires, 
      Argentina.
FAU - Saez, Maria S
AU  - Saez MS
AD  - Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
CN  - grupo de estudio DAAT.AR
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
TT  - Prevalencia de deficit de alfa-1 antitripsina en pacientes con EPOC en Argentina. 
      Estudio DAAT.AR.
DEP - 20191227
PL  - Spain
TA  - Arch Bronconeumol (Engl Ed)
JT  - Archivos de bronconeumologia
JID - 101777538
SB  - IM
MH  - Adult
MH  - Argentina/epidemiology
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Prevalence
MH  - Prospective Studies
MH  - *Pulmonary Disease, Chronic Obstructive/epidemiology
MH  - *alpha 1-Antitrypsin Deficiency/complications
OTO - NOTNLM
OT  - Alpha-1 antitrypsin deficiency
OT  - Argentina
OT  - Chronic obstructive pulmonary disease
OT  - DAAT.AR
OT  - Deficit de alfa-1 antitripsina
OT  - EPOC.AR
OT  - Enfermedad pulmonar obstructiva cronica
OT  - Prevalence
OT  - Prevalencia
EDAT- 2020/01/01 06:00
MHDA- 2021/06/25 06:00
CRDT- 2020/01/01 06:00
PHST- 2019/06/01 00:00 [received]
PHST- 2019/10/25 00:00 [revised]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2020/01/01 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2020/01/01 06:00 [entrez]
AID - S0300-2896(19)30578-2 [pii]
AID - 10.1016/j.arbres.2019.11.010 [doi]
PST - ppublish
SO  - Arch Bronconeumol (Engl Ed). 2020 Sep;56(9):571-577. doi: 
      10.1016/j.arbres.2019.11.010. Epub 2019 Dec 27.