PMID- 31889833 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231027 IS - 1319-562X (Print) IS - 2213-7106 (Electronic) IS - 2213-7106 (Linking) VI - 27 IP - 1 DP - 2020 Jan TI - Interrelationship between oxidative stress, DNA damage and cancer risk in diabetes (Type 2) in Riyadh, KSA. PG - 177-183 LID - 10.1016/j.sjbs.2019.06.015 [doi] AB - Type 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiology underlying T2DM. Besides, oxidative stress can result in DNA damage leading to high cancer risk. Current study aimed to evaluate status of oxidative damage, damage to DNA and cancer biomarkers in regard to increased glucose in T2DM patients and to correlate the glycemic state with cancer. A total of 150 subjects consisting of control (50) and T2DM patients (1 0 0) were enrolled. Additionally, three tertiles were created among the two groups based on levels of HbA1c (Tertile I = 5.37 +/- 0.34, n = 50; Tertile II = 6.74 +/- 0.20, n = 50; Tertile III = 9.21 +/- 1.47, n = 50). Oxidative stress parameters including malondialedehyde (MDA) and antioxidant enzymes were measured. Damage to DNA was analyzed by measuring the levels of DNA damage adduct-8 hydroxy deoxy Guanosine (8-OHdG). To detect cancer resulting from oxidative stress, cancer biomarkers CEA, AFP, CA125, CA-15, CA19-9, prolactin were measured in these subjects. All measurements were analysed by SPSS software. Levels of MDA and antioxidant enzymes altered significantly in T2DM group at p < 0.001 and p < 0.05 level of significance. Significant DNA damage accompanied with elevated levels of CEA, CA19-9 and decreased CA125, AFP and prolactin were noted in T2DM group. CA 19-9 and CEA levels increased at p < 0.05, whereas levels of prolactin decreased significantly (p < 0.001) in T2DM group compared to control. Additionally the mean values of DNA damage adduct 8-OHdG differ significantly at P < 0.01 between the two groups. However, no significant correlation in oxidative stress parameter, antioxidant enzymes, DNA damage and neither with the highest tertile of HbA1c (>7.5%) was noted. Based on the results obtained in the present study, we conclude that there is considerable change in oxidative stress and DNA damage in T2DM patients. Hence, assumption that the oxidative stress could cause cancer in T2DM as a result of hyperglycemic state was not speculated in this study. CI - (c) 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University. FAU - Abudawood, Manal AU - Abudawood M AD - Clinical Laboratory Sciences, King Saud University, Riyadh, Saudi Arabia. FAU - Tabassum, Hajera AU - Tabassum H AD - Clinical Laboratory Sciences, King Saud University, Riyadh, Saudi Arabia. FAU - Almaarik, Basmah AU - Almaarik B AD - Clinical Laboratory Sciences, King Saud University, Riyadh, Saudi Arabia. FAU - Aljohi, Ali AU - Aljohi A AD - Central Military Laboratory & Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20190624 PL - Saudi Arabia TA - Saudi J Biol Sci JT - Saudi journal of biological sciences JID - 101543796 PMC - PMC6933234 OTO - NOTNLM OT - Cancer OT - Damage DNA OT - Diabetes mellitus OT - Oxidative damage COIS- The authors declared that there is no conflict of interest. EDAT- 2020/01/01 06:00 MHDA- 2020/01/01 06:01 PMCR- 2019/06/24 CRDT- 2020/01/01 06:00 PHST- 2019/04/16 00:00 [received] PHST- 2019/06/10 00:00 [revised] PHST- 2019/06/23 00:00 [accepted] PHST- 2020/01/01 06:00 [entrez] PHST- 2020/01/01 06:00 [pubmed] PHST- 2020/01/01 06:01 [medline] PHST- 2019/06/24 00:00 [pmc-release] AID - S1319-562X(19)30115-9 [pii] AID - 10.1016/j.sjbs.2019.06.015 [doi] PST - ppublish SO - Saudi J Biol Sci. 2020 Jan;27(1):177-183. doi: 10.1016/j.sjbs.2019.06.015. Epub 2019 Jun 24.