PMID- 31890045
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 11
DP  - 2019
TI  - The effect of genistein on lipid levels and LDLR, LXRalpha and ABCG1 expression in 
      postmenopausal women with hyperlipidemia.
PG  - 111
LID - 10.1186/s13098-019-0507-x [doi]
LID - 111
AB  - BACKGROUND: This study investigates the effect of genistein (Gen) on the lipid 
      profiles and expression of low-density lipoprotein receptor (LDLR), liver X 
      receptor alpha (LXRalpha) and ATP-binding cassette transporter G1 (ABCG1) in the plasma 
      macrophages of postmenopausal women with hyperlipidemia in China. METHODS: This 
      study considered 187 cases, where 160 postmenopausal women had hyperlipidemia. 
      The subjects were divided into placebo group (PG) and experimental group (EG). EG 
      received 60 mg/day of Gen, PG received placebo for 6 months. Body weight, height, 
      waist circumference, body mass index and glucose levels were determined according 
      to standard operating procedures. The triglyceride (TG), total cholesterol (TC), 
      low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol 
      (HDL-C), apolipoprotein-A1 (Apo-A1) and apolipoprotein-B (Apo-B) levels were 
      detected in the plasma macrophages using ELISA. The protein and mRNA expression 
      levels of LDLR, LXRalpha and ABCG1 were detected by western blot and real-time PCR 
      techniques, respectively. RESULTS: Compared to the baseline, Gen effectively 
      lowered TG, TC and LDL-C levels, whereas HDL-C levels as well as the protein and 
      mRNA expression levels of LDLR, LXRalpha and ABCG1 (p < 0.05) were increased. There 
      was a significant difference in the expression of LDLR protein between the two 
      groups (p < 0.05). The mRNA expression levels of LDLR, LXRalpha and ABCG1 were 
      significantly increased in the EG compared to the PG. CONCLUSION: Gen effectively 
      modulated the plasma lipid indices. The cholesterol-lowering effects of Gen may 
      be attributed to its regulation on some of the key genes involved in cholesterol 
      homeostasis.
CI  - (c) The Author(s) 2019.
FAU - Zhang, Tao
AU  - Zhang T
AD  - 1College of Medical Laboratory Science and Technology, Harbin Medical 
      University-Daqing, Daqing, 163319 Heilongjiang Province China. ISNI: 0000 0001 
      2204 9268. GRID: grid.410736.7
FAU - Chi, Xiao-Xing
AU  - Chi XX
AD  - 2College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, 
      163319 Heilongjiang Province China. ISNI: 0000 0004 1808 3449. GRID: 
      grid.412064.5
AD  - Agri-Food Processing and Engineering Technology Research Center of Heilongjiang 
      Province, Daqing, 163319 Heilongjiang Province China.
LA  - eng
PT  - Journal Article
DEP - 20191219
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC6924062
OTO - NOTNLM
OT  - Cholesterol related genes
OT  - Genistein
OT  - Hyperlipidemia
OT  - Postmenopausal women
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2020/01/01 06:00
MHDA- 2020/01/01 06:01
PMCR- 2019/12/19
CRDT- 2020/01/01 06:00
PHST- 2019/11/07 00:00 [received]
PHST- 2019/12/11 00:00 [accepted]
PHST- 2020/01/01 06:00 [entrez]
PHST- 2020/01/01 06:00 [pubmed]
PHST- 2020/01/01 06:01 [medline]
PHST- 2019/12/19 00:00 [pmc-release]
AID - 507 [pii]
AID - 10.1186/s13098-019-0507-x [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2019 Dec 19;11:111. doi: 10.1186/s13098-019-0507-x. 
      eCollection 2019.