PMID- 31890456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2186-3644 (Print)
IS  - 2186-361X (Electronic)
IS  - 2186-3644 (Linking)
VI  - 8
IP  - 4
DP  - 2019 Nov
TI  - A case of recurrent progressive multifocal leukoencephalopathy after human stem 
      cell transplant, with detection of John Cunningham virus and human herpesvirus 6 
      on cerebrospinal fluid, treated with Mirtazapine, Olanzapine and Foscarnet.
PG  - 275-278
LID - 10.5582/irdr.2019.01107 [doi]
AB  - We reported the case of a John Cunningham virus (JCV) and human herpesvirus 6 
      (HHV-6) mediated progressive multifocal leukoencephalopathy (PML) after human 
      stem cell transplant, reactivated 6 months later in absence of immunosuppressive 
      therapy, successfully treated with anti-5HT2A receptors agents and antiviral 
      therapy. Few cases of JCV and HHV-6 coinfection associated PML are described in 
      literature and the role of HHV-6 in the pathogenesis and prognosis of PML is not 
      completely clear. Our case suggests that, in a possible PML, the research of 
      HHV-6 and JCV should be always performed on cerebrospinal fluid (CSF) and on 
      blood samples and in case of detection of HHV-6 DNA a chromosomally integrated 
      human herpesvirus 6(ciHHV-6) should be excluded. Furthermore we recommend to 
      start an appropriate therapy with antiviral and anti-5HT2A receptors agents in 
      case of possible PML due to JCV and HHV-6 coinfection.
CI  - 2019, International Research and Cooperation Association for Bio & Socio - 
      Sciences Advancement.
FAU - Pasca, Matteo
AU  - Pasca M
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
FAU - Picchioni, Antonella
AU  - Picchioni A
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
FAU - Mazzeo, Salvatore
AU  - Mazzeo S
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
FAU - Terenzi, Federica
AU  - Terenzi F
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
FAU - Prestipino, Elio
AU  - Prestipino E
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
FAU - Fratangelo, Roberto
AU  - Fratangelo R
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
FAU - Repice, Anna Maria
AU  - Repice AM
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
AD  - Neurological Division II Careggi University Hospital, Florence, Italy.
FAU - Carlucci, Giovanna
AU  - Carlucci G
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
AD  - Neurological Division II Careggi University Hospital, Florence, Italy.
FAU - Massacesi, Luca
AU  - Massacesi L
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
AD  - Neurological Division II Careggi University Hospital, Florence, Italy.
FAU - Barilaro, Alessandro
AU  - Barilaro A
AD  - Department of Neurological and Psychiatric sciences (NEUROFARBA), University of 
      Florence, Florence, Italy.
AD  - Neurological Division II Careggi University Hospital, Florence, Italy.
LA  - eng
PT  - Case Reports
PL  - Japan
TA  - Intractable Rare Dis Res
JT  - Intractable & rare diseases research
JID - 101586847
PMC - PMC6929596
OTO - NOTNLM
OT  - CNS infection
OT  - Neurovirology
OT  - human herpesvirus 6
EDAT- 2020/01/01 06:00
MHDA- 2020/01/01 06:01
PMCR- 2019/11/01
CRDT- 2020/01/01 06:00
PHST- 2020/01/01 06:00 [entrez]
PHST- 2020/01/01 06:00 [pubmed]
PHST- 2020/01/01 06:01 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - 10.5582/irdr.2019.01107 [doi]
PST - ppublish
SO  - Intractable Rare Dis Res. 2019 Nov;8(4):275-278. doi: 10.5582/irdr.2019.01107.