PMID- 31890669
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 18
IP  - 2
DP  - 2019 Dec
TI  - Investigation of oxidative stress markers and antioxidant enzymes activity in 
      newly diagnosed type 2 diabetes patients and healthy subjects, association with 
      IL-6 level.
PG  - 437-443
LID - 10.1007/s40200-019-00437-8 [doi]
AB  - OBJECTIVE: Oxidative stress and inflammation play an important role in the 
      pathogenesis of diabetes and its complication. In this study, we aimed to 
      evaluate and compare oxidative stress markers and antioxidant enzymes activity, 
      as well as Interleukin 6 (IL-6) level in newly diagnosed type 2 diabetes mellitus 
      (T2DM) patients and healthy subjects. MATERIAL AND METHODS: 30 newly diagnosed 
      type 2 diabetes patients and 30 healthy subjects (age and sex matched) were 
      recruited in this study. After anthropometric parameters measurement, blood 
      sample were collected from all participant. Serum and plasma were isolated. 
      Biochemical parameters were evaluated in serum. Plasma was used to measure 
      malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity 
      (TAC) levels, as well as superoxide dismutase (SOD) and glutathione peroxidase 
      (GPx) activity. Also, IL-6 level was investigated in plasma using ELISA method. 
      RESULTS: MDA and TOS levels were significantly higher in T2DM patients than the 
      control group (p < 0.05). However, TAC and SOD were significantly lower in T2DM 
      as compared with healthy subjects (p < 0.05). Also, IL-6 level was higher in T2DM 
      in comparison to healthy subjects (p = 0.004). Furthermore, there was a 
      significant positive correlation between IL-6 with MDA (p = 0.031, r = 0.482) and 
      TOS (p < 0.001, r = 0.744). In addition, a negative correlation was observed 
      between IL-6 and SOD activity (p = 0.002, r = -0.660). CONCLUSION: Reducing 
      oxidative stress and inflammation could be effective in improvement of T2DM.
CI  - (c) Springer Nature Switzerland AG 2019.
FAU - Arab Sadeghabadi, Zahra
AU  - Arab Sadeghabadi Z
AD  - 1Department of Clinical Biochemistry, School of Medicine, Hamadan University of 
      Medical Sciences, Hamadan, Iran. GRID: grid.411950.8. ISNI: 0000 0004 0611 9280
FAU - Abbasalipourkabir, Roghayeh
AU  - Abbasalipourkabir R
AD  - 1Department of Clinical Biochemistry, School of Medicine, Hamadan University of 
      Medical Sciences, Hamadan, Iran. GRID: grid.411950.8. ISNI: 0000 0004 0611 9280
FAU - Mohseni, Roohollah
AU  - Mohseni R
AD  - 1Department of Clinical Biochemistry, School of Medicine, Hamadan University of 
      Medical Sciences, Hamadan, Iran. GRID: grid.411950.8. ISNI: 0000 0004 0611 9280
FAU - Ziamajidi, Nasrin
AU  - Ziamajidi N
AUID- ORCID: 0000-0002-7473-9823
AD  - 1Department of Clinical Biochemistry, School of Medicine, Hamadan University of 
      Medical Sciences, Hamadan, Iran. GRID: grid.411950.8. ISNI: 0000 0004 0611 9280
AD  - 2Molecular Medicine Research Center, Hamadan University of Medical Sciences, 
      Hamadan, Iran. GRID: grid.411950.8. ISNI: 0000 0004 0611 9280
LA  - eng
PT  - Journal Article
DEP - 20190909
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC6915251
OTO - NOTNLM
OT  - Interleukin 6 (IL-6)
OT  - Malondialdehyde (MDA)
OT  - Superoxide dismutase (SOD) and glutathione peroxidase (GPx)
OT  - Total antioxidant capacity (TAC)
OT  - Total oxidant status (TOS)
OT  - Type 2 diabetes mellitus (T2DM)
COIS- Conflict of interestThe authors declare no conflict of interest.
EDAT- 2020/01/01 06:00
MHDA- 2020/01/01 06:01
PMCR- 2020/09/09
CRDT- 2020/01/01 06:00
PHST- 2019/04/30 00:00 [received]
PHST- 2019/08/28 00:00 [accepted]
PHST- 2020/01/01 06:00 [entrez]
PHST- 2020/01/01 06:00 [pubmed]
PHST- 2020/01/01 06:01 [medline]
PHST- 2020/09/09 00:00 [pmc-release]
AID - 437 [pii]
AID - 10.1007/s40200-019-00437-8 [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2019 Sep 9;18(2):437-443. doi: 
      10.1007/s40200-019-00437-8. eCollection 2019 Dec.