PMID- 31890678 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220412 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 18 IP - 2 DP - 2019 Dec TI - Wingless-type MMTV integration site family member 5a: a novel biomarker regulated in type 2 diabetes mellitus and diabetic kidney disease. PG - 525-532 LID - 10.1007/s40200-019-00461-8 [doi] AB - OBJECTIVES: Type 2 diabetes mellitus (T2DM) is sustained by insulin resistance (IR) and reduced beta-cell mass, which is largely due to insulin secretory dysfunction. Wnt5a protein is essential to islet formation and beta-cell migration in the development of pancreas in vertebrates. Levels of the Wnt5a protein antagonist plasma secreted frizzled-related protein 5 (Sfrp5) were elevated in patients with T2DM. However, the association between Wnt5a, T2DM patients and diabetic kidney disease (DKD) is unknown. We aim to investigate the circulating Wnt5a levels in in different clinical stages of T2DM and evaluate its correlation of duration of diabetes mellitus chronic complication. METHODS: A total of 329 participants (187 males, 142 females; age range 40 to 80 years) were enrolled in this study. Serum Wnt5a levels were measured by an enzyme-linked immunosorbent assay (ELISA). The demographic and clinical parameters evaluated in subjects with new onset T2DM, onset T2DM after treatment and DKD at different clinical phases. RESULTS: Wnt5a was significantly down-regulated in newly diagnosed T2DM patients and gradually increased after 3 months of treatment. Interesting, serum wnt5a was gradually increased in patients with long-term diabetes and kidney disease compared to patients with T2DM and onset DKD. CONCLUSIONS: We speculated that the Wnt5a protein might regulate islet function and be involved in the onset of diabetes as a protective factor. It may be one of the inflammatory factors adversely involved in the progression of diabetic nephropathy. CI - (c) The Author(s) 2019. FAU - Xu, Wei AU - Xu W AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 AD - 2Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, SE1 1UL UK. GRID: grid.13097.3c. ISNI: 0000 0001 2322 6764 FAU - Geng, Houfa AU - Geng H AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Liu, Xuekui AU - Liu X AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Wang, Xiuli AU - Wang X AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Li, Rui AU - Li R AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Lv, Qian AU - Lv Q AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Liu, Yin AU - Liu Y AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Wang, Jie AU - Wang J AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Yang, Manqing AU - Yang M AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 FAU - Jones, Peter M AU - Jones PM AD - 2Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, SE1 1UL UK. GRID: grid.13097.3c. ISNI: 0000 0001 2322 6764 FAU - Liang, Jun AU - Liang J AD - 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, 221009 Jiangsu China. GRID: grid.263826.b. ISNI: 0000 0004 1761 0489 LA - eng PT - Journal Article DEP - 20191122 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC6915239 OTO - NOTNLM OT - Diabetic kidney disease OT - Type 2 diabetes mellitus OT - Wingless-type MMTV integration site family member 5a EDAT- 2020/01/01 06:00 MHDA- 2020/01/01 06:01 PMCR- 2019/11/22 CRDT- 2020/01/01 06:00 PHST- 2019/01/13 00:00 [received] PHST- 2019/10/29 00:00 [accepted] PHST- 2020/01/01 06:00 [entrez] PHST- 2020/01/01 06:00 [pubmed] PHST- 2020/01/01 06:01 [medline] PHST- 2019/11/22 00:00 [pmc-release] AID - 461 [pii] AID - 10.1007/s40200-019-00461-8 [doi] PST - epublish SO - J Diabetes Metab Disord. 2019 Nov 22;18(2):525-532. doi: 10.1007/s40200-019-00461-8. eCollection 2019 Dec.