PMID- 31891116
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 2520-1026 (Electronic)
IS  - 2520-1026 (Linking)
VI  - 3
DP  - 2019
TI  - Serum levels of reactive oxygen metabolites at 12 weeks during tocilizumab 
      therapy are predictive of 52 weeks-disease activity score-remission in patients 
      with rheumatoid arthritis.
PG  - 48
LID - 10.1186/s41927-019-0096-1 [doi]
LID - 48
AB  - BACKGROUND: To verify whether serum levels of reactive oxygen metabolites (ROM) 
      are predictive of future clinical remission in patients with rheumatoid arthritis 
      (RA) receiving tocilizumab (TCZ) therapy. METHODS: A total of 46 patients with RA 
      receiving TCZ therapy were enrolled in this study. Patients were divided into 
      remission and non-remission groups based on disease activity score 28 
      (DAS28)-erythrocyte sedimentation rate (ESR) or clinical disease activity index 
      (CDAI) at 52 weeks. Associations between serum levels of ROM, C-reactive protein 
      (CRP), and matrix metalloproteinase-3 (MMP-3) at 4 and 12 weeks and the remission 
      by DAS28-ESR and CDAI at 52 weeks were investigated. RESULTS: There were no 
      significant differences in CRP and MMP-3 between DAS- or CDAI-remission and 
      non-remission groups at 12 weeks. However, ROM in DAS-remission group were 
      significantly lower than those in the non-remission group. For ROM, the area 
      under the curve of the receiver operating characteristic curve was 0.735 and the 
      cut-off value that distinguished DAS-remission group from non-remission group was 
      305.5 U. Carr (sensitivity: 70.0%, specificity: 72.2%). A multivariate logistic 
      regression analysis revealed that ROM at 12 weeks was associated with 
      DAS-remission at 52 weeks (odds ratio: 6.067, 95% confidence interval: 
      1.305-28.203). CONCLUSION: Serum levels of ROM at 12 weeks during TCZ therapy may 
      be predictive of DAS-remission at 52 weeks in patients with RA.
CI  - (c) The Author(s) 2019.
FAU - Nakajima, Arata
AU  - Nakajima A
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
AD  - 2Department of Rheumatology, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
AD  - 3Department of Rehabilitation, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Terayama, Keiichiro
AU  - Terayama K
AD  - 3Department of Rehabilitation, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Sonobe, Masato
AU  - Sonobe M
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Aoki, Yasuchika
AU  - Aoki Y
AD  - 4Department of General Medical Sciences, Graduate School of Medicine, Chiba 
      University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677 Japan. ISNI: 0000 0004 0370 
      1101. GRID: grid.136304.3
AD  - Department of Orthopaedic Surgery, Eastern Chiba Medical Center, 3-6-2 
      Okayamadai, Togane, Chiba, 283-8686 Japan.
FAU - Takahashi, Hiroshi
AU  - Takahashi H
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Akatsu, Yorikazu
AU  - Akatsu Y
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Saito, Junya
AU  - Saito J
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Taniguchi, Shinji
AU  - Taniguchi S
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Yamada, Manabu
AU  - Yamada M
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
FAU - Kubota, Ayako
AU  - Kubota A
AD  - 6Department of Orthopaedics, Toho University Omori Medical Center, 6-11-1 
      Omori-nishi, Ota-ku, Tokyo, 143-8541 Japan. ISNI: 0000 0004 1771 2506. GRID: 
      grid.452874.8
FAU - Nakagawa, Koichi
AU  - Nakagawa K
AD  - 1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 
      Shimoshizu, Sakura, Chiba, 285-8741 Japan. ISNI: 0000 0000 9290 9879. GRID: 
      grid.265050.4
LA  - eng
PT  - Journal Article
DEP - 20191216
PL  - England
TA  - BMC Rheumatol
JT  - BMC rheumatology
JID - 101738571
PMC - PMC6912997
OTO - NOTNLM
OT  - Biomarker
OT  - Reactive oxygen metabolites
OT  - Remission
OT  - Rheumatoid arthritis
OT  - Tocilizumab
COIS- Competing interestsThe authors declare that they have no competing interest.
EDAT- 2020/01/01 06:00
MHDA- 2020/01/01 06:01
PMCR- 2019/12/16
CRDT- 2020/01/01 06:00
PHST- 2019/06/13 00:00 [received]
PHST- 2019/10/10 00:00 [accepted]
PHST- 2020/01/01 06:00 [entrez]
PHST- 2020/01/01 06:00 [pubmed]
PHST- 2020/01/01 06:01 [medline]
PHST- 2019/12/16 00:00 [pmc-release]
AID - 96 [pii]
AID - 10.1186/s41927-019-0096-1 [doi]
PST - epublish
SO  - BMC Rheumatol. 2019 Dec 16;3:48. doi: 10.1186/s41927-019-0096-1. eCollection 
      2019.