PMID- 31891992
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 209
DP  - 2020 Mar 1
TI  - Application of dispersive liquid-liquid microextraction based on solidification 
      of floating organic drop for the determination of extractables from 
      pharmaceutical packaging materials.
PG  - 120540
LID - S0039-9140(19)31173-7 [pii]
LID - 10.1016/j.talanta.2019.120540 [doi]
AB  - A new method was established for the determination of the extractables from 
      pharmaceutical packaging materials using dispersive liquid-liquid microextraction 
      based on solidification of floating organic drop (DLLME-SFO) coupled with 
      ultra-high-performance liquid chromatography quadrupole time-of-flight mass 
      spectrometry (UHPLC-QTOF MS). Packaging samples were filled with three kinds of 
      buffer solutions: acid buffer (pH = 3), alkaline buffer (pH = 9) and 0.9% NaCl 
      solution to extract as many extractables as possible, and then the extractables 
      in buffer solutions were enriched by DLLME-SFO technique. Parameters affecting 
      the efficiency of the extraction procedure were evaluated and optimized, 
      including the type and volume of dispersant, extractant volume, pH and 
      vortex-mixing time. After optimization, the values obtained for limits of 
      detection and quantification for three kinds of common antioxidants were 0.3 and 
      1.0 mug/L respectively, and good linearity (R(2) > 0.99) was observed in their 
      respective concentration ranges. The recoveries ranged from 80.61% to 117.87% at 
      three spiked levels with the relative standard deviations (RSDs) between 0.92% 
      and 9.29% (n = 6) in all three buffer solutions. The developed method was 
      successfully applied to the analysis of extractables from pharmaceutical 
      packaging materials. The results indicated that the proposed procedure is a 
      novel, sensitive, fast and repeatable method and has a great significance for 
      evaluation of safety of pharmaceutical packaging materials.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Sun, Xuechun
AU  - Sun X
AD  - College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, 
      China.
FAU - Xing, Xuebin
AU  - Xing X
AD  - College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, 
      China.
FAU - Du, Zhenxia
AU  - Du Z
AD  - College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, 
      China; College of Chemistry, Beijing Key Laboratory of Environmentally Harmful 
      Chemical Analysis, Beijing University of Chemical Technology, Beijing, 100029, 
      China. Electronic address: duzx@mail.buct.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191109
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Antioxidants)
RN  - 0 (Solvents)
RN  - 0 (Triazoles)
RN  - 1P9D0Z171K (Butylated Hydroxytoluene)
RN  - 3896-11-5 (tinuvin)
SB  - IM
MH  - Antioxidants/*analysis
MH  - Butylated Hydroxytoluene/analogs & derivatives/*analysis
MH  - Chromatography, High Pressure Liquid/methods
MH  - *Drug Packaging/methods
MH  - Liquid Phase Microextraction/*methods
MH  - Mass Spectrometry/methods
MH  - Solvents
MH  - Triazoles/*analysis
OTO - NOTNLM
OT  - DLLME-SFO
OT  - Pharmaceutical packaging materials
OT  - Safety analysis
OT  - UHPLC-QTOF MS
EDAT- 2020/01/02 06:00
MHDA- 2020/06/09 06:00
CRDT- 2020/01/02 06:00
PHST- 2019/06/19 00:00 [received]
PHST- 2019/10/26 00:00 [revised]
PHST- 2019/11/03 00:00 [accepted]
PHST- 2020/01/02 06:00 [entrez]
PHST- 2020/01/02 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
AID - S0039-9140(19)31173-7 [pii]
AID - 10.1016/j.talanta.2019.120540 [doi]
PST - ppublish
SO  - Talanta. 2020 Mar 1;209:120540. doi: 10.1016/j.talanta.2019.120540. Epub 2019 Nov 
      9.