PMID- 31892048
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20200106
LR  - 20200106
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 209
DP  - 2020 Mar 1
TI  - Development of an automatic sequential injection analysis-lab on valve system 
      exploiting molecularly imprinted polymers coupled with high performance liquid 
      chromatography for the determination of estrogens in wastewater samples.
PG  - 120564
LID - S0039-9140(19)31197-X [pii]
LID - 10.1016/j.talanta.2019.120564 [doi]
AB  - In recent years, the discharge of estrogens into the environmental water bodies 
      through the effluents of sewage treatment plants is an issue of increasing 
      concern, since they can act as endocrine-disrupting compounds. For this reason, 
      there is a need of developing selective, sensitive and environmentally friendly 
      methodologies for their determination. In this work, we present an automatic 
      procedure for the clean-up, preconcentration and quantification of the estrogens 
      most used in contraceptives (estrone, E1; 17beta-estradiol, E2; estriol, E3; and 
      17alpha-ethynylestradiol, EE2), which are also catalogued as Contaminants of Emergent 
      Concern by the Environmental Protection Agency of the United States (US EPA). A 
      sequential injection analysis-lab on valve system (SIA-LOV) using a molecularly 
      imprinted polymer (MIP) as a sorbent has been developed to perform the selective 
      microsolid phase extraction (muSPE) of the analytes in a fully automated way. 
      Several parameters affecting the extraction have been optimized following 
      multivariate approaches. Besides, the preconcentration system has been coupled to 
      an HPLC for the estrogens quantification. Low limits of detection (LODs) and 
      limits of quantification (LOQs) have been achieved; hence the studied estrogens 
      can be quantified in a wide range of concentrations, i.e. 9.2-100 mug L(-1) of E3, 
      8.7-100 mug L(-1) of E2, 6.5-100 mug L(-1) of EE2 and 7.9-100 mug L(-1) of E1. 
      Besides, satisfactory precision has been obtained, with relative standard 
      deviations (RSDs) lower than 4.9% and 12.1% for intra and inter-day precision, 
      respectively. Finally, the method has been successfully applied to real 
      wastewater samples.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Gonzalez, Alba
AU  - Gonzalez A
AD  - Sciware Systems, S.L. Spin-off from the University of the Balearic Islands, C/ Pi 
      37, 07193, Illes Balears, Spain.
FAU - Cerda, Victor
AU  - Cerda V
AD  - Sciware Systems, S.L. Spin-off from the University of the Balearic Islands, C/ Pi 
      37, 07193, Illes Balears, Spain; Department of Chemistry, Faculty of Sciences, 
      University of the Balearic Islands, Carretera de Valldemossa Km 7.5, E-07122, 
      Palma de Mallorca, Illes Balears, Spain. Electronic address: victor.cerda@uib.es.
LA  - eng
PT  - Journal Article
DEP - 20191115
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
SB  - IM
OTO - NOTNLM
OT  - Automation
OT  - Estrogens
OT  - Lab-on-valve
OT  - Liquid chromatography
OT  - Microsolid phase extraction
EDAT- 2020/01/02 06:00
MHDA- 2020/01/02 06:01
CRDT- 2020/01/02 06:00
PHST- 2019/08/02 00:00 [received]
PHST- 2019/11/04 00:00 [revised]
PHST- 2019/11/12 00:00 [accepted]
PHST- 2020/01/02 06:00 [entrez]
PHST- 2020/01/02 06:00 [pubmed]
PHST- 2020/01/02 06:01 [medline]
AID - S0039-9140(19)31197-X [pii]
AID - 10.1016/j.talanta.2019.120564 [doi]
PST - ppublish
SO  - Talanta. 2020 Mar 1;209:120564. doi: 10.1016/j.talanta.2019.120564. Epub 2019 Nov 
      15.