PMID- 31892506
OWN - NLM
STAT- MEDLINE
DCOM- 20210507
LR  - 20210507
IS  - 1878-3562 (Electronic)
IS  - 1590-8658 (Linking)
VI  - 52
IP  - 4
DP  - 2020 Apr
TI  - Effects of anti-TNF-alpha therapy on hemoglobin levels and anemia in patients 
      with inflammatory bowel disease.
PG  - 400-407
LID - S1590-8658(19)30944-2 [pii]
LID - 10.1016/j.dld.2019.11.019 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is involved in inducing inflammatory 
      anemia. The potential effect of anti-TNF-alpha agents on anemia in inflammatory bowel 
      diseases (IBD) is still unknown. METHODS: Analytical data and disease 
      characteristics from 362 IBD patients [271 CD/91UC) treated with anti-TNF-alpha drugs 
      were retrospectively collected. Effects on disease activity, blood markers and 
      prevalence of anemia were assessed after 6 and 12 months of therapy. RESULTS: 
      29.3% patients presented anemia at baseline, and significantly reduced to 14.4% 
      and 7.8% after 6 and 12 months of therapy, respectively. Mean +/- SD Hb levels 
      increased significantly at month 6, and this increase was sustained at 12 months. 
      Serum markers of iron metabolism increased significantly compared to baseline, as 
      disease activity measured by C-reactive protein (CRP) was reduced. All these 
      effects were observed independently for CD and UC, and were independent of iron 
      supplementation during treatment. Anemia at baseline (OR 4.09; 95%CI 1.98-8.45) 
      and elevated CRP (OR 3.45; 95CI 1.29-9.22) were independently associated with 
      risk of persistent anemia, as well as iron replacement during therapy (OR 4.36; 
      95%CI 2.07-9.16). CONCLUSIONS: Controlling disease activity with anti-TNF- alpha 
      therapy significantly and independently associated with resolution of anemia in 
      IBD, with no relevant role for iron replacement therapy.
CI  - Copyright (c) 2019 Editrice Gastroenterologica Italiana S.r.l. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Lucendo, Alfredo J
AU  - Lucendo AJ
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain; 
      Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas 
      (CIBERehd), Spain; Instituto de Investigacion Sanitaria La Princesa, Madrid, 
      Spain. Electronic address: ajlucendo@hotmail.com.
FAU - Roncero, Oscar
AU  - Roncero O
AD  - Department of Gastroenterology, Hospital General La Mancha Centro, Alcazar de San 
      Juan, Spain.
FAU - Serrano-Duenas, Maria Teresa
AU  - Serrano-Duenas MT
AD  - Department of Gastroenterology/IBD Unit, Hospital General Universitario de Ciudad 
      Real, Spain.
FAU - Hervias, Daniel
AU  - Hervias D
AD  - Department of Gastroenterology, Hospital Virgen de Altagracia, Manzanares, Spain.
FAU - Alcazar, Luis Miguel
AU  - Alcazar LM
AD  - Department of Gastroenterology, Hospital Gutierrez Ortega, Valdepenas, Spain.
FAU - Miriam-Ruiz-Ponce
AU  - Miriam-Ruiz-Ponce
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain; 
      Instituto de Investigacion Sanitaria La Princesa, Madrid, Spain.
FAU - Verdejo, Cristina
AU  - Verdejo C
AD  - Department of Gastroenterology/IBD Unit, Hospital General Universitario de Ciudad 
      Real, Spain.
FAU - Laserna-Mendieta, Emilio
AU  - Laserna-Mendieta E
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain; 
      Instituto de Investigacion Sanitaria La Princesa, Madrid, Spain; Clinical 
      Laboratory, Hospital General de Villarrobledo, Villarrobledo, Spain.
FAU - Lorente, Rufo
AU  - Lorente R
AD  - Department of Gastroenterology/IBD Unit, Hospital General Universitario de Ciudad 
      Real, Spain.
FAU - Arias, Angel
AU  - Arias A
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas 
      (CIBERehd), Spain; Instituto de Investigacion Sanitaria La Princesa, Madrid, 
      Spain; Research Support Unit, Hospital General La Mancha Centro, Alcazar de San 
      Juan, Spain.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20191228
PL  - Netherlands
TA  - Dig Liver Dis
JT  - Digestive and liver disease : official journal of the Italian Society of 
      Gastroenterology and the Italian Association for the Study of the Liver
JID - 100958385
RN  - 0 (Biomarkers)
RN  - 0 (Hemoglobins)
RN  - 0 (Iron Compounds)
RN  - 0 (Tumor Necrosis Factor Inhibitors)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia/blood/drug therapy/*epidemiology/etiology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hemoglobins/drug effects/*metabolism
MH  - Humans
MH  - Inflammatory Bowel Diseases/blood/complications/*drug therapy
MH  - Iron Compounds/therapeutic use
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Spain/epidemiology
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor Inhibitors/*therapeutic use
MH  - Young Adult
OTO - NOTNLM
OT  - Anemia
OT  - Crohn's disease
OT  - Inflammatory bowel disease
OT  - Ulcerative colitis
EDAT- 2020/01/02 06:00
MHDA- 2021/05/08 06:00
CRDT- 2020/01/02 06:00
PHST- 2019/09/11 00:00 [received]
PHST- 2019/11/16 00:00 [revised]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2020/01/02 06:00 [pubmed]
PHST- 2021/05/08 06:00 [medline]
PHST- 2020/01/02 06:00 [entrez]
AID - S1590-8658(19)30944-2 [pii]
AID - 10.1016/j.dld.2019.11.019 [doi]
PST - ppublish
SO  - Dig Liver Dis. 2020 Apr;52(4):400-407. doi: 10.1016/j.dld.2019.11.019. Epub 2019 
      Dec 28.