PMID- 31892985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231027
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 11
IP  - 1
DP  - 2020
TI  - C-MYC, BCL2 and BCL6 Translocation in B-cell Non-Hodgkin Lymphoma Cases.
PG  - 190-198
LID - 10.7150/jca.36954 [doi]
AB  - C-MYC, BCL2 and BCL6 genes are the most commonly oncogenes involved in B-Cell 
      lymphomas. Translocations of these oncogenes are associated with an aggressive 
      clinical course. This study aims to elucidate the patterns of BCL6, BCL2 and 
      C-MYC gene aberrations among Malaysian B-cell Non-Hodgkin Lymphoma (NHL) using 
      fluorescence in situ hybridization (FISH). Eighty-one B-cell NHL tissue blocks 
      were retrieved between the year 2011 to 2015 and investigated using 
      immunohistochemistry and interphase FISH dual colour break-apart probes of BCL2, 
      BCL6, C-MYC and IgH. A significant difference was detected between the nodal and 
      extranodal sites in all the BCL2 (p=0.01), C-MYC (p=0.03) and IgH (p=0.006) cases 
      except for BCL6 (p=0.2). Our study showed that BCL6 had the highest gene 
      translocation while BCL2/BCL6 had the most mixed aberrations of gain copies and 
      translocation, however no mixed aberrations of gain copies and translocation was 
      found in C-MYC. None of the mixed gain copies and translocation was found in any 
      of the germinal centre B-cell (GCB) subtype of Diffuse Large B-cell Lymphoma, 
      however, five were found in BCL6 and IgH gene in the non-GCB subtype; while mixed 
      gain copies and translocation cases of BCL2 gene was found in the Follicular 
      Lymphoma cases only. The study found interesting findings of BCL2, C-MYC and IgH 
      gene aberrations between nodal and extranodal sites. This information might 
      benefit future study in predicting prognosis and determine effective therapeutic 
      strategies in the multi-ethnic populations of Malaysia as well as the Asian 
      population.
CI  - (c) The author(s).
FAU - Salam, Dayang Sharyati Datu Abdul
AU  - Salam DSDA
AD  - Faculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur, Malaysia.
FAU - Thit, Ei Ei
AU  - Thit EE
AD  - Advanced Molecular Pathology Laboratory, SingHealth Tissue Repository, Singapore.
FAU - Teoh, Siew Hoon
AU  - Teoh SH
AD  - Faculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur, Malaysia.
FAU - Tan, Soo Yong
AU  - Tan SY
AD  - National University Hospital, Singapore.
FAU - Peh, Suat Cheng
AU  - Peh SC
AD  - Sunway University Hospital, Selangor, Malaysia.
FAU - Cheah, Shiau-Chuen
AU  - Cheah SC
AD  - Faculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20200101
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC6930405
OTO - NOTNLM
OT  - BCL2
OT  - B-cell Non-Hodgkin Lymphoma
OT  - BCL6
OT  - C-MYC
OT  - FISH
OT  - gene abberation
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2020/01/02 06:00
MHDA- 2020/01/02 06:01
PMCR- 2020/01/01
CRDT- 2020/01/02 06:00
PHST- 2019/05/23 00:00 [received]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2020/01/02 06:00 [entrez]
PHST- 2020/01/02 06:00 [pubmed]
PHST- 2020/01/02 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - jcav11p0190 [pii]
AID - 10.7150/jca.36954 [doi]
PST - epublish
SO  - J Cancer. 2020 Jan 1;11(1):190-198. doi: 10.7150/jca.36954. eCollection 2020.