PMID- 31893569
OWN - NLM
STAT- MEDLINE
DCOM- 20210225
LR  - 20210225
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 12
IP  - 6
DP  - 2020 Jun
TI  - Increased urocortin 3 levels are associated with the risk of having type 2 
      diabetes mellitus.
PG  - 474-482
LID - 10.1111/1753-0407.13020 [doi]
AB  - BACKGROUND: Urocortin 3 (UCN3) is a peptide hormone playing a pivotal role in 
      glucose and lipid metabolisms. However, its clinical implications remain unclear. 
      Our aims were to investigate the altered levels of UCN3 in newly diagnosed type 2 
      diabetes mellitus (nT2DM) patients in comparison to subjects with normal glucose 
      tolerance (NGT) and to determine the presence of any possible link between UCN3 
      levels and metabolic parameters. METHODS: Eighty nT2DM and 80 age-, body mass 
      index (BMI)-, and gender-matched NGT subjects were enrolled into this 
      case-control study. The circulating UCN3 levels were measured using the 
      enzyme-linked immunoabsorbent assay (ELISA). Metabolic parameters of enrolled 
      subjects were also determined. A standard 75-g 2-hour oral glucose tolerance test 
      was used for diagnosis of type 2 diabetes mellitus (T2DM). RESULTS: UCN3 levels 
      were higher in subjects with nT2DM than in controls (115.64 +/- 39.26 vs 
      86.16 +/- 22.81 pg/mL, P < .001). UCN3 levels were increased in subjects with 
      metabolic syndrome compared to subjects without metabolic syndrome in both nT2DM 
      and NGT groups. UCN3 levels showed a positive correlation with BMI in both 
      groups. Moreover, UCN3 levels were positively and independently associated with 
      insulin, fasting blood glucose, insulin resistance, 2-hour plasma glucose, 
      glycosylated hemoglobin, and triglycerides, whereas UCN3 levels were negatively 
      and independently associated with high-density lipoprotein cholesterol. According 
      to logistic regression analysis, increased risk of T2DM and metabolic syndrome 
      were parallel with the highest elevated levels of UCN3. CONCLUSIONS: Increased 
      levels of UCN3 are associated with unfavorable metabolic profiles in T2DM, 
      indicating a potential role of UCN3 in glucose and lipid metabolisms in T2DM.
CI  - (c) 2020 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Alarslan, Pinar
AU  - Alarslan P
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir 
      Bozyaka Training and Research Hospital, Izmir, Turkey.
FAU - Unal Kocabas, Gokcen
AU  - Unal Kocabas G
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir 
      Bozyaka Training and Research Hospital, Izmir, Turkey.
FAU - Demir, Ismail
AU  - Demir I
AD  - Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 
      Izmir, Turkey.
FAU - Guler, Asli
AU  - Guler A
AD  - Department of Family Physician, Izmir Bozyaka Training and Research Hospital, 
      Izmir, Turkey.
FAU - Bozkaya, Giray
AU  - Bozkaya G
AD  - Department of Clinical Biochemistry, Izmir Bozyaka Training and Research 
      Hospital, Izmir, Turkey.
FAU - Aslanipour, Behnaz
AU  - Aslanipour B
AD  - Department of Biotechnology, Graduate School of Natural and Applied Sciences, Ege 
      University, Izmir, Turkey.
FAU - Calan, Mehmet
AU  - Calan M
AUID- ORCID: 0000-0002-5614-0710
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir 
      Bozyaka Training and Research Hospital, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200113
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Urocortins)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Urocortins/*blood
OTO - NOTNLM
OT  - body mass index
OT  - insulin resistance
OT  - newly diagnosed type 2 diabetes mellitus
OT  - urocortin 3
OT  - 体重指数
OT  - 尿皮质激素3
OT  - 新诊断2型糖尿病
OT  - 胰岛素抵抗
EDAT- 2020/01/02 06:00
MHDA- 2021/02/26 06:00
CRDT- 2020/01/02 06:00
PHST- 2019/06/21 00:00 [received]
PHST- 2019/12/07 00:00 [revised]
PHST- 2019/12/29 00:00 [accepted]
PHST- 2020/01/02 06:00 [pubmed]
PHST- 2021/02/26 06:00 [medline]
PHST- 2020/01/02 06:00 [entrez]
AID - 10.1111/1753-0407.13020 [doi]
PST - ppublish
SO  - J Diabetes. 2020 Jun;12(6):474-482. doi: 10.1111/1753-0407.13020. Epub 2020 Jan 
      13.