PMID- 31894370
OWN - NLM
STAT- MEDLINE
DCOM- 20200424
LR  - 20200424
IS  - 1432-0800 (Electronic)
IS  - 0007-4861 (Linking)
VI  - 104
IP  - 2
DP  - 2020 Feb
TI  - Immunohistological Biomarkers of Toxicity by a Pharmaceutical Antidepressant in 
      the Freshwater Cichlid Fish Cichlasoma dimerus (Teleostei, Cichliformes).
PG  - 180-184
LID - 10.1007/s00128-019-02770-3 [doi]
AB  - Melano-macrophage centers (MMCs) are nodular clusters of pigmented macrophages, 
      implicated in homeostasis and destruction and recycling of endogenous and 
      exogenous material. They can increase in size and/or frequency under 
      environmental stress resulting in immunohistological biomarkers of water quality. 
      Fluoxetine (FLX), a commonly prescribed antidepressant, can cause neuroendocrine, 
      behavioral and reproductive alterations in teleost fish. In the present study, we 
      analyzed the effects of a 2-week 50 microg/L FLX exposure on MMCs in histological 
      sections of spleen and head-kidney (HK) of the cichlid fish Cichlasoma dimerus. 
      In the spleen, FLX caused an increase in the area and a decrease in the number of 
      MMCs. An increase in the proportion of the HK occupied by MMCs was observed in 
      FLX-exposed fish, due to an increase in their number but not their area. The 
      deposition rate of MMCs varies according to the hemolymphopoietic organ and would 
      be the result of a differential response to FLX on homeostatic functions 
      (elimination of cellular debris, iron processing and immune response).
FAU - Rey Vazquez, Graciela
AU  - Rey Vazquez G
AD  - Laboratorio de Ecotoxicologia Acuatica, Instituto de Biodiversidad y Biologia 
      Experimental Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, 
      Argentina.
AD  - Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y 
      Biologia Experimental Aplicada, Universidad de Buenos Aires, Buenos Aires, 
      Argentina.
FAU - Da Cuna, Rodrigo Hernan
AU  - Da Cuna RH
AD  - Laboratorio de Ecotoxicologia Acuatica, Instituto de Biodiversidad y Biologia 
      Experimental Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, 
      Argentina.
AD  - Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y 
      Biologia Experimental Aplicada, Universidad de Buenos Aires, Buenos Aires, 
      Argentina.
FAU - Dorelle, Luciana Soledad
AU  - Dorelle LS
AD  - Laboratorio de Ecotoxicologia Acuatica, Instituto de Biodiversidad y Biologia 
      Experimental Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, 
      Argentina.
AD  - Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y 
      Biologia Experimental Aplicada, Universidad de Buenos Aires, Buenos Aires, 
      Argentina.
FAU - Lo Nostro, Fabiana Laura
AU  - Lo Nostro FL
AUID- ORCID: 0000-0001-8816-9449
AD  - Laboratorio de Ecotoxicologia Acuatica, Instituto de Biodiversidad y Biologia 
      Experimental Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, 
      Argentina. f.lonostro@gmail.com.
AD  - Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y 
      Biologia Experimental Aplicada, Universidad de Buenos Aires, Buenos Aires, 
      Argentina. f.lonostro@gmail.com.
LA  - eng
GR  - PICT2016-0432/Fondo para la Investigacion Cientifica y Tecnologica/
GR  - UBACyT 0672/UBA/
PT  - Journal Article
DEP - 20200101
PL  - United States
TA  - Bull Environ Contam Toxicol
JT  - Bulletin of environmental contamination and toxicology
JID - 0046021
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Water Pollutants, Chemical)
RN  - 01K63SUP8D (Fluoxetine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*toxicity
MH  - Biomarkers/metabolism
MH  - Cichlids/growth & development/metabolism/physiology
MH  - Fluoxetine/*toxicity
MH  - Fresh Water/chemistry
MH  - Head Kidney/drug effects/metabolism
MH  - Immunohistochemistry
MH  - Spleen/drug effects/metabolism
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Fluoxetine
OT  - Head kidney
OT  - Hematopoietic tissue
OT  - Melano-macrophage centers
OT  - Spleen
EDAT- 2020/01/03 06:00
MHDA- 2020/04/25 06:00
CRDT- 2020/01/03 06:00
PHST- 2019/08/10 00:00 [received]
PHST- 2019/12/13 00:00 [accepted]
PHST- 2020/01/03 06:00 [pubmed]
PHST- 2020/04/25 06:00 [medline]
PHST- 2020/01/03 06:00 [entrez]
AID - 10.1007/s00128-019-02770-3 [pii]
AID - 10.1007/s00128-019-02770-3 [doi]
PST - ppublish
SO  - Bull Environ Contam Toxicol. 2020 Feb;104(2):180-184. doi: 
      10.1007/s00128-019-02770-3. Epub 2020 Jan 1.