PMID- 31894843
OWN - NLM
STAT- MEDLINE
DCOM- 20210315
LR  - 20231113
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 40
IP  - 2
DP  - 2020 Feb 28
TI  - The effect of wuling capsule on depression in Type 2 diabetic patients.
LID - 10.1042/BSR20191260 [doi]
LID - BSR20191260
AB  - OBJECTIVE: Depression is a common complication in Type 2 diabetes mellitus 
      (T2DM); however, it has long been underrecognized and undertreated. In the 
      present study, we aimed to evaluate the clinical effects of Wuling capsule, a 
      compound traditional Chinese herbal medicine, on T2DM complicated with 
      depression. METHOD: 66 patients were enrolled and randomly divided into Wuling 
      capsule treatment group and placebo group, and finally 64 cases finished the 
      present study. The levels of FPG, 2hPG, HbAlc, TNF-alpha, IL-6, SOD, MDA, Cor, ACTH, 
      HOMA-beta, HOMA-IR and ISI of patients were evaluated and compared. The HAMD scale 
      for patients were recorded. RESULT: After 12-week treatment, the HAMD scale 
      decreased in both groups, and was lower in Wuling capsule group. The level of FPG 
      in Wuling capsule group was significantly lower than in placebo group; however, 
      no obvious changes of 2hPG and HbA1c were found. The levels of IL-6 and TNF-alpha 
      were significantly decreased in both groups, and more obviously in Wuling capsule 
      group. The level of SOD was increased while the level of MDA was decreased 
      significantly in both groups, and the changes were more obviously in Wuling 
      capsule group. The levels of Cor and ACTH were significantly decreased in both 
      groups; however, there was no statistically significance between the two groups. 
      Besides, the comparisons of HOMA-beta, HOMA-IR and ISI between the two groups were 
      not statistically significant. CONCLUSION: Our results suggested that Wuling 
      capsule ameliorated the depression in patients with T2DM, and also improved the 
      state of inflammation and oxidative stress state. These results also strongly 
      indicated the ability of clinical transformation of Wuling capsule in patients 
      with T2DM in the future.
CI  - (c) 2020 The Author(s).
FAU - Wang, Huanping
AU  - Wang H
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Chen, Huizhen
AU  - Chen H
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Gao, Yang
AU  - Gao Y
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Wang, Shengju
AU  - Wang S
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Wang, Xian
AU  - Wang X
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Tang, Xiaomei
AU  - Tang X
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Fang, Wei
AU  - Fang W
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Shi, Xiaoyan
AU  - Shi X
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Yao, Jia
AU  - Yao J
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
FAU - Chen, Qiu
AU  - Chen Q
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Inflammation Mediators)
RN  - 0 (wuling)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenal Glands/drug effects/metabolism
MH  - Adrenocorticotropic Hormone/blood
MH  - Affect/*drug effects
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Antidepressive Agents/*therapeutic use
MH  - Antioxidants/therapeutic use
MH  - Biomarkers/blood
MH  - China
MH  - Depression/blood/*drug therapy/etiology/psychology
MH  - Diabetes Mellitus, Type 2/blood/complications/*drug therapy
MH  - Double-Blind Method
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Hypothalamo-Hypophyseal System/drug effects/metabolism
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/drug effects
MH  - Treatment Outcome
PMC - PMC7029151
OTO - NOTNLM
OT  - Depression
OT  - Inflammatory factors
OT  - Oxidative stress
OT  - Type 2 diabetes mellitus
OT  - Wuling capsule
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2020/01/03 06:00
MHDA- 2021/03/16 06:00
PMCR- 2020/02/18
CRDT- 2020/01/03 06:00
PHST- 2019/05/11 00:00 [received]
PHST- 2019/12/03 00:00 [revised]
PHST- 2019/12/19 00:00 [accepted]
PHST- 2020/01/03 06:00 [pubmed]
PHST- 2021/03/16 06:00 [medline]
PHST- 2020/01/03 06:00 [entrez]
PHST- 2020/02/18 00:00 [pmc-release]
AID - 221737 [pii]
AID - BSR20191260 [pii]
AID - 10.1042/BSR20191260 [doi]
PST - ppublish
SO  - Biosci Rep. 2020 Feb 28;40(2):BSR20191260. doi: 10.1042/BSR20191260.