PMID- 31895598
OWN - NLM
STAT- MEDLINE
DCOM- 20210614
LR  - 20231213
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Linking)
VI  - 40
IP  - 3
DP  - 2020 Mar
TI  - Interleukin-22 in Allergic Airway Diseases: A Systematic Review.
PG  - 125-130
LID - 10.1089/jir.2019.0094 [doi]
AB  - The immune system plays an important role in the pathogenesis of many disorders, 
      including allergic airway diseases. There are studies suggesting that interleukin 
      (IL)-22 can be important in the development of these diseases. However, it is not 
      known if this cytokine acts as proinflammatory or anti-inflammatory agent. This 
      systematic review aimed to analyze level and role of IL-22 in patients with 
      allergic airway diseases in comparison with healthy individuals. Systematic 
      review included only observational studies with patients having allergic rhinitis 
      and/or allergic asthma. The primary outcome measure was IL-22 level in patients 
      with allergic asthma and/or allergic rhinitis. A total of 95 articles were found. 
      Overall, 6 articles were included in systematic review. Five of these studies 
      showed that IL-22 was increased in patients with allergic airway diseases 
      compared with control group. Majority of studies revealed relation between IL-22 
      level and severity of allergic asthma and allergic rhinitis. Some studies showed 
      positive relation between IL-22 level and total immunoglobulin E (IgE), specific 
      IgE, and eosinophil count in nasal mucosa. IL-22 level is increased in children 
      and adults with allergic airway diseases and is likely to be associated with 
      proinflammatory features.
FAU - Tamasauskiene, Laura
AU  - Tamasauskiene L
AD  - Department of Immunology and Allergology, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania.
FAU - Sitkauskiene, Brigita
AU  - Sitkauskiene B
AD  - Department of Immunology and Allergology, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20191231
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Biomarkers)
RN  - 0 (Interleukins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/diagnosis/etiology/metabolism
MH  - *Biomarkers
MH  - *Disease Susceptibility
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Interleukins/blood/*metabolism
MH  - Leukocyte Count
MH  - Respiratory Hypersensitivity/diagnosis/*etiology/*metabolism
MH  - Rhinitis, Allergic/diagnosis/etiology/metabolism
MH  - Severity of Illness Index
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Interleukin-22
OTO - NOTNLM
OT  - airway
OT  - allergy
OT  - asthma
OT  - interleukin-22
OT  - rhinitis
EDAT- 2020/01/03 06:00
MHDA- 2021/06/16 06:00
CRDT- 2020/01/03 06:00
PHST- 2020/01/03 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2020/01/03 06:00 [entrez]
AID - 10.1089/jir.2019.0094 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2020 Mar;40(3):125-130. doi: 10.1089/jir.2019.0094. 
      Epub 2019 Dec 31.