PMID- 31895788
OWN - NLM
STAT- MEDLINE
DCOM- 20200114
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 1
DP  - 2020 Jan
TI  - Association between atopic dermatitis and colorectal cancer risk: A nationwide 
      cohort study.
PG  - e18530
LID - 10.1097/MD.0000000000018530 [doi]
LID - e18530
AB  - The role of atopic dermatitis (AD) in the development of colorectal cancer (CRC) 
      has been a matter of scientific debate with mixed results. We conducted a 
      nationwide cohort study to assess the association between AD and risk of CRC. 
      Drawing on Taiwan's National Health Insurance Research Database, 46,703 patients 
      with AD (the AD cohort) and 186,812 sex, age, and index year-matched patients 
      without AD (the non-AD cohort) were identified in the period between 2000 and 
      2008. Follow-up time was calculated from the date of entry in the cohort until 
      the occurrence of a first CRC diagnosis, death, or the end of the observation 
      period (December 31, 2013), whichever occurred first. Hazards ratios (HRs) and 
      accompanying 95% confidence intervals (CIs) derived from the Fine-Gray competing 
      risk model were used to estimate the association between AD and CRC risk. After 
      multivariable adjustment, AD was associated with an increased risk of CRC 
      (adjusted HR, 1.26; 95% CI, 1.14-1.40). Of note, a significant positive 
      association between AD and CRC risk was evident in both men and women and in all 
      age groups. In summary, this population-based cohort study revealed that AD was 
      associated with an increased risk of CRC in an Asian population. It will be of 
      interest for cohort studies with prediagnostic specimens to evaluate the 
      potential relationship between AD and CRC using biomarkers for allergy status.
FAU - Chou, Wan-Yun
AU  - Chou WY
AD  - Graduate Institute of Life Sciences.
FAU - Lai, Pin-Yu
AU  - Lai PY
AD  - School of Public Health.
FAU - Hu, Je-Ming
AU  - Hu JM
AD  - Graduate Institute of Medical Sciences.
AD  - Division of Colorectal Surgery, Department of Surgery, Tri-Service General 
      Hospital.
AD  - School of Medicine.
FAU - Hsu, Chih-Hsiung
AU  - Hsu CH
AD  - Graduate Institute of Medical Sciences.
AD  - Teaching Office, Tri-Service General Hospital, National Defense Medical Center, 
      Taipei City.
FAU - Chen, Yong-Chen
AU  - Chen YC
AD  - Department of Medicine.
AD  - Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New 
      Taipei City.
FAU - Tian, Yu-Feng
AU  - Tian YF
AD  - Division of Colorectal Surgery, Department of Surgery, Chi-Mei Medical Center.
AD  - Department of Health & Nutrition, Chia Nan University of Pharmacy and Science, 
      Tainan City.
FAU - You, San-Lin
AU  - You SL
AD  - Department of Medicine.
AD  - Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New 
      Taipei City.
FAU - Hsiao, Cheng-Wen
AU  - Hsiao CW
AD  - Division of Colorectal Surgery, Department of Surgery, Tri-Service General 
      Hospital.
FAU - Chou, Yu-Ching
AU  - Chou YC
AD  - Graduate Institute of Life Sciences.
AD  - School of Public Health.
FAU - Sun, Chien-An
AU  - Sun CA
AD  - Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New 
      Taipei City.
AD  - Department of Public Health, College of Medicine, Fu-Jen Catholic University, New 
      Taipei City, Taiwan.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Colorectal Neoplasms/*epidemiology/etiology
MH  - Databases, Factual
MH  - Dermatitis, Atopic/*complications
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Taiwan/epidemiology
MH  - Young Adult
PMC - PMC6946374
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/01/03 06:00
MHDA- 2020/01/15 06:00
PMCR- 2020/01/03
CRDT- 2020/01/03 06:00
PHST- 2020/01/03 06:00 [entrez]
PHST- 2020/01/03 06:00 [pubmed]
PHST- 2020/01/15 06:00 [medline]
PHST- 2020/01/03 00:00 [pmc-release]
AID - 00005792-202001030-00025 [pii]
AID - MD-D-19-00975 [pii]
AID - 10.1097/MD.0000000000018530 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Jan;99(1):e18530. doi: 10.1097/MD.0000000000018530.