PMID- 31897585
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1619-7089 (Electronic)
IS  - 1619-7070 (Linking)
VI  - 47
IP  - 7
DP  - 2020 Jul
TI  - Relationship between coronary arterial (18)F-sodium fluoride uptake and 
      epicardial adipose tissue analyzed using computed tomography.
PG  - 1746-1756
LID - 10.1007/s00259-019-04675-z [doi]
AB  - PURPOSE: (18)F-Sodium fluoride ((18)F-NaF) positron emission tomography (PET) has 
      the potential to detect high-risk coronary plaques. Epicardial adipose tissue 
      (EAT) reportedly correlates with coronary atherosclerosis progression. We 
      evaluated the relationship between coronary arterial (18)F-NaF uptake and EAT 
      findings using computed tomography (CT). METHODS: We studied 40 patients with >/= 1 
      coronary plaque detected on cardiac CT who underwent (18)F-NaF PET/CT. EAT volume 
      was measured using CT and indexed to body surface area in each patient. Each 
      plaque was evaluated for CT-based luminal stenosis and high-risk features. The 
      mean EAT density surrounding each plaque was calculated as perilesional EAT 
      density (PLED) using non-contrast CT images. Focal (18)F-NaF uptake in each 
      plaque was quantified using the maximum tissue-to-background ratio (TBR(max)). 
      RESULTS: EAT volume index was similar between patients with TBR(max) >/= 1.28 
      (previously reported optimal cutoff to predict coronary events) and those with 
      lower TBR(max), but patients with TBR(max) >/= 1.28 showed higher maximum PLED per 
      patient (- 86 +/- 12 Hounsfield units (HU) versus - 98 +/- 11 HU, P = 0.0044). In the 
      lesion-based analysis (n = 92), PLED was positively correlated with TBR(max), and 
      the optimal PLED cutoff to identify TBR(max) >/= 1.28 was - 97 HU. On multivariate 
      analysis adjusted for lesion location, obstructive stenosis, and high-risk plaque 
      on CT, PLED >/= - 97 HU remained a significant predictor of TBR(max) >/= 1.28. 
      CONCLUSIONS: Increased PLED was associated with significant coronary arterial 
      (18)F-NaF uptake. Step-by-step analyses of EAT density on CT and coronary 
      arterial (18)F-NaF uptake on PET may offer novel strategies for risk prediction 
      in coronary artery disease.
FAU - Kitagawa, Toshiro
AU  - Kitagawa T
AUID- ORCID: 0000-0002-5433-2428
AD  - Department of Cardiovascular Medicine, Hiroshima University Graduate School of 
      Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, 
      Japan. toshirok@hiroshima-u.ac.jp.
FAU - Nakamoto, Yumiko
AU  - Nakamoto Y
AD  - Department of Cardiovascular Medicine, Hiroshima University Graduate School of 
      Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, 
      Japan.
FAU - Fujii, Yuto
AU  - Fujii Y
AD  - Department of Cardiovascular Medicine, Hiroshima University Graduate School of 
      Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, 
      Japan.
FAU - Sasaki, Ko
AU  - Sasaki K
AD  - Hiroshima Heiwa Clinic, Hiroshima, Japan.
FAU - Tatsugami, Fuminari
AU  - Tatsugami F
AD  - Department of Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, 
      Japan.
FAU - Awai, Kazuo
AU  - Awai K
AD  - Department of Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, 
      Japan.
FAU - Hirokawa, Yutaka
AU  - Hirokawa Y
AD  - Hiroshima Heiwa Clinic, Hiroshima, Japan.
FAU - Kihara, Yasuki
AU  - Kihara Y
AD  - Department of Cardiovascular Medicine, Hiroshima University Graduate School of 
      Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200102
PL  - Germany
TA  - Eur J Nucl Med Mol Imaging
JT  - European journal of nuclear medicine and molecular imaging
JID - 101140988
RN  - 0 (Fluorine Radioisotopes)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - GZ5I74KB8G (Fluorine-18)
SB  - IM
MH  - *Adipose Tissue/diagnostic imaging
MH  - Aged
MH  - *Coronary Artery Disease/diagnostic imaging
MH  - *Coronary Vessels/diagnostic imaging/metabolism
MH  - Female
MH  - Fluorine Radioisotopes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pericardium/diagnostic imaging
MH  - *Plaque, Atherosclerotic
MH  - Positron Emission Tomography Computed Tomography
MH  - Sodium Fluoride
MH  - *Tomography, X-Ray Computed
OTO - NOTNLM
OT  - 18F-sodium fluoride PET
OT  - Coronary CT
OT  - Coronary artery disease
OT  - Coronary atherosclerosis
OT  - Epicardial adipose tissue
EDAT- 2020/01/04 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/01/04 06:00
PHST- 2019/11/19 00:00 [received]
PHST- 2019/12/26 00:00 [accepted]
PHST- 2020/01/04 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/01/04 06:00 [entrez]
AID - 10.1007/s00259-019-04675-z [pii]
AID - 10.1007/s00259-019-04675-z [doi]
PST - ppublish
SO  - Eur J Nucl Med Mol Imaging. 2020 Jul;47(7):1746-1756. doi: 
      10.1007/s00259-019-04675-z. Epub 2020 Jan 2.