PMID- 31898280
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20210110
IS  - 1473-4230 (Electronic)
IS  - 1473-4222 (Linking)
VI  - 19
IP  - 2
DP  - 2020 Apr
TI  - Selective Cerebellar Atrophy Associates with Depression and Fatigue in the Early 
      Phases of Relapse-Onset Multiple Sclerosis.
PG  - 192-200
LID - 10.1007/s12311-019-01096-4 [doi]
AB  - Cerebellar dysfunctions have been associated to depressive disorders and 
      cognitive impairment in neurodegenerative diseases. The objective is to analyze 
      the associations between cerebellar atrophy, depression, and fatigue in the early 
      phases of relapse-onset multiple sclerosis (RRMS). Sixty-one RRMS patients and 50 
      healthy controls (HC) were enrolled and clinically evaluated by means of expanded 
      disability status scale (EDSS), Rao's brief repeatable battery of 
      neuropsychological tests (BRB-NT), Delis-Kaplan executive function system sorting 
      test, beck depression inventory II (BDI-II), and fatigue severity scale (FSS). 
      The relationships between MRI variables and clinical scores were assessed. 
      Depressed RRMS (dRRMS) had significantly lower Vermis Crus I volume compared with 
      not depressed RRMS (ndRRMS) (p = 0.009). Vermis Crus I volume was lower in dRRMS 
      suffering from fatigue than in ndRRMS without fatigue (p = 0.01). The 
      hierarchical regression models which included demographic and clinical data (age, 
      sex, and disease duration, FSS or BDI-II) and cerebellar volumes disclosed that 
      cerebellar lobule right V atrophy explained an increase of 4% of the variability 
      in FSS (p = 0.25) and Vermis Crus I atrophy explained an increase of 6% of 
      variability in BDI-II (p = 0.049). Since clinical onset, atrophy of specific 
      cerebellar lobules associates with important clinical aspects of RRMS. Cerebellar 
      pathology may be one of the determinants of fatigue and depression that 
      contribute to worsen disability in RRMS.
FAU - Lazzarotto, Andrea
AU  - Lazzarotto A
AUID- ORCID: 0000-0002-5109-8533
AD  - Multiple Sclerosis Centre of the Veneto Region, Padua, Italy. 
      andrea.lazzarotto89@gmail.com.
AD  - Department of Neuroscience, University Hospital of Padua, Giustiniani 5, 35100, 
      Padua, Italy. andrea.lazzarotto89@gmail.com.
AD  - Padova Neuroscience Center-PNC, Padua, Italy. andrea.lazzarotto89@gmail.com.
FAU - Margoni, Monica
AU  - Margoni M
AD  - Multiple Sclerosis Centre of the Veneto Region, Padua, Italy.
AD  - Department of Neuroscience, University Hospital of Padua, Giustiniani 5, 35100, 
      Padua, Italy.
AD  - Padova Neuroscience Center-PNC, Padua, Italy.
FAU - Franciotta, Silvia
AU  - Franciotta S
AD  - Multiple Sclerosis Centre of the Veneto Region, Padua, Italy.
AD  - Department of Neuroscience, University Hospital of Padua, Giustiniani 5, 35100, 
      Padua, Italy.
FAU - Zywicki, Sofia
AU  - Zywicki S
AD  - Multiple Sclerosis Centre of the Veneto Region, Padua, Italy.
AD  - Department of Neuroscience, University Hospital of Padua, Giustiniani 5, 35100, 
      Padua, Italy.
FAU - Riccardi, Alice
AU  - Riccardi A
AD  - Multiple Sclerosis Centre of the Veneto Region, Padua, Italy.
AD  - Department of Neuroscience, University Hospital of Padua, Giustiniani 5, 35100, 
      Padua, Italy.
FAU - Poggiali, Davide
AU  - Poggiali D
AD  - Department of Mathematics, University of Padua, Padua, Italy.
FAU - Anglani, Mariagiulia
AU  - Anglani M
AD  - Neuroradiology Unit, University Hospital of Padua, Padua, Italy.
FAU - Gallo, Paolo
AU  - Gallo P
AD  - Multiple Sclerosis Centre of the Veneto Region, Padua, Italy.
AD  - Department of Neuroscience, University Hospital of Padua, Giustiniani 5, 35100, 
      Padua, Italy.
AD  - Padova Neuroscience Center-PNC, Padua, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cerebellum
JT  - Cerebellum (London, England)
JID - 101089443
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Atrophy/pathology
MH  - Cerebellum/*pathology
MH  - Depression/*etiology
MH  - Fatigue/*etiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*complications/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - Cerebellum
OT  - Depression
OT  - Fatigue
OT  - Multiple sclerosis
OT  - Neuroimaging
EDAT- 2020/01/04 06:00
MHDA- 2020/11/24 06:00
CRDT- 2020/01/04 06:00
PHST- 2020/01/04 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
PHST- 2020/01/04 06:00 [entrez]
AID - 10.1007/s12311-019-01096-4 [pii]
AID - 10.1007/s12311-019-01096-4 [doi]
PST - ppublish
SO  - Cerebellum. 2020 Apr;19(2):192-200. doi: 10.1007/s12311-019-01096-4.