PMID- 31898649
OWN - NLM
STAT- MEDLINE
DCOM- 20200529
LR  - 20220412
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 15
IP  - 6
DP  - 2019 Oct-Dec
TI  - Dosimetric comparison of (60)Co and (192)Ir high dose rate source used in 
      brachytherapy treatment of cervical cancer.
PG  - 1212-1215
LID - 10.4103/jcrt.JCRT_372_19 [doi]
AB  - PURPOSE: The study purpose included dosimetric comparison of cobalt 60 ((60)Co) 
      and iridium 192 ((192)Ir) high dose rate (HDR) source used in brachytherapy 
      treatment of cervical cancer. MATERIALS AND METHODS: Computed tomography (CT) 
      scans for 15 patients of carcinoma of uterine cervix using 3-mm slice thickness 
      were considered for the study The contouring of high-risk clinical target volume 
      (HRCTV), bladder, and rectum on CT images was done as per the GEC ESTRO 
      guidelines with the help of magnetic resonance imaging images in the treatment 
      planning system. All parameters were kept the same for (60)Co (3.5 mm active 
      length, 0.5 mm active dia, Bebig) and (192)Ir (3.5 mm active length, 0.6 mm 
      active dia, Bebig) HDR source with 2.5-mm step size and dose prescription to 
      Point A. As per the International Commission on Radiation Unit (ICRU)-89 
      guidelines, the dose-volume parameters such as D(50)(Gy), D(90)(Gy), and 
      D(98)(Gy) for HRCTV and D(0.1cc) (Gy), D(1cc) (Gy), D(2cc) (Gy), and D(5cc) (Gy) 
      to the bladder and rectum were calculated for both the HDR sources. RESULTS: The 
      difference in dose-volume histogram parameters such as D(50,)D(90,)and D(98) of 
      HRCTV was 3.19%, 1.13%, and 0.50%, respectively, for the two radioisotopes. The 
      difference in dose values of D(0.1cc), D(1cc), D(2cc), D(5cc), and ICRU reference 
      points of bladder was -0.58%, -0.67%, -0.99%, -0.94%, and -1.75%, respectively. 
      On the other hand, dose difference for D(0.1cc), D(1cc), D(2cc), D(5cc), and ICRU 
      reference points of rectum was 0.67%, 0.26%, 0.56%, 0.63%, and -0.33%, 
      respectively. CONCLUSIONS: The present study results show that all the dose 
      parameters of HRCTV, bladder, and rectum with (60)Co were comparable with those 
      of (192)Ir HDR source. The isodose distribution is more bulge out for (60)Co in 
      cranial-caudal direction compared to that of (192)Ir. However, these differences 
      can be reduced by treatment planning optimization techniques. The clinical plan 
      evaluation in each slice and plane is necessary to explore the logistic and 
      financial benefits of miniaturized (60)Co source over (192)Ir HDR source.
FAU - Shukla, Arvind Kumar
AU  - Shukla AK
AD  - Department of Radiotherapy, RNT Medical College, Udaipur, Rajasthan, India.
FAU - Jangid, Pawan Kumar
AU  - Jangid PK
AD  - Department of Radiotherapy, RNT Medical College, Udaipur, Rajasthan, India.
FAU - Rajpurohit, Vikram Singh
AU  - Rajpurohit VS
AD  - Department of Radiotherapy, RNT Medical College, Udaipur, Rajasthan, India.
FAU - Verma, Atul
AU  - Verma A
AD  - Department of Radiotherapy, RNT Medical College, Udaipur, Rajasthan, India.
FAU - Dangayach, Suresh Kumar
AU  - Dangayach SK
AD  - Department of Radiotherapy, RNT Medical College, Udaipur, Rajasthan, India.
FAU - Gagrani, Vaibhav
AU  - Gagrani V
AD  - Department of Radiotherapy, RNT Medical College, Udaipur, Rajasthan, India.
FAU - Rathore, Narendra Kumar
AU  - Rathore NK
AD  - Department of Radiotherapy, RNT Medical College, Udaipur, Rajasthan, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
RN  - 0 (Cobalt Radioisotopes)
RN  - 0 (Iridium Radioisotopes)
RN  - 0 (Iridium-192)
RN  - 5C8182XDPZ (Cobalt-60)
SB  - IM
MH  - *Brachytherapy/adverse effects/methods
MH  - Cobalt Radioisotopes/*administration & dosage
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Humans
MH  - Iridium Radioisotopes/*administration & dosage
MH  - Organs at Risk
MH  - *Radiometry
MH  - *Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Image-Guided
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Uterine Cervical Neoplasms/diagnosis/*radiotherapy
OTO - NOTNLM
OT  - Brachytherapy
OT  - cervical cancer
OT  - cobalt-60 source
OT  - high dose rate
OT  - iridium-192 source
COIS- None
EDAT- 2020/01/04 06:00
MHDA- 2020/05/30 06:00
CRDT- 2020/01/04 06:00
PHST- 2020/01/04 06:00 [entrez]
PHST- 2020/01/04 06:00 [pubmed]
PHST- 2020/05/30 06:00 [medline]
AID - JCanResTher_2019_15_6_1212_273853 [pii]
AID - 10.4103/jcrt.JCRT_372_19 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2019 Oct-Dec;15(6):1212-1215. doi: 10.4103/jcrt.JCRT_372_19.