PMID- 31898833
OWN - NLM
STAT- MEDLINE
DCOM- 20201216
LR  - 20201216
IS  - 1439-0396 (Electronic)
IS  - 0931-2439 (Linking)
VI  - 104
IP  - 2
DP  - 2020 Mar
TI  - Therapeutic effects of saponin components on porcine reproductive and respiratory 
      syndrome virus-infected piglets.
PG  - 637-644
LID - 10.1111/jpn.13302 [doi]
AB  - The present study aimed to evaluate the potential therapeutic effects of 
      Anemoside B4 (AB4), Panax notoginseng saponins (PNS), Notoginsenoside R1 (SR1), 
      Saikosaponin A (SSA) and Saikosaponin D (SSD) on piglets infected with porcine 
      reproductive and respiratory syndrome virus (PRRSV). A total of 132 completely 
      healthy piglets were randomly divided into 22 groups consisting of six animals 
      each. Control piglets were intramuscularly injected with 2 ml of PRRSV (NJGC 
      strain) solution containing 10(6)  TCID(50)  virus/ml. For low-, middle- and 
      high-dose saponin treatment groups, the piglets were initially administrated with 
      the same volume of PRRSV solution, followed by intraperitoneal injection with 
      AB4, PNS, SR1, SSA or SSD at 1, 5 or 10 mg/kg b.w. on day 3. The piglets in drug 
      control group were intraperitoneally injected with 10 mg/kg b.w. of each saponin 
      without prior PRRS challenge, while those in blank control group were injected 
      with the same amount of normal saline. The results indicated that all the five 
      saponin components could decrease the incidence and severity of PRRSV-induced 
      immunopathological damages, including the elevated body temperature, weight loss, 
      anaemia and internal inflammation. Moreover, the saponin components could enhance 
      protein absorption and immune responses. Taken together, this study reveals that 
      the saponin components are effective against PRRSV infection and strengthen the 
      immune system and thus may serve as potential antiviral therapeutic agents.
CI  - (c) 2020 Blackwell Verlag GmbH.
FAU - Hu, Yiyi
AU  - Hu Y
AUID- ORCID: 0000-0002-3781-5540
AD  - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory 
      Cultivation Base of Ministry of Science and Technology, Institute of Veterinary 
      Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
AD  - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal 
      Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.
FAU - Zhang, Bicheng
AU  - Zhang B
AD  - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory 
      Cultivation Base of Ministry of Science and Technology, Institute of Veterinary 
      Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
AD  - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal 
      Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory 
      Cultivation Base of Ministry of Science and Technology, Institute of Veterinary 
      Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
AD  - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal 
      Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.
FAU - Zhou, Jinzhu
AU  - Zhou J
AD  - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory 
      Cultivation Base of Ministry of Science and Technology, Institute of Veterinary 
      Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
AD  - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal 
      Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.
FAU - Li, Bin
AU  - Li B
AD  - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory 
      Cultivation Base of Ministry of Science and Technology, Institute of Veterinary 
      Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
AD  - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal 
      Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.
FAU - He, Kongwang
AU  - He K
AD  - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory 
      Cultivation Base of Ministry of Science and Technology, Institute of Veterinary 
      Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
AD  - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal 
      Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.
LA  - eng
GR  - 2018YFD0500101/National Key Research and Development Program/
GR  - 31502112/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20200103
PL  - Germany
TA  - J Anim Physiol Anim Nutr (Berl)
JT  - Journal of animal physiology and animal nutrition
JID - 101126979
RN  - 0 (Hemoglobins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Saponins)
SB  - IM
MH  - Animals
MH  - Blood Platelets
MH  - Drug Tapering
MH  - Erythrocyte Count
MH  - Hemoglobins
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Leukocyte Count
MH  - Magnoliopsida/chemistry
MH  - Male
MH  - Porcine Reproductive and Respiratory Syndrome/*drug therapy
MH  - Porcine respiratory and reproductive syndrome virus
MH  - Saponins/administration & dosage/chemistry/*therapeutic use
MH  - Swine
OTO - NOTNLM
OT  - albumin
OT  - antivirus
OT  - haemoglobin
OT  - immune
OT  - immunoglobulin G
EDAT- 2020/01/04 06:00
MHDA- 2020/12/17 06:00
CRDT- 2020/01/04 06:00
PHST- 2019/08/27 00:00 [received]
PHST- 2019/10/14 00:00 [revised]
PHST- 2019/12/06 00:00 [accepted]
PHST- 2020/01/04 06:00 [pubmed]
PHST- 2020/12/17 06:00 [medline]
PHST- 2020/01/04 06:00 [entrez]
AID - 10.1111/jpn.13302 [doi]
PST - ppublish
SO  - J Anim Physiol Anim Nutr (Berl). 2020 Mar;104(2):637-644. doi: 10.1111/jpn.13302. 
      Epub 2020 Jan 3.