PMID- 31899165
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20201116
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 103
IP  - Pt A
DP  - 2020 Feb
TI  - PedsQL Cognitive Functioning Scale in youth with epilepsy: Reliability and 
      validity.
PG  - 106850
LID - S1525-5050(19)31079-0 [pii]
LID - 10.1016/j.yebeh.2019.106850 [doi]
AB  - OBJECTIVE: The objective of the study was to report on the internal consistency 
      reliability and discriminant, concurrent and construct validity of the Pediatric 
      Quality of Life Inventory (PedsQL) Cognitive Functioning Scale as a brief 
      generic cognitive functioning measure in youth with epilepsy. METHODS: The 6-item 
      PedsQL Cognitive Functioning Scale and 23-item PedsQL 4.0 Generic Core Scales 
      were completed by 221 pediatric patients ages 5-18 years with epilepsy and 336 
      parents of patients ages 2-18 years in a national field test study for the 
      PedsQL Epilepsy Module. Parents also completed the 86-item Behavior Rating 
      Inventory of Executive Function (BRIEF), a widely validated measure of executive 
      functioning. RESULTS: The PedsQL Cognitive Functioning Scale evidenced excellent 
      reliability (patient self-report alpha = 0.88; parent proxy-report alpha = 0.96), 
      distinguished between youth with epilepsy and an age, gender, and 
      race/ethnicity-matched healthy sample supporting discriminant validity with large 
      effect sizes (~20-30 point score differences, P < 0.001), and demonstrated 
      concurrent and construct validity, respectively, through large effect size 
      intercorrelations with the BRIEF (Behavioral Regulation Index, Metacognition 
      Index, Global Executive Composite Summary Scores rs = 0.43-0.67, P < 0.001) and 
      the PedsQL Generic Core Scales (Total Scale Scores rs = 0.67-0.74, P < 0.001). 
      Minimal clinically important difference (MCID) scores ranged from 5.92 to 8.80. 
      CONCLUSIONS: The PedsQL Cognitive Functioning Scale demonstrated excellent 
      internal consistency reliability, discriminant, concurrent, and construct 
      validity in youth with epilepsy and may be suitable as a brief generic 
      patient-reported outcome (PRO) measure for clinical research, clinical trials, 
      and routine clinical practice in pediatric epilepsy.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Varni, James W
AU  - Varni JW
AD  - Department of Pediatrics, College of Medicine, Texas A&M University, College 
      Station, TX, USA; Department of Landscape Architecture and Urban Planning, 
      College of Architecture, Texas A&M University, College Station, TX, USA. 
      Electronic address: jvarni@tamu.edu.
FAU - Junger, Katherine F
AU  - Junger KF
AD  - Department of Pediatrics, Division of Behavioral Medicine and Clinical 
      Psychology, Cincinnati Children's Hospital Medical Center, University of 
      Cincinnati College of Medicine, Cincinnati, OH, USA.
FAU - Kellermann, Tanja
AU  - Kellermann T
AD  - Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, 
      USA.
FAU - Grossman, Lauren Barrett
AU  - Grossman LB
AD  - Division of Pediatric Psychology, Children's Hospital of Orange County, Orange, 
      CA, USA.
FAU - Wagner, Janelle
AU  - Wagner J
AD  - College of Nursing, Medical University of South Carolina, Charleston, SC, USA.
FAU - Mucci, Grace A
AU  - Mucci GA
AD  - Division of Neurology, Children's Hospital of Orange County, Orange, CA, USA.
FAU - Guilfoyle, Shanna M
AU  - Guilfoyle SM
AD  - Department of Pediatrics, Division of Behavioral Medicine and Clinical 
      Psychology, Cincinnati Children's Hospital Medical Center, University of 
      Cincinnati College of Medicine, Cincinnati, OH, USA.
FAU - Smith, Gigi
AU  - Smith G
AD  - College of Nursing, Medical University of South Carolina, Charleston, SC, USA.
FAU - Zupanc, Mary L
AU  - Zupanc ML
AD  - Division of Neurology, Children's Hospital of Orange County, Orange, CA, USA.
FAU - Modi, Avani C
AU  - Modi AC
AD  - Department of Pediatrics, Division of Behavioral Medicine and Clinical 
      Psychology, Cincinnati Children's Hospital Medical Center, University of 
      Cincinnati College of Medicine, Cincinnati, OH, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191230
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cognition/*physiology
MH  - Epilepsy/*diagnosis/*psychology
MH  - Executive Function/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Status and Dementia Tests/*standards
MH  - Parents/psychology
MH  - *Patient Reported Outcome Measures
MH  - Psychometrics
MH  - Quality of Life/*psychology
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Cognitive functioning
OT  - Epilepsy
OT  - Executive functioning
OT  - Patient-reported outcomes
OT  - Pediatrics
OT  - PedsQL
COIS- Declaration of competing interest Dr. Varni holds the copyright and the trademark 
      for the PedsQL and receives financial compensation from the Mapi Research Trust, 
      which is a nonprofit research institute that charges distribution fees to 
      for-profit companies that use the Pediatric Quality of Life Inventory. The other 
      authors report no competing interest related to this study.
EDAT- 2020/01/04 06:00
MHDA- 2020/11/18 06:00
CRDT- 2020/01/04 06:00
PHST- 2019/10/08 00:00 [received]
PHST- 2019/12/06 00:00 [revised]
PHST- 2019/12/07 00:00 [accepted]
PHST- 2020/01/04 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/01/04 06:00 [entrez]
AID - S1525-5050(19)31079-0 [pii]
AID - 10.1016/j.yebeh.2019.106850 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2020 Feb;103(Pt A):106850. doi: 10.1016/j.yebeh.2019.106850. Epub 
      2019 Dec 30.