PMID- 31900022
OWN - NLM
STAT- MEDLINE
DCOM- 20201021
LR  - 20201021
IS  - 1502-4725 (Electronic)
IS  - 0803-9488 (Linking)
VI  - 74
IP  - 5
DP  - 2020 May-Jul
TI  - Homocysteine, chronotype and clinical course in bipolar disorder patients.
PG  - 340-345
LID - 10.1080/08039488.2019.1710250 [doi]
AB  - Purpose: Higher homocysteine (HHcy) levels have been detected in bipolar disorder 
      (BD) patients, and BD patients show circadian rhythm disorders even during 
      remission. Here, we determined the homocysteine (Hcy) levels and chronotype of 
      patients with BD during remission and investigated whether this was related to 
      the clinical course of the disease. Materials and methods: In total, 80 BD 
      outpatients were included. Clinical evaluation was conducted using the Hamilton 
      Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), Pittsburgh Sleep 
      Quality Index (PSQI) and the Morningness-Eveningness Questionnaire (MEQ). Hcy, 
      folic acid, vitamin B12 levels and protein consumption the day before clinical 
      evaluation were measured.Results and conclusions: HHcy was found in 11 patients 
      (8.8%), most of whom were males (n = 8, 72.7%). During the course of BD, patients 
      with HHcy had significantly more mixed episodes than patients without HHcy 
      (p = .007, z = -2696). In addition, patients with HHcy had significantly lower 
      MEQ scores than patients without HHcy (p = .04, t = 2018). There was no 
      significant difference in chronotype between patients with and without HHcy. The 
      HHcy group had significantly lower levels of vitamin B12 (p = .003, t = 2870). 
      There were no statistically significant differences in daily protein intake and 
      folic acid levels between HHcy and non-HHcy groups. Our study showed a 
      significant relationship between the number of mixed episodes and HHcy. In terms 
      of potential confounds, patients who abused alcohol were excluded, but alcohol 
      consumption was not evaluated. This result should be considered in BD and should 
      be evaluated in larger samples of BD patients.
FAU - Ozdogan, Meral Gunes
AU  - Ozdogan MG
AD  - Department of Psychiatry, Ataturk University Medical Faculty, Erzurum, Turkey.
FAU - Aydin, Esat Fahri
AU  - Aydin EF
AD  - Department of Psychiatry, Ataturk University Medical Faculty, Erzurum, Turkey.
FAU - Ustundag, Mehmet Fatih
AU  - Ustundag MF
AD  - Department of Psychiatry, Ataturk University Medical Faculty, Erzurum, Turkey.
FAU - Ceyhun, Hacer Akgul
AU  - Ceyhun HA
AD  - Department of Psychiatry, Ataturk University Medical Faculty, Erzurum, Turkey.
FAU - Oral, Elif
AU  - Oral E
AD  - Department of Psychiatry, Ataturk University Medical Faculty, Erzurum, Turkey.
FAU - Bakan, Ebubekir
AU  - Bakan E
AD  - Department of Medical Biochemistry, Ataturk University Medical Faculty, Erzurum, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200103
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Bipolar Disorder/*blood/*diagnosis/psychology
MH  - Circadian Rhythm/*physiology
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Psychiatric Status Rating Scales/standards
MH  - Retrospective Studies
MH  - Surveys and Questionnaires/standards
MH  - Vitamin B 12/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Bipolar disorder
OT  - chronotype
OT  - clinical course
OT  - homocysteine
EDAT- 2020/01/05 06:00
MHDA- 2020/10/22 06:00
CRDT- 2020/01/05 06:00
PHST- 2020/01/05 06:00 [pubmed]
PHST- 2020/10/22 06:00 [medline]
PHST- 2020/01/05 06:00 [entrez]
AID - 10.1080/08039488.2019.1710250 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2020 May-Jul;74(5):340-345. doi: 
      10.1080/08039488.2019.1710250. Epub 2020 Jan 3.