PMID- 31901598
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 127
DP  - 2020 Mar
TI  - Interactions among thyroid hormone (FT(4)), chemokine (MCP-1) and neurotrophin 
      (NGF-beta) levels studied in Hungarian postmenopausal and obese women.
PG  - 154948
LID - S1043-4666(19)30377-1 [pii]
LID - 10.1016/j.cyto.2019.154948 [doi]
AB  - Thyroid dysfunction is more frequent in postmenopause and metabolic syndrome 
      characterized by increased proinflammatory cytokines (IL-1, IL-6, TNFalpha), insulin 
      resistance and overweight. Serum levels of monocyte chemoattractant protein-1 
      (MCP-1) chemokine and nerve growth factor-beta (NGF-beta) and their effects were 
      studied on thyroid hormone levels in 133 Hungarian women (postmenopausal 66, 
      obese 32, control 35). MCP-1 and NGF-beta levels were measured with enzyme-linked, 
      and thyroid hormones with chemiluminescence immunoassays. Subclinical 
      hypothyroidism in postmenopause (7/66 vs 1/32 cases) and the presence of low 
      FT(4) levels in obese women were more frequent (6/32 vs 2/66 cases, p < 0.0447). 
      Obese women showed reduced serum FT(4) and higher MCP-1 or NGF-beta levels compared 
      to those in postmenopausal women [geometric mean (95%CI): 13.6 (10.9-21.69) vs 
      15.37 (9.06-20.42) pmol/l, p < 0.003 for FT(4), and 19.36 (14.27-26.26) vs 17.29 
      (12.65-23.63) ng/ml, p < 0.0013 for MCP-1 or 18.64 (6.8-51.11) vs 14.01 
      (8.59-22.83) ng/ml, p < 0.0003 for NGF-beta]. Serum FT(4) levels inversely 
      associated with MCP-1 (p < 0.0023, r = -0.1971) or estradiol levels (p < 0.0286, 
      r = -0.1913), and positively associated with age (p < 0.0175, r = 0.2058). As 
      opposed to estradiol and NGF-beta levels, BMI had no effects on serum FT(4) levels 
      in postmenopausal and obese women forming 3 subgroups displaying only MCP-1, both 
      MCP-1 and NGF-beta positivities or no positivities at all. In summary, not only 
      proinflammatory cytokines, but also MCP-1 chemokine and NGF-beta levels can play a 
      role in reduced serum FT(4) levels in postmenopausal and obese women. 
      Particularly, the decreased FT(4) levels were connected to both increased MCP-1 
      and NGF-beta levels in obese women.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Molnar, Ildiko
AU  - Molnar I
AD  - Immunoendocrinology, EndoMed, Bem ter 18/C., Debrecen 4026, Hungary. Electronic 
      address: molil@endomed.hu.
LA  - eng
PT  - Journal Article
DEP - 20191231
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (NGF protein, human)
RN  - 0 (Thyroid Hormones)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Body Mass Index
MH  - Chemokine CCL2/*blood
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Hungary
MH  - Inflammation/blood
MH  - Metabolic Syndrome/blood
MH  - Nerve Growth Factor/*blood
MH  - Obesity/*blood
MH  - Postmenopause/*blood
MH  - Thyroid Gland/metabolism
MH  - Thyroid Hormones/*blood
OTO - NOTNLM
OT  - Free thyroxine levels
OT  - Monocyte chemoattractant protein-1
OT  - Nerve growth factor
OT  - Obesity
OT  - Postmenopause
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/01/07 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/01/06 06:00
PHST- 2019/08/19 00:00 [received]
PHST- 2019/11/23 00:00 [revised]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/01/06 06:00 [entrez]
AID - S1043-4666(19)30377-1 [pii]
AID - 10.1016/j.cyto.2019.154948 [doi]
PST - ppublish
SO  - Cytokine. 2020 Mar;127:154948. doi: 10.1016/j.cyto.2019.154948. Epub 2019 Dec 31.