PMID- 31902363
OWN - NLM
STAT- MEDLINE
DCOM- 20201019
LR  - 20201019
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 16
IP  - 14
DP  - 2019
TI  - The Impact of Angiotensin-Converting Enzyme Gene on Behavioral and Psychological 
      Symptoms of Dementia in Alzheimer's Disease.
PG  - 1269-1275
LID - 10.2174/1567205017666200103114550 [doi]
AB  - BACKGROUND: The Angiotensin-Converting Enzyme (ACE) gene has drawn attention for 
      its possible role in regulating the degradation of beta-amyloid (Abeta), yet its role 
      in affecting the cognitive and psychiatric symptoms of Alzheimer;s Disease (AD) 
      patients has yet to be elucidated. OBJECTIVE: This study aimed to investigate 
      whether the ACE gene acts as a risk factor of Behavioral and Psychological 
      Symptoms of Dementia (BPSD) in the AD population. METHODS: The genotyping of ACE 
      and Apolipoprotein E gene with allele epsilon4(APOEepsilon4) was determined among 360s 
      clinically diagnosed AD patients. Symptoms and severity of BPSD were evaluated 
      annually via Neuropsychiatric Inventory (NPI). RESULTS: At the base measurement 
      of the first year of patient recruitment, there were no significant contributory 
      risk factors to NPI score. In the two-year follow-up, ACE insertion polymorphism 
      showed a significant risk (adjusted odds ratio=1.65, 95% CI=1.1- 2.5, p=0.019) of 
      progression of NPI total score. CONCLUSION: ACE gene is involved in aggravating 
      BPSD among AD patients.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Hsieh, Sun-Wung
AU  - Hsieh SW
AD  - Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
AD  - Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Liu, Ming-Wei
AU  - Liu MW
AD  - Department of Surgery, Cathay General Hospital, Taipei, Taiwan.
FAU - Huang, Ling-Chun
AU  - Huang LC
AD  - Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
AD  - Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Wu, Meng-Ni
AU  - Wu MN
AD  - Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Yang, Yuan-Han
AU  - Yang YH
AD  - Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
AD  - Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
AD  - Department of and Master's Program in Neurology, Faculty of Medicine, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
AD  - Chinese Mentality Protection Association, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - EC 3.4.15.1 (ACE protein, human)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/complications/*genetics
MH  - Behavioral Symptoms/*genetics
MH  - Dementia/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Peptidyl-Dipeptidase A/*genetics
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - angiotensin-converting enzyme gene
OT  - apolipoprotein E gene
OT  - behavioral and psychological symptoms of dementia
OT  - neuropsychiatric inventory
OT  - beta-amyloid.
EDAT- 2020/01/07 06:00
MHDA- 2020/10/21 06:00
CRDT- 2020/01/07 06:00
PHST- 2019/04/01 00:00 [received]
PHST- 2019/12/12 00:00 [revised]
PHST- 2019/12/30 00:00 [accepted]
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/01/07 06:00 [entrez]
AID - CAR-EPUB-103451 [pii]
AID - 10.2174/1567205017666200103114550 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2019;16(14):1269-1275. doi: 
      10.2174/1567205017666200103114550.