PMID- 31902370 OWN - NLM STAT- MEDLINE DCOM- 20200907 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 22 IP - 1 DP - 2020 Jan 6 TI - Left ventricular function recovery in peripartum cardiomyopathy: a cardiovascular magnetic resonance study by myocardial T1 and T2 mapping. PG - 2 LID - 10.1186/s12968-019-0590-z [doi] LID - 2 AB - BACKGROUND: Peripartum cardiomyopathy (PPCM) is rare and potentially life-threatening; its etiology remains unclear. Imaging characteristics on cardiovascular magnetic resonance (CMR) and their prognostic significance have rarely been studied. We sought to determine CMR's prognostic value in PPCM by using T1 and T2 mapping techniques. METHODS: Data from 21 PPCM patients from our CMR registry database were analyzed. The control group comprised 20 healthy age-matched females. All subjects underwent comprehensive contrast-enhanced CMR. T1 and T2 mapping using modified Look-Locker inversion recovery and T2 prep balanced steady-state free precession sequences, respectively. Ventricular size and function, late gadolinium enhancement (LGE), myocardial T1 value, extracellular volume (ECV), and T2 value were analyzed. Transthoracic echocardiography was performed at baseline and during follow-up. The recovered left ventricular ejection fraction (LVEF) was defined as LVEF >/=50% on echocardiography follow-up after at least 6 months of the diagnosis. RESULTS: CMR imaging showed that the PPCM patients had severely impaired LVEF and right ventricular ejection fraction (LVEF: 26.8 +/- 10.6%; RVEF: 33.9 +/- 14.6%). LGE was seen in eight (38.1%) cases. PPCM patients had significantly higher native T1 and ECV (1345 +/- 79 vs. 1212 +/- 32 ms, P < 0.001; 33.9 +/- 5.2% vs. 27.1 +/- 3.1%, P < 0.001; respectively) and higher myocardial T2 value (42.3 +/- 3.7 vs. 36.8 +/- 2.3 ms, P < 0.001) than did the normal controls. After a median 2.5-year follow-up (range: 8 months-5 years), six patients required readmission for heart failure, two died, and 10 showed left ventricular function recovery. The LVEF-recovered group showed significantly lower ECV (30.7 +/- 2.1% vs. 36.8 +/- 5.6%, P = 0.005) and T2 (40.6 +/- 3.0 vs. 43.9 +/- 3.7 ms, P = 0.040) than the unrecovered group. Multivariable logistic regression analysis showed ECV (OR = 0.58 for per 1% increase, P = 0.032) was independently associated with left ventricular recovery in PPCM. CONCLUSIONS: Compared to normal controls, PPCM patients showed significantly higher native T1, ECV, and T2. Native T1, ECV, and T2 were associated with LVEF recovery in PPCM. Furthermore, ECV could independently predict left ventricular function recovery in PPCM. FAU - Liang, Yao-Dan AU - Liang YD AD - Department of Cardiology, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China. AD - Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, China. AD - Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Xu, Yuan-Wei AU - Xu YW AD - Department of Cardiology, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China. FAU - Li, Wei-Hao AU - Li WH AD - Department of Cardiology, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China. FAU - Wan, Ke AU - Wan K AD - Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Sun, Jia-Yu AU - Sun JY AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Lin, Jia-Yi AU - Lin JY AD - Department of Cardiology, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China. FAU - Zhang, Qing AU - Zhang Q AD - Department of Cardiology, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China. FAU - Zhou, Xiao-Yue AU - Zhou XY AD - MR Collaboration, Siemens Healthineers Ltd., Shanghai, China. FAU - Chen, Yu-Cheng AU - Chen YC AUID- ORCID: 0000-0002-1771-4769 AD - Department of Cardiology, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China. chenyucheng2003@126.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200106 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 SB - IM MH - Adult MH - Cardiomyopathies/*diagnostic imaging/etiology/physiopathology MH - Case-Control Studies MH - Databases, Factual MH - Female MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Observer Variation MH - Peripartum Period MH - Predictive Value of Tests MH - Pregnancy MH - Pregnancy Complications, Cardiovascular/*diagnostic imaging/etiology/physiopathology MH - Recovery of Function MH - Reproducibility of Results MH - Risk Factors MH - *Stroke Volume MH - Time Factors MH - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology MH - *Ventricular Function, Left MH - Young Adult PMC - PMC6943890 OTO - NOTNLM OT - Cardiovascular magnetic resonance OT - Extracellular volume OT - Left ventricular function recovery OT - Peripartum cardiomyopathy OT - T1 mapping OT - T2 mapping COIS- The authors declare that they have no competing interests. EDAT- 2020/01/07 06:00 MHDA- 2020/09/08 06:00 PMCR- 2020/01/06 CRDT- 2020/01/07 06:00 PHST- 2019/08/01 00:00 [received] PHST- 2019/12/05 00:00 [accepted] PHST- 2020/01/07 06:00 [entrez] PHST- 2020/01/07 06:00 [pubmed] PHST- 2020/09/08 06:00 [medline] PHST- 2020/01/06 00:00 [pmc-release] AID - S1097-6647(23)00254-5 [pii] AID - 590 [pii] AID - 10.1186/s12968-019-0590-z [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2020 Jan 6;22(1):2. doi: 10.1186/s12968-019-0590-z.