PMID- 31902391
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Print)
IS  - 0924-2708 (Linking)
VI  - 32
IP  - 3
DP  - 2020 Jan 6
TI  - Prenatal alcohol exposure is associated with early motor, but not language 
      development in a South African cohort.
PG  - 1-8
LID - 10.1017/neu.2019.51 [doi]
AB  - OBJECTIVE: To investigate the association of prenatal alcohol exposure (PAE) and 
      early neurodevelopment in the first 2 years of life, adjusting for maternal 
      socio-demographic and psychosocial factors, in the Drakenstein Child Health Study 
      (DCHS), a South African birth cohort study. METHODS: The DCHS comprises a 
      population-based birth cohort of 1143 children, of which a subsample completed 
      the Bayley Scales of Infant Development-III (BSID-III) at 6 (n = 260) and 24 
      months of age (n = 734). A subset of alcohol-exposed and -unexposed children was 
      included in this analysis at age 6 (n = 52 exposed; n = 104 unexposed) and 24 
      months (n = 92 exposed; n = 184 unexposed). Multiple hierarchical regression was 
      used to explore the associations of PAE with motor and language development. 
      RESULTS: PAE was significantly associated with decreased gross motor [odds ratio 
      (OR) = 0.16, 95% confidence interval (CI) = 0.06-0.44, p = 0.001] or fine motor 
      (OR = 0.16, 95% CI = 0.06-0.46, p = 0.001) functioning after adjusting for 
      maternal socio-demographic and psychosocial factors at 6 months of age only. No 
      significant effects were found in either receptive or expressive communication 
      and cognitive outcomes at either time points. CONCLUSION: PAE has potentially 
      important consequences for motor development in the first 2 years of life, a 
      period during which the most rapid growth and maturation occur. These findings 
      highlight the importance of identifying high-risk families in order to provide 
      preventive interventions, particularly in antenatal clinics and early 
      intervention services.
FAU - Hendricks, Gaironeesa
AU  - Hendricks G
AUID- ORCID: 0000-0002-9791-3652
AD  - Department of Psychiatry and Mental Health, and SAMRC Unit on Risk and 
      Resilience, University of Cape Town, Cape Town, South Africa.
AD  - Department of Paediatrics and Child Health, Red Cross War Memorial Children's 
      Hospital, University of Cape Town, Cape Town, South Africa.
FAU - Malcolm-Smith, Susan
AU  - Malcolm-Smith S
AD  - Department of Psychology, Applied Cognitive Science and Experimental 
      Neuropsychology Team, University of Cape Town, Cape Town, South Africa.
FAU - Stein, Dan J
AU  - Stein DJ
AD  - Department of Psychiatry and Mental Health, and SAMRC Unit on Risk and 
      Resilience, University of Cape Town, Cape Town, South Africa.
AD  - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, 
      South Africa.
FAU - Zar, Heather J
AU  - Zar HJ
AD  - Department of Paediatrics and Child Health, Red Cross War Memorial Children's 
      Hospital, University of Cape Town, Cape Town, South Africa.
AD  - SAMRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, 
      South Africa.
FAU - Wedderburn, Catherine J
AU  - Wedderburn CJ
AD  - Department of Paediatrics and Child Health, Red Cross War Memorial Children's 
      Hospital, University of Cape Town, Cape Town, South Africa.
AD  - Department of Clinical Research, London School of Hygiene & Tropical Medicine, 
      London, UK.
FAU - Nhapi, Raymond T
AU  - Nhapi RT
AD  - Department of Paediatrics and Child Health, Red Cross War Memorial Children's 
      Hospital, University of Cape Town, Cape Town, South Africa.
FAU - Chivese, Tawanda
AU  - Chivese T
AD  - Department of Population Health, College of Medicine, Qatar University, Doha, 
      Qatar.
FAU - Adnams, Colleen M
AU  - Adnams CM
AD  - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, 
      South Africa.
FAU - Donald, Kirsten A
AU  - Donald KA
AD  - Department of Paediatrics and Child Health, Red Cross War Memorial Children's 
      Hospital, University of Cape Town, Cape Town, South Africa.
AD  - Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
LA  - eng
GR  - R01 AA026834/AA/NIAAA NIH HHS/United States
GR  - R21 AA023887/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20200106
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
SB  - IM
PMC - PMC7282868
MID - NIHMS1570929
OTO - NOTNLM
OT  - language development
OT  - motor development
OT  - neurodevelopment
OT  - prenatal alcohol exposure
EDAT- 2020/01/07 06:00
MHDA- 2020/01/07 06:00
PMCR- 2020/06/09
CRDT- 2020/01/07 06:00
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2020/01/07 06:00 [entrez]
PHST- 2020/06/09 00:00 [pmc-release]
AID - S0924270819000516 [pii]
AID - 10.1017/neu.2019.51 [doi]
PST - aheadofprint
SO  - Acta Neuropsychiatr. 2020 Jan 6;32(3):1-8. doi: 10.1017/neu.2019.51.