PMID- 31902927
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20201109
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 43
IP  - 1
DP  - 2020
TI  - Multiple Biological Aspects of Eosinophils in Host Defense, Eosinophil-Associated 
      Diseases, Immunoregulation, and Homeostasis: Is Their Role Beneficial, 
      Detrimental, Regulator, or Bystander?
PG  - 20-30
LID - 10.1248/bpb.b19-00892 [doi]
AB  - Eosinophils are innate immune leukocytes and play important roles as terminal 
      effector cells owing to their mediators, such as tissue-destructive cationic 
      proteins, cytokines, chemokines, and lipid mediators. Historically, they are not 
      only considered an important player in host defense against parasitic, viral, 
      fungal, and bacterial infections but also implicated in the pathogenesis of 
      eosinophil-associated diseases, such as allergic rhinitis, asthma, eosinophilic 
      chronic rhinosinusitis, esophagitis, atopic dermatitis, myopathies, and 
      hypereosinophilic syndrome. Moreover, recent studies have shown that eosinophils 
      have an immune regulatory and homeostatic function. Interestingly, there is 
      emerging evidence that eosinophils are accumulated through adoptive T-helper 2 
      (Th2) and innate Th2 responses, mechanisms of the classical allergen-specific 
      immunoglobulin E (IgE)-mediated response, and group 2 innate lymphoid 
      cell-derived interleukin-5, respectively. Furthermore, in agreement with current 
      concepts of eosinophil subtypes, it has been shown that resident and 
      phenotypically distinct eosinophils, i.e., resident and recruited inflammatory 
      eosinophils, exist in inflamed sites, and each has different functions. Thus, the 
      classical and novel studies suggest that eosinophils have multiple functions, and 
      their roles may be altered by the environment. In this article, we review 
      multiple biological aspects of eosinophils (novel and classical roles), including 
      their beneficial and detrimental effects, immunoregulation, and homeostatic 
      function.
FAU - Kanda, Akira
AU  - Kanda A
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
AD  - Allergy Center, Kansai Medical University.
FAU - Yasutaka, Yun
AU  - Yasutaka Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
FAU - Van Bui, Dan
AU  - Van Bui D
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
FAU - Suzuki, Kensuke
AU  - Suzuki K
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
FAU - Sawada, Shunsuke
AU  - Sawada S
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
FAU - Kobayashi, Yoshiki
AU  - Kobayashi Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
AD  - Allergy Center, Kansai Medical University.
FAU - Asako, Mikiya
AU  - Asako M
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
AD  - Allergy Center, Kansai Medical University.
FAU - Iwai, Hiroshi
AU  - Iwai H
AD  - Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
SB  - IM
MH  - Animals
MH  - Eosinophils/*immunology
MH  - Homeostasis
MH  - Humans
MH  - Immunomodulation
MH  - Infections/immunology
MH  - Inflammation/immunology
OTO - NOTNLM
OT  - allergic rhinitis (AR)
OT  - asthma
OT  - eosinophil
OT  - eosinophilic chronic rhinosinusitis (ECRS)
EDAT- 2020/01/07 06:00
MHDA- 2020/11/11 06:00
CRDT- 2020/01/07 06:00
PHST- 2020/01/07 06:00 [entrez]
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
AID - 10.1248/bpb.b19-00892 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2020;43(1):20-30. doi: 10.1248/bpb.b19-00892.