PMID- 31903180 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2042-0188 (Print) IS - 2042-0196 (Electronic) IS - 2042-0188 (Linking) VI - 10 DP - 2019 TI - Association between air pollution and type 2 diabetes: an updated review of the literature. PG - 2042018819897046 LID - 10.1177/2042018819897046 [doi] LID - 2042018819897046 AB - Air pollution and type 2 diabetes mellitus (T2DM) are critical public health issues worldwide. A large number of epidemiological studies have highlighted the adverse effects of air pollution on diabetes, and include risk profiles for different exposure durations, study design types, subgroup populations, and effects of air pollution components. We researched PubMed, Google Scholar, and Web of Science to identify studies on the association between air pollution and T2DM from January 2009 to January 2019. The aim of this review is to provide a brief overview of epidemiological and experimental studies on air pollution associated with T2DM from the latest research, which may provide practical information about this relationship and possible mechanisms. Current cumulative evidence appears to suggest that T2DM-related biomarkers increase with increasing exposure duration and concentration of air pollutants. The chemical constituents of the air pollutant mixture may affect T2DM to varying degrees. The suggested mechanisms whereby air pollutants induce T2DM include increased inflammation, oxidative stress, and endoplasmic reticulum stress. CI - (c) The Author(s), 2019. FAU - Li, Yongze AU - Li Y AD - Department of Endocrinology and Metabolism, Key Laboratory of Thyroid Disease in Liaoning Provinces, The First Hospital of China Medical University, Shenyang, China. FAU - Xu, Lu AU - Xu L AD - Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China. FAU - Shan, Zhongyan AU - Shan Z AD - Department of Endocrinology and Metabolism, Key Laboratory of Thyroid Disease in Liaoning Provinces, The First Hospital of China Medical University, Shenyang, China. FAU - Teng, Weiping AU - Teng W AD - Department of Endocrinology and Metabolism, Key Laboratory of Thyroid Disease in Liaoning Province, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, PRC. FAU - Han, Cheng AU - Han C AUID- ORCID: 0000-0001-8782-3314 AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer 216, the Bronx, New York, NY, 10461, USA. LA - eng PT - Journal Article PT - Review DEP - 20191224 PL - United States TA - Ther Adv Endocrinol Metab JT - Therapeutic advances in endocrinology and metabolism JID - 101532143 PMC - PMC6931138 OTO - NOTNLM OT - air pollution OT - fine particulate matter OT - insulin resistance OT - type 2 diabetes mellitus COIS- Conflict of interest statement: The authors declare that there is no conflict of interest. EDAT- 2020/01/07 06:00 MHDA- 2020/01/07 06:01 PMCR- 2019/12/24 CRDT- 2020/01/07 06:00 PHST- 2018/11/13 00:00 [received] PHST- 2019/12/02 00:00 [accepted] PHST- 2020/01/07 06:00 [entrez] PHST- 2020/01/07 06:00 [pubmed] PHST- 2020/01/07 06:01 [medline] PHST- 2019/12/24 00:00 [pmc-release] AID - 10.1177_2042018819897046 [pii] AID - 10.1177/2042018819897046 [doi] PST - epublish SO - Ther Adv Endocrinol Metab. 2019 Dec 24;10:2042018819897046. doi: 10.1177/2042018819897046. eCollection 2019.