PMID- 3190366
OWN - NLM
STAT- MEDLINE
DCOM- 19881221
LR  - 20061115
IS  - 0020-3785 (Print)
VI  - 58
IP  - 4
DP  - 1988 Jul-Aug
TI  - [Importance of the early intravenous administration of streptokinase in acute 
      myocardial infarct].
PG  - 307-11
AB  - To evaluate the importance of early initiation of fibrinolytic therapy with 
      intravenous streptokinase (IVSK), we studied 34 consecutive patients, within less 
      than six hours of the onset of acute myocardial infarction, who were treated with 
      1.5 million units of intravenous streptokinase. All the patients had coronary 
      angiograms in the first seventy two hours. We correlated the angiograms with the 
      time of onset of the IVSK. The patients were divided into 3 groups: Group num. 1: 
      From zero to two hours (twelve patients); Group num. 2: From two to four hours 
      (13 patients); and Group num. 3: From four to six hours (nine patients). We had 
      angiographic reperfusion in twenty-four patients (70.2%) P less than 0.05. We 
      observed reopening in the patients of group num. 1 (83.3%); in group 2, nine 
      patients (69%) and in group num. 3, five patients, (55.5%), with statistical 
      significance only in group num. 1 (p less than 0.05). We also demonstrated the 
      utility of the electrocardiographic and enzymatic criteria to predict 
      reperfusion. No mortality was related to the procedure. We concluded that a 
      higher percentage of reperfusion is obtained the sooner intravenous streptokinase 
      therapy is initiated.
FAU - Martinez Rios, M A
AU  - Martinez Rios MA
AD  - Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico, D.F.
FAU - Levy, J
AU  - Levy J
FAU - Gil Moreno, M
AU  - Gil Moreno M
FAU - Ojeda, J L
AU  - Ojeda JL
FAU - Garcia, P
AU  - Garcia P
FAU - Cardenas, M
AU  - Cardenas M
FAU - Soni, J
AU  - Soni J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Importancia del inicio precoz en la administracion de estreptoquinasa intravenosa 
      en el infarto agudo del miocardio.
PL  - Mexico
TA  - Arch Inst Cardiol Mex
JT  - Archivos del Instituto de Cardiologia de Mexico
JID - 0400463
RN  - EC 3.4.- (Streptokinase)
SB  - IM
MH  - Coronary Circulation/*drug effects
MH  - Humans
MH  - Injections, Intravenous
MH  - Myocardial Infarction/*drug therapy/physiopathology
MH  - Streptokinase/administration & dosage/pharmacology/*therapeutic use
MH  - Time Factors
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
PST - ppublish
SO  - Arch Inst Cardiol Mex. 1988 Jul-Aug;58(4):307-11.