PMID- 31904030
OWN - NLM
STAT- MEDLINE
DCOM- 20200904
LR  - 20200904
IS  - 0300-0729 (Print)
IS  - 0300-0729 (Linking)
VI  - 58
IP  - 2
DP  - 2020 Apr 1
TI  - Local fungus-specific Immunoglobulin E production in chronic rhinosinusitis with 
      nasal polyps.
PG  - 136-144
LID - 10.4193/Rhin18.225 [doi]
AB  - BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous 
      disease, and its pathogenesis remains controversial. This study aimed to examine 
      the involvement of fungi in CRSwNP pathogenesis. METHODS: We enrolled 29 controls 
      and 111 CRSwNP patients. We analyzed fungi in the nasal secretions, serum 
      fungus-specific immunoglobulin E (IgE) levels, and nasal polyp (NP) IgE levels. 
      Moreover, we evaluated the correlation between patients' IgE levels and computed 
      tomography (CT) scores. RESULTS: There was no difference in fungal detection rate 
      between CRSwNP patients with and without asthma. Specific IgEs against various 
      antigens were highly detectable in NPs of CRSwNP patients. In CRSwNP patients, 
      fungus-specific IgE levels in NPs were correlated with CT scores. Serum 
      fungus-specific IgEs became undetectable after operation in more than half of the 
      CRSwNP patients without asthma but not in those with asthma. Other serum airborne 
      antigen-specific IgEs did not become undetectable after operation. CONCLUSIONS: 
      Fungus-specific IgEs were highly detectable in NPs of CRSwNP patients, and NPs 
      comprised a major region of specific IgE production. Fungi may therefore play an 
      important role in CRSwNP pathogenesis by inducing Th2 immune responses, including 
      IgE synthesis.
FAU - Ohki, Y
AU  - Ohki Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate 
      School of Medicine, Chiba, Japan.
FAU - Okamoto, Y
AU  - Okamoto Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate 
      School of Medicine, Chiba, Japan.
FAU - Iinuma, T
AU  - Iinuma T
AD  - Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate 
      School of Medicine, Chiba, Japan.
FAU - Yamamoto, H
AU  - Yamamoto H
AD  - Division of Otolaryngology, Kimitsu Central Hospital, Kimitsu, Japan.
FAU - Toyotome, T
AU  - Toyotome T
AD  - Diagnostic Center for Animal Health and Food Safety, Obihiro University of 
      Agriculture and Veterinary Medicine, Obihiro, Japan.
FAU - Yahiro, M
AU  - Yahiro M
AD  - Division of Clinical Research, Medical Mycology Research Center, Chiba 
      University, Chiba, Japan.
FAU - Yonekura, S
AU  - Yonekura S
AD  - Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate 
      School of Medicine, Chiba, Japan.
FAU - Sakurai, D
AU  - Sakurai D
AD  - Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate 
      School of Medicine, Chiba, Japan.
FAU - Kamei, K
AU  - Kamei K
AD  - Division of Clinical Research, Medical Mycology Research Center, Chiba 
      University, Chiba, Japan.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Rhinology
JT  - Rhinology
JID - 0347242
RN  - 0 (Antibodies, Fungal)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Fungal/*immunology
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Fungi
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Mycoses/complications/*immunology
MH  - Nasal Polyps/*immunology/microbiology
MH  - Rhinitis/*immunology/microbiology
MH  - Sinusitis/*immunology/microbiology
EDAT- 2020/01/07 06:00
MHDA- 2020/09/05 06:00
CRDT- 2020/01/07 06:00
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2020/09/05 06:00 [medline]
PHST- 2020/01/07 06:00 [entrez]
AID - 2229 [pii]
AID - 10.4193/Rhin18.225 [doi]
PST - ppublish
SO  - Rhinology. 2020 Apr 1;58(2):136-144. doi: 10.4193/Rhin18.225.