PMID- 31904461
OWN - NLM
STAT- MEDLINE
DCOM- 20201119
LR  - 20201119
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 146
DP  - 2020 Mar 1
TI  - Chitosan functionalized magnetic graphene oxide nanocomposite for the sensitive 
      and effective determination of alkaloids in hotpot.
PG  - 343-352
LID - S0141-8130(19)40273-0 [pii]
LID - 10.1016/j.ijbiomac.2019.12.259 [doi]
AB  - Chitosan functionalized magnetic graphene oxide nanocomposite 
      (Fe(3)O(4)@SiO(2)@CS/GO) was successfully fabricated via a facile amide reaction 
      between chitosan and graphene oxide. A novel extraction method using 
      Fe(3)O(4)@SiO(2)@CS/GO as nanoadsorbent was developed and applied to the 
      efficient extraction and determination of multiple alkaloids from the complex 
      matrix. The composition and structure of the nanoadsorbent was systematically 
      characterized by various techniques. The nanoadsorbent possesses performances of 
      high efficiency, easy operation, superparamagnetism, environment friendly and 
      economic feasibility. The adsorption mechanism for alkaloids included pi-pi 
      electron-donor-acceptor interaction, cation-pi interaction and hydrogen bonding. 
      The principal parameters influencing extraction procedure such as adsorbent 
      dosage, pH, adsorption time, desorption conditions and regeneration cycles were 
      investigated and optimized. Under the optimized conditions, the method exhibited 
      good linear dynamic range with correlation coefficient (r(2)) higher than 0.997 
      and the limit of detection (LOD) was among 0.016--0.092 mug kg(-)(1). Intra- and 
      inter-day relative standard deviations (RSDs) were <10%. These results indicated 
      that the developed method was successfully applied for simultaneous detection of 
      alkaloids in hotpot. This study provided valuable guidance and effective method 
      for the analysis of alkaloids in intricate interference system.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Tang, Tiantian
AU  - Tang T
AD  - College of Pharmacy, Chongqing Medical University, Chongqing 400016, China. 
      Electronic address: 952876329@qq.com.
FAU - Cao, Shurui
AU  - Cao S
AD  - Forensic Identification Center, Southwest University of Political Science and 
      Law, Chongqing 401120, China. Electronic address: caoshurui@yeah.net.
FAU - Xi, Cunxian
AU  - Xi C
AD  - The Inspection Technical Center of Chongqing Customs, Chongqing 400020, China. 
      Electronic address: cqxicx@163.com.
FAU - Li, Xianliang
AU  - Li X
AD  - The Inspection Technical Center of Chongqing Customs, Chongqing 400020, China. 
      Electronic address: cqciqlxl@163.com.
FAU - Zhang, Lei
AU  - Zhang L
AD  - The Inspection Technical Center of Chongqing Customs, Chongqing 400020, China. 
      Electronic address: zhangleihaoy@163.com.
FAU - Wang, Guomin
AU  - Wang G
AD  - The Inspection Technical Center of Chongqing Customs, Chongqing 400020, China. 
      Electronic address: chqwgm@163.com.
FAU - Chen, Zhiqiong
AU  - Chen Z
AD  - College of Pharmacy, Chongqing Medical University, Chongqing 400016, China. 
      Electronic address: chenzq@cqmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200102
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Alkaloids)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Alkaloids/*analysis
MH  - Chitosan/*chemistry
MH  - Graphite/*chemistry
MH  - Magnetite Nanoparticles/*chemistry
MH  - Nanocomposites/*chemistry
OTO - NOTNLM
OT  - Alkaloids
OT  - Chitosan
OT  - Graphene oxide
OT  - Magnetic solid phase extraction
COIS- Declaration of competing interest The authors declare that there is no conflict 
      of interest.
EDAT- 2020/01/07 06:00
MHDA- 2020/11/20 06:00
CRDT- 2020/01/07 06:00
PHST- 2019/12/13 00:00 [received]
PHST- 2019/12/27 00:00 [revised]
PHST- 2019/12/30 00:00 [accepted]
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2020/01/07 06:00 [entrez]
AID - S0141-8130(19)40273-0 [pii]
AID - 10.1016/j.ijbiomac.2019.12.259 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Mar 1;146:343-352. doi: 10.1016/j.ijbiomac.2019.12.259. 
      Epub 2020 Jan 2.