PMID- 31905014
OWN - NLM
STAT- MEDLINE
DCOM- 20200319
LR  - 20221213
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 39
IP  - 3
DP  - 2020 Mar
TI  - Investigation of Oxidative Stress-Related Candidate Genes as Risk Factors for 
      Drug-Induced Liver Injury due to Co-Amoxiclav.
PG  - 349-354
LID - 10.1089/dna.2019.4982 [doi]
AB  - The liver is susceptible to drug toxicity due to its vital role in xenobiotic 
      metabolism and elimination. In addition to human leukocyte antigen (HLA) 
      variants, which were previously determined as risk factors for drug-induced liver 
      injury (DILI) due to co-amoxiclav, other non-HLA genes may contribute to 
      hepatotoxicity risk. In this study, the association between DILI due to 
      co-amoxiclav and several non-HLA genes was investigated. Association of variants 
      in candidate genes (SOD2, GPX1, GSTM1, and GSTT1) with DILI due to various drugs 
      was reported previously in other DILI cohorts. This study examined relevance in a 
      co-amoxiclav-DILI cohort. One hundred sixty-five co-amoxiclav DILI cases were 
      recruited from several European countries by two different studies (DILIGEN and 
      iDILIC). A North-East England population group (n = 334) was used as the control 
      group. PCR assays were used to genotype for the GSTM1 and GSTT1 null alleles with 
      TaqMan SNP genotyping assays used for SOD2 (rs4880) and GPX1 (rs1050450). 
      Fisher's exact test was used to assess differences in significance between cases 
      and controls. None of the studied variants (SOD2 rs4880, GPX1 rs1050450, GSTM1 
      null allele, and GSTT1 null allele) was significantly associated with 
      co-amoxiclav DILI compared with the control group. No significant differences 
      between cases and controls were seen when combined SOD2/GPX1 genotypes and GST 
      genotypes were considered. Despite the possible functional relevance and the 
      previously reported contribution of the selected genes to DILI, our study failed 
      to confirm associations between the selected genes and liver injury induced by 
      co-amoxiclav.
FAU - Alshabeeb, Mohammad A
AU  - Alshabeeb MA
AD  - Translational and Clinical Research Institute, Faculty of Medical Sciences, 
      Newcastle University, Newcastle upon Tyne, United Kingdom.
AD  - Department of Developmental Medicine, King Abdullah International Medical 
      Research Center (KAIMRC), Riyadh, Saudi Arabia.
AD  - King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
FAU - Aithal, Guruprasad P
AU  - Aithal GP
AD  - NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS 
      Trust, University of Nottingham, Nottingham, United Kingdom.
AD  - Nottingham Digestive Diseases Centre, School of Medicine, University of 
      Nottingham, Nottingham, United Kingdom.
FAU - Daly, Ann K
AU  - Daly AK
AD  - Translational and Clinical Research Institute, Faculty of Medical Sciences, 
      Newcastle University, Newcastle upon Tyne, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20200106
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (Anti-Bacterial Agents)
RN  - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (superoxide dismutase 2)
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
RN  - EC 1.11.1.9 (Glutathione Peroxidase GPX1)
RN  - EC 1.11.1.9 (GPX1 protein, human)
SB  - IM
MH  - Aged
MH  - Amoxicillin-Potassium Clavulanate Combination/toxicity
MH  - Anti-Bacterial Agents/toxicity
MH  - Chemical and Drug Induced Liver Injury/etiology/*genetics
MH  - Female
MH  - Glutathione Peroxidase/genetics
MH  - Glutathione Transferase/genetics
MH  - Humans
MH  - Loss of Function Mutation
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - *Polymorphism, Single Nucleotide
MH  - Superoxide Dismutase/genetics
MH  - Glutathione Peroxidase GPX1
OTO - NOTNLM
OT  - GPX1
OT  - GSTM1
OT  - GSTT1
OT  - SOD2
OT  - amoxicillin-clavulanic acid
OT  - co-amoxiclav
OT  - drug-induced liver injury (DILI)
OT  - oxidative stress genes
EDAT- 2020/01/07 06:00
MHDA- 2020/03/20 06:00
CRDT- 2020/01/07 06:00
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2020/03/20 06:00 [medline]
PHST- 2020/01/07 06:00 [entrez]
AID - 10.1089/dna.2019.4982 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2020 Mar;39(3):349-354. doi: 10.1089/dna.2019.4982. Epub 2020 Jan 
      6.