PMID- 31905199
OWN - NLM
STAT- MEDLINE
DCOM- 20200424
LR  - 20200424
IS  - 1545-7885 (Electronic)
IS  - 1544-9173 (Print)
IS  - 1544-9173 (Linking)
VI  - 18
IP  - 1
DP  - 2020 Jan
TI  - Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative 
      neurogenesis in Alzheimer's model of adult zebrafish brain.
PG  - e3000585
LID - 10.1371/journal.pbio.3000585 [doi]
LID - e3000585
AB  - It was recently suggested that supplying the brain with new neurons could 
      counteract Alzheimer's disease (AD). This provocative idea requires further 
      testing in experimental models in which the molecular basis of disease-induced 
      neuronal regeneration could be investigated. We previously found that zebrafish 
      stimulates neural stem cell (NSC) plasticity and neurogenesis in AD and could 
      help to understand the mechanisms to be harnessed for developing new neurons in 
      diseased mammalian brains. Here, by performing single-cell transcriptomics, we 
      found that amyloid toxicity-induced interleukin-4 (IL4) promotes NSC 
      proliferation and neurogenesis by suppressing the tryptophan metabolism and 
      reducing the production of serotonin. NSC proliferation was suppressed by 
      serotonin via down-regulation of brain-derived neurotrophic factor 
      (BDNF)-expression in serotonin-responsive periventricular neurons. BDNF enhances 
      NSC plasticity and neurogenesis via nerve growth factor receptor A (NGFRA)/ 
      nuclear factor 'kappa-light-chain-enhancer' of activated B-cells (NFkB) signaling 
      in zebrafish but not in rodents. Collectively, our results suggest a complex 
      neuron-glia interaction that regulates regenerative neurogenesis after AD 
      conditions in zebrafish.
FAU - Bhattarai, Prabesh
AU  - Bhattarai P
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
FAU - Cosacak, Mehmet Ilyas
AU  - Cosacak MI
AUID- ORCID: 0000-0003-2978-3902
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
FAU - Mashkaryan, Violeta
AU  - Mashkaryan V
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
FAU - Demir, Sevgican
AU  - Demir S
AUID- ORCID: 0000-0001-8610-1192
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
FAU - Popova, Stanislava Dimitrova
AU  - Popova SD
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
AD  - CRTD-Center for Regenerative Therapies Technische Universitat Dresden, Dresden, 
      Germany.
FAU - Govindarajan, Nambirajan
AU  - Govindarajan N
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
FAU - Brandt, Kerstin
AU  - Brandt K
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
FAU - Zhang, Yixin
AU  - Zhang Y
AD  - B CUBE, Center for Molecular Bioengineering, Technische Universitat Dresden, 
      Dresden, Germany.
FAU - Chang, Weipang
AU  - Chang W
AD  - Karolinska Institutet, Neuroscience Department, Stockholm, Sweden.
FAU - Ampatzis, Konstantinos
AU  - Ampatzis K
AUID- ORCID: 0000-0001-7998-6463
AD  - Karolinska Institutet, Neuroscience Department, Stockholm, Sweden.
FAU - Kizil, Caghan
AU  - Kizil C
AUID- ORCID: 0000-0002-8164-9762
AD  - German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, 
      Dresden, Germany.
AD  - CRTD-Center for Regenerative Therapies Technische Universitat Dresden, Dresden, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200106
PL  - United States
TA  - PLoS Biol
JT  - PLoS biology
JID - 101183755
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Zebrafish Proteins)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Age Factors
MH  - *Alzheimer Disease/genetics/pathology/physiopathology
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Brain/metabolism/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cell Communication/*physiology
MH  - Disease Models, Animal
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Regeneration/genetics/*physiology
MH  - Neural Stem Cells/pathology/physiology
MH  - Neurogenesis/*physiology
MH  - Neuroglia/*physiology
MH  - Neuroimmunomodulation/physiology
MH  - Neuronal Plasticity/physiology
MH  - Neurons/*physiology
MH  - Receptors, Nerve Growth Factor/genetics/metabolism
MH  - Serotonin/genetics/metabolism
MH  - Signal Transduction/genetics
MH  - Zebrafish
MH  - Zebrafish Proteins/genetics/metabolism
PMC - PMC6964913
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/01/07 06:00
MHDA- 2020/04/25 06:00
PMCR- 2020/01/06
CRDT- 2020/01/07 06:00
PHST- 2019/08/26 00:00 [received]
PHST- 2019/12/12 00:00 [accepted]
PHST- 2020/01/16 00:00 [revised]
PHST- 2020/01/07 06:00 [pubmed]
PHST- 2020/04/25 06:00 [medline]
PHST- 2020/01/07 06:00 [entrez]
PHST- 2020/01/06 00:00 [pmc-release]
AID - PBIOLOGY-D-19-02507 [pii]
AID - 10.1371/journal.pbio.3000585 [doi]
PST - epublish
SO  - PLoS Biol. 2020 Jan 6;18(1):e3000585. doi: 10.1371/journal.pbio.3000585. 
      eCollection 2020 Jan.