PMID- 31905621
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Dec 28
TI  - The Clinical Outcomes Based on the Achievement of Low-Density Lipoprotein 
      Cholesterol Targets after ST Elevation Myocardial Infarction.
LID - 10.3390/jcm9010079 [doi]
LID - 79
AB  - The clinical outcome of patients with ST elevation myocardial infarction (STEMI) 
      undergoing primary percutaneous coronary intervention (PCI), with or without 
      achievement of low-density lipoprotein cholesterol (LDL-C) targets, has rarely 
      been investigated. This study was performed to investigate the comparison of 
      clinical outcome in STEMI patients with or without achievement LDL-C targets 
      (below 70 mg/dL and/or >/=50% reduction). Between November 2013 and December 2016, 
      689 STEMI patients underwent primary PCI in our hospital. Patients who were 
      deceased, lost to follow-up, had no follow-up lipid profile, or had no side 
      effects after statin use were excluded. A total of 343 patients were classified 
      into group 1 (with LDL-C target achievement) and 172 patients were classified 
      into group 2 (without LDL-C target achievement). Between the two groups, a higher 
      prevalence of left main coronary artery disease, smaller pre-PCI stenosis, and a 
      larger pre-PCI minimal luminal diameter were noted in group 2. The incidence of 
      post-MI angina (8.7% vs. 6.4%; p = 0.393), target vessel revascularization (2.3% 
      vs. 3.5%; p = 0.566), and recurrent MI (1.5% vs. 1.2%; p = 1.000), showed similar 
      results between the two groups during a one-year follow-up period. Initial LDL-C 
      levels >/=130 mg/dL, left main coronary artery disease, and absence of diabetes 
      mellitus were positively associated with non-achievement of LDL-C targets. After 
      STEMI, 66.6% of patients could achieve LDL-C targets one year later. However, 
      such patients did not show better clinical outcomes. Non-DM, initial LDL-C levels 
      >/=130 mg/dL, and left main coronary artery disease were related to non-achievement 
      of LDL-C targets.
FAU - Lee, Wei-Chieh
AU  - Lee WC
AUID- ORCID: 0000-0003-0585-6134
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, 
      Taiwan.
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan 701, Taiwan.
FAU - Fang, Chih-Yuan
AU  - Fang CY
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, 
      Taiwan.
FAU - Chen, Chien-Jen
AU  - Chen CJ
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, 
      Taiwan.
FAU - Yang, Cheng-Hsu
AU  - Yang CH
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, 
      Taiwan.
FAU - Wu, Chiung-Jen
AU  - Wu CJ
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, 
      Taiwan.
FAU - Fang, Hsiu-Yu
AU  - Fang HY
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20191228
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7020017
OTO - NOTNLM
OT  - ST elevation myocardial infarction
OT  - clinical outcomes
OT  - left main coronary artery disease
OT  - low-density lipoprotein cholesterol
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/08 06:00
MHDA- 2020/01/08 06:01
PMCR- 2019/12/28
CRDT- 2020/01/08 06:00
PHST- 2019/11/27 00:00 [received]
PHST- 2019/12/23 00:00 [revised]
PHST- 2019/12/25 00:00 [accepted]
PHST- 2020/01/08 06:00 [entrez]
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2020/01/08 06:01 [medline]
PHST- 2019/12/28 00:00 [pmc-release]
AID - jcm9010079 [pii]
AID - jcm-09-00079 [pii]
AID - 10.3390/jcm9010079 [doi]
PST - epublish
SO  - J Clin Med. 2019 Dec 28;9(1):79. doi: 10.3390/jcm9010079.