PMID- 31905811
OWN - NLM
STAT- MEDLINE
DCOM- 20200422
LR  - 20200422
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 1
DP  - 2019 Dec 30
TI  - Increased Risk of Site-Specific Cancer in People with Type 2 Diabetes: A National 
      Cohort Study.
LID - 10.3390/ijerph17010246 [doi]
LID - 246
AB  - A retrospective cohort design was used with the objective to evaluate cancer risk 
      among people with type 2 diabetes mellitus (T2DM) in Lithuania. The cohort was 
      established by identifying all patients with the first diagnosis of T2DM in the 
      National Health Insurance Fund database during 2000-2012. Cancer cases were 
      identified by record linkage with the Lithuanian Cancer Registry. Standardized 
      incidence ratios (SIRs) were calculated. Of the 127,290 people that were 
      included, 5959 cases of cancer in men and 6661 cancer cases in women with T2DM 
      were observed. A statistically significant increase in risk for all cancer sites 
      was observed in women, SIR 1.16 (95% CI 1.14-1.19), but not in men, SIR 1.00 (95% 
      CI 0.98-1.03). Among males, a significant increase of liver (SIR 2.11, 95% CI 
      1.79-2.49]), pancreas (SIR 1.77, 95% CI 1.57-1.99), kidney (SIR 1.46 95% CI 
      1.31-1.62), thyroid (SIR 1.83, 95% CI 1.32-2.54), colorectal (SIR 1.23, 95% CI 
      1.14-1.31]), skin melanoma (SIR 1.40, 95% CI 1.11-1.76), and non-melanoma skin 
      (SIR 1.14, 95% CI 1.05-1.23) cancer was observed. For females with T2DM, a 
      significant increase in risk of cancer of the liver (SIR 1.45, 95% CI 1.17-1.79), 
      pancreas (SIR 1.74, 95% CI 1.56-1.93), kidney (SIR = 1.43, 95% CI 1.28-1.60), 
      thyroid (SIR = 1.40, 95% CI 1.22-1.62), breast (SIR = 1.24, 95% CI 1.17-1.31), 
      and corpus uteri (SIR 2.07, 95% CI 1.93-2.21) was observed. In conclusion, people 
      with T2DM in Lithuania had an increased risk of site-specific cancer.
FAU - Linkeviciute-Ulinskiene, Donata
AU  - Linkeviciute-Ulinskiene D
AD  - Institute of Biomedical Sciences, Department of Pathology, Forensic Medicine and 
      Pharmacology, Faculty of Medicine, Vilnius University, Ciurlionio g. 21, 03101 
      Vilnius, Lithuania.
FAU - Patasius, Ausvydas
AU  - Patasius A
AUID- ORCID: 0000-0003-3874-2723
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio g. 3b, 
      08406 Vilnius, Lithuania.
AD  - Institute of Health Sciences, Faculty of Medicine, Vilnius University, Ciurlionio 
      g. 21, 03101 Vilnius, Lithuania.
FAU - Zabuliene, Lina
AU  - Zabuliene L
AUID- ORCID: 0000-0002-7889-0862
AD  - Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 
      Santariskiu g. 2, 08406 Vilnius, Lithuania.
FAU - Stukas, Rimantas
AU  - Stukas R
AD  - Institute of Health Sciences, Faculty of Medicine, Vilnius University, Ciurlionio 
      g. 21, 03101 Vilnius, Lithuania.
FAU - Smailyte, Giedre
AU  - Smailyte G
AUID- ORCID: 0000-0001-8365-543X
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio g. 3b, 
      08406 Vilnius, Lithuania.
AD  - Institute of Health Sciences, Faculty of Medicine, Vilnius University, Ciurlionio 
      g. 21, 03101 Vilnius, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20191230
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lithuania/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/classification/*epidemiology/etiology
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC6982113
OTO - NOTNLM
OT  - cancer
OT  - cohort
OT  - diabetes
OT  - population study
OT  - risk
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/08 06:00
MHDA- 2020/04/23 06:00
PMCR- 2020/01/01
CRDT- 2020/01/08 06:00
PHST- 2019/11/23 00:00 [received]
PHST- 2019/12/26 00:00 [revised]
PHST- 2019/12/28 00:00 [accepted]
PHST- 2020/01/08 06:00 [entrez]
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2020/04/23 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ijerph17010246 [pii]
AID - ijerph-17-00246 [pii]
AID - 10.3390/ijerph17010246 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2019 Dec 30;17(1):246. doi: 
      10.3390/ijerph17010246.