PMID- 31905985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Dec 30
TI  - Treatment with Tumor Necrosis Factor-alpha Inhibitors, History of Allergy, and 
      Hypercalcemia Are Risk Factors of Immune Reconstitution Inflammatory Syndrome in 
      HIV-Negative Pulmonary Tuberculosis Patients.
LID - 10.3390/jcm9010096 [doi]
LID - 96
AB  - Immune reconstitution inflammatory syndrome (IRIS) is an immune reaction that 
      occurs along with the recovery of the patient's immunity. Tuberculosis-related 
      IRIS (TB-IRIS) upon tumor necrosis factor (TNF)-alpha inhibitor treatment has been 
      reported in non-human immunodeficiency virus (HIV) patients. However, the 
      importance of biological treatment, as a risk factor of IRIS, has not yet been 
      established. In this study, we examined TB-IRIS in non-HIV patients to explore 
      the role of TNF-alpha inhibitor treatment. Out of 188 patients with pulmonary TB, 
      seven patients had IRIS. We examined univariate logistic and multivariate 
      analysis to elucidate risk factors of TB-IRIS. Univariate analysis indicated that 
      usage of immunosuppressive drugs, TNF-alpha inhibitors, and history of food or drug 
      allergy were significantly related with TB-IRIS. On initial treatment, the values 
      of serological markers such as serum albumin and serum calcium were significantly 
      related with TB-IRIS. There was a higher mortality rate in patients with TB-IRIS. 
      Furthermore, multivariate analysis revealed that usage of TNF-alpha inhibitors, 
      history of allergy, and serum hypercalcemia were related to TB-IRIS. Usage of 
      TNF-alpha inhibitors, history of allergy, and serum hypercalcemia may be independent 
      predictors of TB-IRIS in non-HIV patients. Since higher mortality has been 
      reported for TB-IRIS, we should pay attention to TB patients with these risk 
      factors.
FAU - Hachisu, Yoshimasa
AU  - Hachisu Y
AD  - Department of Allergy and Respiratory Medicine, Gunma University Graduate School 
      of Medicine, Gunma 371-8511, Japan.
AD  - Maebashi Red Cross Hospital, Gunma 371-0813, Japan.
FAU - Koga, Yasuhiko
AU  - Koga Y
AD  - Department of Allergy and Respiratory Medicine, Gunma University Graduate School 
      of Medicine, Gunma 371-8511, Japan.
FAU - Kasama, Shu
AU  - Kasama S
AD  - Institute for Clinical and Translational Science, Nara Medical University 
      Hospital, Nara 634-8522, Japan.
FAU - Kaira, Kyoichi
AU  - Kaira K
AD  - Department of Respiratory Medicine, Comprehensive Cancer Center, International 
      Medical Center, Saitama Medical University, Saitama 350-1298, Japan.
FAU - Yatomi, Masakiyo
AU  - Yatomi M
AD  - Department of Allergy and Respiratory Medicine, Gunma University Graduate School 
      of Medicine, Gunma 371-8511, Japan.
FAU - Aoki-Saito, Haruka
AU  - Aoki-Saito H
AD  - Department of Allergy and Respiratory Medicine, Gunma University Graduate School 
      of Medicine, Gunma 371-8511, Japan.
FAU - Tsurumaki, Hiroaki
AU  - Tsurumaki H
AD  - Department of Allergy and Respiratory Medicine, Gunma University Graduate School 
      of Medicine, Gunma 371-8511, Japan.
FAU - Kamide, Yosuke
AU  - Kamide Y
AD  - Clinical Research Center for Allergy and Rheumatology. Sagamihara National 
      Hospital, Kanagawa 252-0392, Japan.
FAU - Sunaga, Noriaki
AU  - Sunaga N
AD  - Department of Allergy and Respiratory Medicine, Gunma University Graduate School 
      of Medicine, Gunma 371-8511, Japan.
FAU - Maeno, Toshitaka
AU  - Maeno T
AD  - Department of Allergy and Respiratory Medicine, Gunma University Graduate School 
      of Medicine, Gunma 371-8511, Japan.
FAU - Ishizuka, Tamotsu
AU  - Ishizuka T
AD  - Third Department of Internal Medicine, Faculty of Medical Sciences, University of 
      Fukui, Fukui 910-1193, Japan.
FAU - Hisada, Takeshi
AU  - Hisada T
AD  - Gunma University Graduate School of Health Sciences, Gunma 371-8514, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191230
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7019635
OTO - NOTNLM
OT  - IRIS
OT  - TNF-alpha inhibitor
OT  - TNFI
OT  - Th1
OT  - Th2
OT  - history of allergy
OT  - hypercalcemia
OT  - immune reconstitution inflammatory syndrome
OT  - paradoxical response
OT  - tuberculosis
COIS- None declared.
EDAT- 2020/01/08 06:00
MHDA- 2020/01/08 06:01
PMCR- 2019/12/30
CRDT- 2020/01/08 06:00
PHST- 2019/11/28 00:00 [received]
PHST- 2019/12/27 00:00 [accepted]
PHST- 2020/01/08 06:00 [entrez]
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2020/01/08 06:01 [medline]
PHST- 2019/12/30 00:00 [pmc-release]
AID - jcm9010096 [pii]
AID - jcm-09-00096 [pii]
AID - 10.3390/jcm9010096 [doi]
PST - epublish
SO  - J Clin Med. 2019 Dec 30;9(1):96. doi: 10.3390/jcm9010096.