PMID- 31906264
OWN - NLM
STAT- MEDLINE
DCOM- 20201022
LR  - 20240328
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Jan 1
TI  - Energy Restriction and Colorectal Cancer: A Call for Additional Research.
LID - 10.3390/nu12010114 [doi]
LID - 114
AB  - : Colorectal cancer has the second highest cancer-related mortality rate, with an 
      estimated 881,000 deaths worldwide in 2018. The urgent need to reduce the 
      incidence and mortality rate requires innovative strategies to improve 
      prevention, early diagnosis, prognostic biomarkers, and treatment effectiveness. 
      Caloric restriction (CR) is known as the most robust nutritional intervention 
      that extends lifespan and delays the progression of age-related diseases, with 
      remarkable results for cancer protection. Other forms of energy restriction, such 
      as periodic fasting, intermittent fasting, or fasting-mimicking diets, with or 
      without reduction of total calorie intake, recapitulate the effects of chronic CR 
      and confer a wide range of beneficial effects towards health and survival, 
      including anti-cancer properties. In this review, the known molecular, cellular, 
      and organismal effects of energy restriction in oncology will be discussed. 
      Energy-restriction-based strategies implemented in colorectal models and clinical 
      trials will be also revised. While energy restriction constitutes a promising 
      intervention for the prevention and treatment of several malignant neoplasms, 
      further investigations are essential to dissect the interplay between fundamental 
      aspects of energy intake, such as feeding patterns, fasting length, or diet 
      composition, with all of them influencing health and disease or cancer effects. 
      Currently, effectiveness, safety, and practicability of different forms of 
      fasting to fight cancer, particularly colorectal cancer, should still be 
      contemplated with caution.
FAU - Castejon, Maria
AU  - Castejon M
AD  - Nutritional Interventions Group, Precision Nutrition and Aging Program, Institute 
      IMDEA Food (CEI UAM+CSIC), Crta. de Canto Blanco n masculine 8, E-28049 Madrid, Spain.
FAU - Plaza, Adrian
AU  - Plaza A
AD  - Bioactive Products and Metabolic Syndrome Group-BIOPROMET, Precision Nutrition 
      and Aging Program, Institute IMDEA Food (CEI UAM+CSIC), Crta. de Canto Blanco n masculine 
      8, E-28049 Madrid, Spain.
FAU - Martinez-Romero, Jorge
AU  - Martinez-Romero J
AD  - Molecular Oncology and Nutritional Genomics of Cancer Group, Precision Nutrition 
      and Cancer Program, Institute IMDEA Food (CEI, UAM/CSIC), Crta. de Canto Blanco 
      n masculine 8, E-28049 Madrid, Spain.
FAU - Fernandez-Marcos, Pablo Jose
AU  - Fernandez-Marcos PJ
AD  - Bioactive Products and Metabolic Syndrome Group-BIOPROMET, Precision Nutrition 
      and Aging Program, Institute IMDEA Food (CEI UAM+CSIC), Crta. de Canto Blanco n masculine 
      8, E-28049 Madrid, Spain.
FAU - Cabo, Rafael de
AU  - Cabo R
AD  - Nutritional Interventions Group, Precision Nutrition and Aging Program, Institute 
      IMDEA Food (CEI UAM+CSIC), Crta. de Canto Blanco n masculine 8, E-28049 Madrid, Spain.
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
FAU - Diaz-Ruiz, Alberto
AU  - Diaz-Ruiz A
AD  - Nutritional Interventions Group, Precision Nutrition and Aging Program, Institute 
      IMDEA Food (CEI UAM+CSIC), Crta. de Canto Blanco n masculine 8, E-28049 Madrid, Spain.
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
LA  - eng
GR  - Talento Grant 2018-T1/BMD-11966/Comunidad de Madrid/
GR  - Intramural Research Program/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20200101
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Caloric Restriction/*methods
MH  - Colorectal Neoplasms/mortality/*prevention & control
MH  - Diet/*methods
MH  - Energy Intake
MH  - Fasting
MH  - Humans
PMC - PMC7019819
OTO - NOTNLM
OT  - colorectal cancer models
OT  - energy restriction
OT  - metabolism
COIS- The authors declare no conflicts of interests.
EDAT- 2020/01/08 06:00
MHDA- 2020/10/23 06:00
PMCR- 2020/01/01
CRDT- 2020/01/08 06:00
PHST- 2019/12/07 00:00 [received]
PHST- 2019/12/26 00:00 [revised]
PHST- 2019/12/27 00:00 [accepted]
PHST- 2020/01/08 06:00 [entrez]
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2020/10/23 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - nu12010114 [pii]
AID - nutrients-12-00114 [pii]
AID - 10.3390/nu12010114 [doi]
PST - epublish
SO  - Nutrients. 2020 Jan 1;12(1):114. doi: 10.3390/nu12010114.