PMID- 31906278
OWN - NLM
STAT- MEDLINE
DCOM- 20201022
LR  - 20201022
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Jan 1
TI  - Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies.
LID - 10.3390/nu12010118 [doi]
LID - 118
AB  - Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by 
      insulin resistance and hyperglycemia. Current preventative and treatment 
      strategies for T2DM and insulin resistance lack in efficacy resulting in the need 
      for new approaches to prevent and manage/treat the disease better. In recent 
      years, epidemiological studies have suggested that diets rich in fruits and 
      vegetables have beneficial health effects including protection against insulin 
      resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids 
      have been reported to have antioxidant, anti-inflammatory, hepatoprotective, 
      nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. 
      The current review (I of II) summarizes the existing in vitro studies examining 
      the antidiabetic effects of curcumin, while a second (II of II) review summarizes 
      evidence from existing in vivo animal studies and clinical trials focusing on 
      curcumin's antidiabetic properties.
FAU - Den Hartogh, Danja J
AU  - Den Hartogh DJ
AD  - Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
AD  - Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
FAU - Gabriel, Alessandra
AU  - Gabriel A
AD  - Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
FAU - Tsiani, Evangelia
AU  - Tsiani E
AD  - Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
AD  - Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200101
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Hypoglycemic Agents)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Curcuma/*chemistry
MH  - Curcumin/*pharmacology
MH  - Diabetes Mellitus, Type 2/drug therapy
MH  - Humans
MH  - Hyperglycemia/drug therapy
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin Resistance
PMC - PMC7019345
OTO - NOTNLM
OT  - adipose
OT  - curcumin
OT  - curcuminoids
OT  - diabetes
OT  - insulin resistance
OT  - liver
OT  - pancreas
OT  - skeletal muscle
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/08 06:00
MHDA- 2020/10/23 06:00
PMCR- 2020/01/01
CRDT- 2020/01/08 06:00
PHST- 2019/11/15 00:00 [received]
PHST- 2019/12/24 00:00 [revised]
PHST- 2019/12/27 00:00 [accepted]
PHST- 2020/01/08 06:00 [entrez]
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2020/10/23 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - nu12010118 [pii]
AID - nutrients-12-00118 [pii]
AID - 10.3390/nu12010118 [doi]
PST - epublish
SO  - Nutrients. 2020 Jan 1;12(1):118. doi: 10.3390/nu12010118.