PMID- 31908645
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231113
IS  - 1658-3612 (Electronic)
IS  - 1658-3612 (Linking)
VI  - 14
IP  - 6
DP  - 2019 Dec
TI  - Periodontitis is associated with disease severity and anti-double stranded DNA 
      antibody and interferon-gamma levels in patients with systemic lupus 
      erythematosus.
PG  - 560-565
LID - 10.1016/j.jtumed.2019.09.005 [doi]
AB  - OBJECTIVES: To analyse the correlation between periodontitis severity and disease 
      activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma 
      (IFN-gamma) levels in patients with systemic lupus erythematous (SLE). METHODS: We 
      selected 61 patients with SLE (age 18-55 years) selected from a hospital in 
      Malang, Indonesia. Clinical examination and laboratory tests were performed to 
      assess disease activity. The severity of SLE was measured using the Systemic 
      Lupus Erythematosus Disease Activity Index (SLEDAI), while periodontitis severity 
      was measured according to the Periodontal Index (PI) criteria. Levels of 
      anti-dsDNA and IFN-gamma were determined using an enzyme-linked immunosorbent assay. 
      Optical density at 450 nm was measured using an automated plate reader. RESULTS: 
      The mean age of the subjects with SLE was 29 years, and mean disease duration was 
      2.8 years. Fifty-four of 61 (88.53%) subjects with SLE had periodontitis 
      according to the PI. SLE subjects exhibited other clinical manifestations such as 
      lupus nephritis, vasculitis, arthritis, mucocutaneous manifestation, fatigue, 
      fever, and/or leukopenia. SLE severity was assessed according to the average 
      SLEDAI score (17.70 +/- 12.70), and average anti-dsDNA (122.6 +/- 81.01 U/mL), and 
      IFN-gamma (14.64 +/- 11.17 pg/mL) levels. There was a significantly positive 
      correlation between periodontitis score and SLEDAI score (r = 0.927; p </= 0.0001), 
      anti-dsDNA antibody (r = 0.948; p </= 0.0001), and IFN-gamma (r = 0.951; p </= 0.0001) 
      levels. CONCLUSION: Results of the present study demonstrated that periodontitis 
      was associated with SLE disease activity, and was a biomarker of immune aging. 
      Furthermore, this biomarker could be a reliable predictor of periodontal 
      condition and prognosis of periodontitis and can also help in selecting the most 
      appropriate treatment strategy for periodontitis in patients with SLE.
CI  - (c) 2019 The Authors.
FAU - Gofur, Nanda R P
AU  - Gofur NRP
AD  - Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, 
      Malang, Indonesia.
FAU - Nurdiana, Nurdiana
AU  - Nurdiana N
AD  - Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, 
      Indonesia.
FAU - Kalim, Handono
AU  - Kalim H
AD  - Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, 
      Malang, Indonesia.
FAU - Handono, Kusworini
AU  - Handono K
AD  - Department of Pathology Clinic, Faculty of Medicine, Universitas Brawijaya, 
      Malang, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20191021
PL  - Saudi Arabia
TA  - J Taibah Univ Med Sci
JT  - Journal of Taibah University Medical Sciences
JID - 101621911
PMC - PMC6940663
OTO - NOTNLM
OT  - Anti-dsDNA antibody
OT  - ELISA
OT  - IFN-gamma
OT  - Periodontitis
OT  - SLE
EDAT- 2020/01/08 06:00
MHDA- 2020/01/08 06:01
PMCR- 2019/10/21
CRDT- 2020/01/08 06:00
PHST- 2019/06/27 00:00 [received]
PHST- 2019/09/05 00:00 [revised]
PHST- 2019/09/09 00:00 [accepted]
PHST- 2020/01/08 06:00 [entrez]
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2020/01/08 06:01 [medline]
PHST- 2019/10/21 00:00 [pmc-release]
AID - S1658-3612(19)30108-8 [pii]
AID - 10.1016/j.jtumed.2019.09.005 [doi]
PST - epublish
SO  - J Taibah Univ Med Sci. 2019 Oct 21;14(6):560-565. doi: 
      10.1016/j.jtumed.2019.09.005. eCollection 2019 Dec.