PMID- 31909831
OWN - NLM
STAT- MEDLINE
DCOM- 20200727
LR  - 20210402
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 159
IP  - 4
DP  - 2020 Apr
TI  - CD8alpha(-) conventional dendritic cells control Vbeta T-cell immunity in response to 
      Staphylococcus aureus infection in mice.
PG  - 404-412
LID - 10.1111/imm.13171 [doi]
AB  - Dendritic cells (DCs) are potent immune cells that control innate and adaptive 
      immune responses. Previous studies have shown that the DCs are required for 
      protection against Staphylococcus aureus infection. However, the role of 
      conventional DC (cDC) subsets during S. aureus infection in vivo has not been 
      well investigated. In this study, we examined the function of spleen DC subsets 
      in the activation of immunity against S. aureus infection. C57BL/6 mice were 
      infected intravenously with S. aureus and DC and T-cell activation were analyzed 
      in vivo. We found that the spleen CD8alpha(-) cDCs phagocytosed S. aureus more 
      efficiently than type-1 conventional DCs (cDC1s) did. Moreover, the CD8alpha(-) cDCs 
      contributed to the production of pro-inflammatory cytokines in response to 
      S. aureus infection, whereas the cDC1s did not. In addition, infection with 
      S. aureus promoted an increase in the number of Vbeta T cells. The CD4(+) and CD8(+) 
      Vbeta T cells up-regulated the production of interferon-gamma (IFN-gamma) and interleukin-17 
      (IL-17) in response to S. aureus infection. Importantly, the induction of IFN-gamma 
      and IL-17 production in CD4(+) and CD8(+) Vbeta T cells was mediated by 
      S. aureus-stimulated CD8alpha(-) cDCs, whereas cDC1s failed to promote IFN-gamma and 
      IL-17 production in the cells. Therefore, these data suggested that the spleen 
      CD8alpha(-) cDCs are the main DC subsets for induction of S. aureus 
      superantigen-specific immunity.
CI  - (c) 2020 John Wiley & Sons Ltd.
FAU - Zhang, Wei
AU  - Zhang W
AUID- ORCID: 0000-0002-9262-849X
AD  - Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, 
      Fudan University, Shanghai, China.
FAU - Xu, Li
AU  - Xu L
AUID- ORCID: 0000-0002-7883-0448
AD  - Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, 
      Fudan University, Shanghai, China.
FAU - Zhang, Xiaoyan
AU  - Zhang X
AUID- ORCID: 0000-0002-3193-1401
AD  - Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, 
      Fudan University, Shanghai, China.
FAU - Xu, Jianqing
AU  - Xu J
AUID- ORCID: 0000-0003-0896-9273
AD  - Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, 
      Fudan University, Shanghai, China.
FAU - Jin, Jun-O
AU  - Jin JO
AUID- ORCID: 0000-0003-4216-8111
AD  - Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, 
      Fudan University, Shanghai, China.
AD  - Department of Medical Biotechnology, Yeungnam University, Gyeongsan, South Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200121
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8 antigen, alpha chain)
RN  - 0 (Il17a protein, mouse)
RN  - 0 (Interleukin-17)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology/microbiology/pathology
MH  - CD8 Antigens/deficiency/genetics/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology/microbiology/pathology
MH  - Cell Lineage/immunology
MH  - Dendritic Cells/*immunology/microbiology
MH  - Gene Expression
MH  - Host-Pathogen Interactions/immunology
MH  - Immunity, Cellular
MH  - Interferon-gamma/genetics/immunology
MH  - Interleukin-17/genetics/immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phagocytosis
MH  - Receptors, Antigen, T-Cell, alpha-beta/genetics/*immunology
MH  - Spleen/immunology/microbiology/pathology
MH  - Staphylococcal Infections/*immunology/microbiology/pathology
MH  - Staphylococcus aureus/*immunology/pathogenicity
PMC - PMC7077999
OTO - NOTNLM
OT  - Staphylococcus aureus
OT  - CD8alpha- dendritic cells
OT  - Vbeta T cells
OT  - interferon-gamma
OT  - interleukin-17
COIS- Not applicable.
EDAT- 2020/01/08 06:00
MHDA- 2020/07/28 06:00
PMCR- 2021/04/01
CRDT- 2020/01/08 06:00
PHST- 2019/07/26 00:00 [received]
PHST- 2020/01/04 00:00 [revised]
PHST- 2020/01/06 00:00 [accepted]
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2020/07/28 06:00 [medline]
PHST- 2020/01/08 06:00 [entrez]
PHST- 2021/04/01 00:00 [pmc-release]
AID - IMM13171 [pii]
AID - 10.1111/imm.13171 [doi]
PST - ppublish
SO  - Immunology. 2020 Apr;159(4):404-412. doi: 10.1111/imm.13171. Epub 2020 Jan 21.