PMID- 31909909 OWN - NLM STAT- MEDLINE DCOM- 20210922 LR - 20210922 IS - 2386-5857 (Electronic) IS - 1137-6821 (Linking) VI - 32 IP - 1 DP - 2020 Feb TI - Amphetamine and methamphetamine poisonings attended in hospital emergency departments: clinical features and the usefulness of laboratory confirmation. PG - 26-32 AB - OBJECTIVES: To determine whether clinical and toxicologic findings differed between cases of amphetamine (AMP) and methamphetamine (mAMP) poisoning attended in 2 Balearic Island hospital emergency departments. MATERIAL AND METHODS: Retrospective observational study of AMP and mAMP cases with laboratory confirmation between 2013 and 2018. We compared clinical and toxicologic variables as well as clinical management between groups. RESULTS: 1) A total of 120 cases were found: 86 (71.7%) with AMP poisoning and 34 (28.3%) with mAMP poisoning. 2) Drug poisoning was confirmed by gas chromatography associated with mass spectrometry (GC-MS) in 787 urine samples found to be positive during screening. One hundred fifty-four (19.6%) were confirmed by GC-MS. Thirtyfour of them did not meet the inclusion criteria. 3) Significant differences between AMP and mAMP cases were found for age (32.3 vs 28.4 y, respectively); sex (72.1% vs 94.1% men); and Spanish nationality (64.0% vs 29.4%). Reasons for admission and clinical features also differed: the reasons were aberrant behavior (15.1% in the AMP group vs 0% in the mAMP group) and palpitations (1.2% vs 20.6%); agitation was observed in 27.9% and 8.8%, respectively. Clinical management was similar in the 2 groups. Multiple drug poisoning was detected in 76.6% patients and was more common in patients in the AMP group (82.6% vs 61.8%). The additional drugs in these cases were mainly cocaine (63.0%), cannabis (48.9%), 3,4-methylenedioxy-N-methamphetamine (MDMA) (38.0%), and alcohol (35.9%). Cannabis was detected in a significantly higher proportion in the AMP group (45.3%) than in the mAMP group (17.6%). False positives were found in 78.7% of the samples. The culprit drug was most often MDMA (71.2%). CONCLUSION: AMP poisonings were associated with age over 30 years, Spanish nationality, aberrant behavior, agitation, multiple drug findings, and the use of cannabis. Poisonings caused by mAMP abuse were associated with age under 30 years, non-Spanish nationality, palpitations, and single-drug use. FAU - Roset Ferrer, Carolina AU - Roset Ferrer C AD - Servicio de Psiquiatria, Hospital Universitari Son Espases, Palma de Mallorca, Espana. FAU - Gomila Muniz, Isabel AU - Gomila Muniz I AD - Servicio de Analisis Clinicos, Hospital Universitari Son Llatzer, Palma de Mallorca, Espana. Instituto de Investigacion Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Espana. FAU - Elorza Guerrero, Miguel Angel AU - Elorza Guerrero MA AD - Instituto de Investigacion Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Espana. Servicio de Analisis Clinicos, Unidad de Toxicologia Clinica, Hospital Universitari Son Espases, Palma de Mallorca, Espana. FAU - Puiguriguer Ferrando, Jordi AU - Puiguriguer Ferrando J AD - Instituto de Investigacion Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Espana. Servicio de Urgencias, Unidad de Toxicologia Clinica, Hospital Universitari Son Espases, Palma de Mallorca, Espana. FAU - Lecinena Estean, Maria Angeles AU - Lecinena Estean MA AD - Servicio de Urgencias, Hospital Can Misses, Ibiza, Espana. FAU - Tuero Leon, Gaspar AU - Tuero Leon G AD - Servicio de Medicina Intensiva, Hospital Can Misses, Ibiza, Espana. FAU - Sahuquillo Frias, Laura AU - Sahuquillo Frias L AD - Servicio de Analisis Clinicos, Hospital Can Misses, Ibiza, Espana. FAU - Ripoll Vera, Tomas AU - Ripoll Vera T AD - Instituto de Investigacion Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Espana. Servicio de Cardiologia, Hospital Universitari Son Llatzer, Palma de Mallorca, Espana. FAU - Socias Crespi, Lorenzo AU - Socias Crespi L AD - Instituto de Investigacion Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Espana. Servicio de Medicina Intensiva, Hospital Universitario Son Llatzer, Palma de Mallorca, Espana. FAU - Sanchis Cortes, Pilar AU - Sanchis Cortes P AD - Instituto de Investigacion Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Espana. Departamento de Quimica, Universidad de las Islas Baleares, Palma de Mallorca, Espana. FAU - Barcelo Martin, Bernardino AU - Barcelo Martin B AD - Instituto de Investigacion Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Espana. Servicio de Analisis Clinicos, Unidad de Toxicologia Clinica, Hospital Universitari Son Espases, Palma de Mallorca, Espana. LA - eng LA - spa PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't TT - Intoxicaciones por anfetamina y metanfetamina atendidas en los servicios de urgencias: caracteristicas clinicas y utilidad de la confirmacion analitica. PL - Spain TA - Emergencias JT - Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias JID - 9805751 RN - 44RAL3456C (Methamphetamine) RN - CK833KGX7E (Amphetamine) SB - IM CIN - Emergencias. 2020 Ago;32(4):303. PMID: 32692019 CIN - Emergencias. 2020 Ago;32(4):303-304. PMID: 32692020 MH - Adult MH - Amphetamine/*poisoning MH - *Amphetamine-Related Disorders/diagnosis/epidemiology MH - Emergency Service, Hospital MH - Female MH - Hospitals MH - Humans MH - Male MH - Methamphetamine/*poisoning MH - Spain MH - *Substance Abuse Detection OTO - NOTNLM OT - Anfetamina OT - Amphetamine OT - Confirmacion analitica OT - Emergency department OT - Intoxicaciones OT - Laboratory confirmation OT - Metanfetamina OT - Methamphetamine OT - Poisoning OT - Servicio de urgencias EDAT- 2020/01/08 06:00 MHDA- 2021/09/23 06:00 CRDT- 2020/01/08 06:00 PHST- 2020/01/08 06:00 [entrez] PHST- 2020/01/08 06:00 [pubmed] PHST- 2021/09/23 06:00 [medline] PST - ppublish SO - Emergencias. 2020 Feb;32(1):26-32.